Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes

The cancer-specific fusion oncoprotein SS18–SSX1 disturbs chromatin accessibility by hijacking the BAF complex from the promoters and enhancers to the Polycomb-repressed chromatin regions. This process relies on the selective recognition of H2AK119Ub nucleosomes by synovial sarcoma X breakpoint 1 (S...

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Veröffentlicht in:	Nature structural & molecular biology 2024-02, Vol.31 (2), p.300-310
Hauptverfasser:	Tong, Zebin, Ai, Huasong, Xu, Ziyu, He, Kezhang, Chu, Guo-Chao, Shi, Qiang, Deng, Zhiheng, Xue, Qiaomei, Sun, Maoshen, Du, Yunxiang, Liang, Lujun, Li, Jia-Bin, Pan, Man, Liu, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 45/22 45/23 45/29 45/77 631/337/100 631/337/100/2285 631/535/1258/1259 631/80/458/582 631/92/458/582 Binding Biochemistry Biological Microscopy Biomedical and Life Sciences Cancer Cell Membrane - metabolism Chromatin Grooves Humans Life Sciences Membrane Biology Nucleosomes Oncogene Proteins, Fusion - genetics Polycomb group proteins Protein Structure Recognition Sarcoma Sarcoma, Synovial - metabolism Ubiquitin
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