Cucurbit8uril Binds Nonterminal Dipeptide Sites with High Affinity and Induces a Type II β-Turn

In an effort to target polypeptides at nonterminal sites, we screened the binding of the synthetic receptor cucurbit[8]uril (Q8) to a small library of tetrapeptides, each containing a nonterminal dipeptide binding site. The resulting leads were characterized in detail using a combination of isotherm...

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Veröffentlicht in:	Journal of the American Chemical Society 2024-03, Vol.146 (11), p.7649
Hauptverfasser:	Suating, Paolo, Kimberly, Lauren B, Ewe, Marc B, Chang, Sarah L, Fontenot, John M, Sultane, Prakash R, Bielawski, Christopher W, Decato, Daniel A, Berryman, Orion B, Taylor, Alexander B, Urbach, Adam R
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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