Ion-Selective Micropipette Sensor for In Vivo Monitoring of Sodium Ion with Crown Ether-Encapsulated Metal–Organic Framework Subnanopores
In vivo sensing of the dynamics of ions with high selectivity is essential for gaining molecular insights into numerous physiological and pathological processes. In this work, we report an ion-selective micropipette sensor (ISMS) through the integration of functional crown ether-encapsulated metal–o...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2024-02, Vol.96 (6), p.2651-2657 |
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| creator | Liu, Jiahao Lu, Jiahao Ji, Wenliang Lu, Guangwen Wang, Jiao Ye, Tingyan Jiang, Yisha Zheng, Juanjuan Yu, Ping Liu, Nannan Jiang, Yanan Mao, Lanqun |
| description | In vivo sensing of the dynamics of ions with high selectivity is essential for gaining molecular insights into numerous physiological and pathological processes. In this work, we report an ion-selective micropipette sensor (ISMS) through the integration of functional crown ether-encapsulated metal–organic frameworks (MOFs) synthesized in situ within the micropipette tip. The ISMS features distinctive sodium ion (Na+) conduction and high selectivity toward Na+ sensing. The selectivity is attributed to the synergistic effects of subnanoconfined space and the specific coordination of 18-crown-6 toward potassium ions (K+), which largely increase the steric hindrance and transport resistance for K+ to pass through the ISMS. Furthermore, the ISMS exhibits high stability and sensitivity, facilitating real-time monitoring of Na+ dynamics in the living rat brain during spreading of the depression events process. In light of the diversity of crown ethers and MOFs, we believe this study paves the way for a nanofluidic platform for in vivo sensing and neuromorphic electrochemical sensing. |
| doi_str_mv | 10.1021/acs.analchem.3c05366 |
| format | Article |
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In this work, we report an ion-selective micropipette sensor (ISMS) through the integration of functional crown ether-encapsulated metal–organic frameworks (MOFs) synthesized in situ within the micropipette tip. The ISMS features distinctive sodium ion (Na+) conduction and high selectivity toward Na+ sensing. The selectivity is attributed to the synergistic effects of subnanoconfined space and the specific coordination of 18-crown-6 toward potassium ions (K+), which largely increase the steric hindrance and transport resistance for K+ to pass through the ISMS. Furthermore, the ISMS exhibits high stability and sensitivity, facilitating real-time monitoring of Na+ dynamics in the living rat brain during spreading of the depression events process. In light of the diversity of crown ethers and MOFs, we believe this study paves the way for a nanofluidic platform for in vivo sensing and neuromorphic electrochemical sensing.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/acs.analchem.3c05366</identifier><identifier>PMID: 38306178</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Crown ethers ; Dynamic stability ; Electrochemistry ; Encapsulation ; Ethers ; Fluidics ; In vivo methods and tests ; Ions ; Metal-organic frameworks ; Monitoring ; Nanofluids ; Potassium ; Selectivity ; Sodium ; Spreading depression ; Steric hindrance ; Synergistic effect</subject><ispartof>Analytical chemistry (Washington), 2024-02, Vol.96 (6), p.2651-2657</ispartof><rights>2024 American Chemical Society</rights><rights>Copyright American Chemical Society Feb 13, 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a376t-783ef970718f9c5cae06cd80ab3c1b2393fab8f08a9e8d80757e3b8a911929f53</citedby><cites>FETCH-LOGICAL-a376t-783ef970718f9c5cae06cd80ab3c1b2393fab8f08a9e8d80757e3b8a911929f53</cites><orcidid>0000-0002-4335-1383 ; 0000-0001-9235-2633 ; 0000-0002-6096-1933 ; 0000-0001-8286-9321</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.analchem.3c05366$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.analchem.3c05366$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38306178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Jiahao</creatorcontrib><creatorcontrib>Lu, Jiahao</creatorcontrib><creatorcontrib>Ji, Wenliang</creatorcontrib><creatorcontrib>Lu, Guangwen</creatorcontrib><creatorcontrib>Wang, Jiao</creatorcontrib><creatorcontrib>Ye, Tingyan</creatorcontrib><creatorcontrib>Jiang, Yisha</creatorcontrib><creatorcontrib>Zheng, Juanjuan</creatorcontrib><creatorcontrib>Yu, Ping</creatorcontrib><creatorcontrib>Liu, Nannan</creatorcontrib><creatorcontrib>Jiang, Yanan</creatorcontrib><creatorcontrib>Mao, Lanqun</creatorcontrib><title>Ion-Selective Micropipette Sensor for In Vivo Monitoring of Sodium Ion with Crown Ether-Encapsulated Metal–Organic Framework Subnanopores</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. 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In light of the diversity of crown ethers and MOFs, we believe this study paves the way for a nanofluidic platform for in vivo sensing and neuromorphic electrochemical sensing.</description><subject>Crown ethers</subject><subject>Dynamic stability</subject><subject>Electrochemistry</subject><subject>Encapsulation</subject><subject>Ethers</subject><subject>Fluidics</subject><subject>In vivo methods and tests</subject><subject>Ions</subject><subject>Metal-organic frameworks</subject><subject>Monitoring</subject><subject>Nanofluids</subject><subject>Potassium</subject><subject>Selectivity</subject><subject>Sodium</subject><subject>Spreading depression</subject><subject>Steric hindrance</subject><subject>Synergistic effect</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kcFuEzEURS0EoqHwBwhZYtPNhOdxx_YsUZRCpEZdBNiOPM6bxmXGHmxPI3bsWfKHfAkOSbtgwcKybJ17nvQuIa8ZzBmU7J02ca6d7s0Ohzk3UHEhnpAZq0oohFLlUzIDAF6UEuCMvIjxDoAxYOI5OeOKg2BSzcjPlXfFBns0yd4jXVsT_GhHTAnpBl30gXb5rBz9Yu89XXtnkw_W3VLf0Y3f2mmgWUH3Nu3oIvi9o8u0w1AsndFjnHqdcEvXmHT_-8evm3CrnTX0KugB9z58pZupddr50QeML8mzTvcRX53uc_L5avlp8bG4vvmwWry_LjSXIhVScexqCZKprjaV0QjCbBXolhvWlrzmnW5VB0rXqPK_rCTyNr8Yq8u6q_g5uTh6x-C_TRhTM9hosO-1Qz_FpqxLAVJwDhl9-w9656eQt_6Xkpcqkwfh5ZHKy4sxYNeMwQ46fG8YNIeymlxW81BWcyorx96c5FM74PYx9NBOBuAIHOKPg__r_AMdyqY6</recordid><startdate>20240213</startdate><enddate>20240213</enddate><creator>Liu, Jiahao</creator><creator>Lu, Jiahao</creator><creator>Ji, Wenliang</creator><creator>Lu, Guangwen</creator><creator>Wang, Jiao</creator><creator>Ye, Tingyan</creator><creator>Jiang, Yisha</creator><creator>Zheng, Juanjuan</creator><creator>Yu, Ping</creator><creator>Liu, Nannan</creator><creator>Jiang, Yanan</creator><creator>Mao, Lanqun</creator><general>American Chemical Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4335-1383</orcidid><orcidid>https://orcid.org/0000-0001-9235-2633</orcidid><orcidid>https://orcid.org/0000-0002-6096-1933</orcidid><orcidid>https://orcid.org/0000-0001-8286-9321</orcidid></search><sort><creationdate>20240213</creationdate><title>Ion-Selective Micropipette Sensor for In Vivo Monitoring of Sodium Ion with Crown Ether-Encapsulated Metal–Organic Framework Subnanopores</title><author>Liu, Jiahao ; Lu, Jiahao ; Ji, Wenliang ; Lu, Guangwen ; Wang, Jiao ; Ye, Tingyan ; Jiang, Yisha ; Zheng, Juanjuan ; Yu, Ping ; Liu, Nannan ; Jiang, Yanan ; Mao, Lanqun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a376t-783ef970718f9c5cae06cd80ab3c1b2393fab8f08a9e8d80757e3b8a911929f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Crown ethers</topic><topic>Dynamic stability</topic><topic>Electrochemistry</topic><topic>Encapsulation</topic><topic>Ethers</topic><topic>Fluidics</topic><topic>In vivo methods and tests</topic><topic>Ions</topic><topic>Metal-organic frameworks</topic><topic>Monitoring</topic><topic>Nanofluids</topic><topic>Potassium</topic><topic>Selectivity</topic><topic>Sodium</topic><topic>Spreading depression</topic><topic>Steric hindrance</topic><topic>Synergistic effect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Jiahao</creatorcontrib><creatorcontrib>Lu, Jiahao</creatorcontrib><creatorcontrib>Ji, Wenliang</creatorcontrib><creatorcontrib>Lu, Guangwen</creatorcontrib><creatorcontrib>Wang, Jiao</creatorcontrib><creatorcontrib>Ye, Tingyan</creatorcontrib><creatorcontrib>Jiang, Yisha</creatorcontrib><creatorcontrib>Zheng, Juanjuan</creatorcontrib><creatorcontrib>Yu, Ping</creatorcontrib><creatorcontrib>Liu, Nannan</creatorcontrib><creatorcontrib>Jiang, Yanan</creatorcontrib><creatorcontrib>Mao, Lanqun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Jiahao</au><au>Lu, Jiahao</au><au>Ji, Wenliang</au><au>Lu, Guangwen</au><au>Wang, Jiao</au><au>Ye, Tingyan</au><au>Jiang, Yisha</au><au>Zheng, Juanjuan</au><au>Yu, Ping</au><au>Liu, Nannan</au><au>Jiang, Yanan</au><au>Mao, Lanqun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ion-Selective Micropipette Sensor for In Vivo Monitoring of Sodium Ion with Crown Ether-Encapsulated Metal–Organic Framework Subnanopores</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2024-02-13</date><risdate>2024</risdate><volume>96</volume><issue>6</issue><spage>2651</spage><epage>2657</epage><pages>2651-2657</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><abstract>In vivo sensing of the dynamics of ions with high selectivity is essential for gaining molecular insights into numerous physiological and pathological processes. In this work, we report an ion-selective micropipette sensor (ISMS) through the integration of functional crown ether-encapsulated metal–organic frameworks (MOFs) synthesized in situ within the micropipette tip. The ISMS features distinctive sodium ion (Na+) conduction and high selectivity toward Na+ sensing. The selectivity is attributed to the synergistic effects of subnanoconfined space and the specific coordination of 18-crown-6 toward potassium ions (K+), which largely increase the steric hindrance and transport resistance for K+ to pass through the ISMS. Furthermore, the ISMS exhibits high stability and sensitivity, facilitating real-time monitoring of Na+ dynamics in the living rat brain during spreading of the depression events process. In light of the diversity of crown ethers and MOFs, we believe this study paves the way for a nanofluidic platform for in vivo sensing and neuromorphic electrochemical sensing.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>38306178</pmid><doi>10.1021/acs.analchem.3c05366</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4335-1383</orcidid><orcidid>https://orcid.org/0000-0001-9235-2633</orcidid><orcidid>https://orcid.org/0000-0002-6096-1933</orcidid><orcidid>https://orcid.org/0000-0001-8286-9321</orcidid></addata></record> |
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| ispartof | Analytical chemistry (Washington), 2024-02, Vol.96 (6), p.2651-2657 |
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| subjects | Crown ethers Dynamic stability Electrochemistry Encapsulation Ethers Fluidics In vivo methods and tests Ions Metal-organic frameworks Monitoring Nanofluids Potassium Selectivity Sodium Spreading depression Steric hindrance Synergistic effect |
| title | Ion-Selective Micropipette Sensor for In Vivo Monitoring of Sodium Ion with Crown Ether-Encapsulated Metal–Organic Framework Subnanopores |
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