Nrf2 prevents diabetic cardiomyopathy via antioxidant effect and normalization of glucose and lipid metabolism in the heart

Metabolic disorders and oxidative stress are the main causes of diabetic cardiomyopathy. Activation of nuclear factor erythroid 2‐related factor 2 (Nrf2) exerts a powerful antioxidant effect and prevents the progression of diabetic cardiomyopathy. However, the mechanism of its cardiac protection and...

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Veröffentlicht in:	Journal of cellular physiology 2024-02, Vol.239 (2), p.e31149-n/a
Hauptverfasser:	Yang, Ge, Zhang, Qihe, Dong, Chao, Hou, Guowen, Li, Jinjie, Jiang, Xin, Xin, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Antioxidants Cardiomyocytes Cardiomyopathy Diabetes Diabetes mellitus (insulin dependent) diabetic cardiomyopathy Echocardiography Fibrosis Glucose glucose metabolic disorder Glucose metabolism Heart lipid metabolic disorder Lipid metabolism Lipids LKB1 protein Metabolic disorders Metabolic pathways Metabolism Nrf2 Oxidative stress SIRT1 protein Streptozocin Transcription activation Transgenic animals Transgenic mice
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