Tumor-positive peritoneal cytology in patients with gastric cancer is associated with poor outcome: A nationwide study
The clinical significance of tumor-positive peritoneal cytology (CYT+) in gastric cancer (GC) patients is unclear. This nationwide cohort study aimed to i) assess the frequency of cytological analysis at staging laparoscopy; ii) determine the prevalence of CYT+GC; and iii) compare overall survival (...
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| Veröffentlicht in: | European journal of cancer (1990) 2024-03, Vol.199, p.113541, Article 113541 |
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| container_title | European journal of cancer (1990) |
| container_volume | 199 |
| creator | Van Der Sluis, Karen Taylor, Steven N. Kodach, Liudmila L. van Dieren, Jolanda M. de Hingh, Ignace H.J.T. Wijnhoven, Bas P.L. Verhoeven, Rob H.A. Vollebergh, Marieke A. van Sandick, Johanna W. |
| description | The clinical significance of tumor-positive peritoneal cytology (CYT+) in gastric cancer (GC) patients is unclear. This nationwide cohort study aimed to i) assess the frequency of cytological analysis at staging laparoscopy; ii) determine the prevalence of CYT+GC; and iii) compare overall survival (OS) in CYT+ patients versus those with (PM+) and those without (PM-) macroscopic peritoneal disease.
All patients diagnosed with cT1–4, cN0–2 and M0 or synchronous PM GC between 2016–2021 were identified in the Netherlands Cancer Registry database and linked to the nationwide pathology database.
A total of 4397 patients was included, of which 40 % underwent cytological assessment following staging laparoscopy (863/1745). The prevalence of CYT+ was 8 %. A total of 69 patients had CYT+(1.6 %), 789 (17.9 %) had PM+ and 3539 (80.5 %) had PM- disease. Hazard ratio for OS in CYT+ versus PM+ was 0.86 (95 %CI 0.64–1.17, p-value=0.338), and in PM- versus PM+0.43 (95 %CI 0.38–0.49, p-value |
| doi_str_mv | 10.1016/j.ejca.2024.113541 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2925486314</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0959804924000170</els_id><sourcerecordid>2925486314</sourcerecordid><originalsourceid>FETCH-LOGICAL-c307t-bfb75466a95f7c17dc7ae0b487c5a92149635bb1694f84bce49a8f22f1800eb53</originalsourceid><addsrcrecordid>eNp9kEFv1DAQRi1ERZfCH-CAfOSSxXbs2EZcqooCUiUu7dlyJpPiVRIH29lq_z1ZpeXIaS7ve9I8Qj5wtueMN58PezyA3wsm5J7zWkn-iuy40bZiRonXZMesspVh0l6StzkfGGPaSPaGXNZG1LrWfEeO98sYUzXHHEo4Ip0xhRIn9AOFU4lDfDzRMNHZl4BTyfQplN_00eeSAlDwE2CiIVOfc4TgC3YbMceYaFwKxBG_0Gs6rfs4PYUOaS5Ld3pHLno_ZHz_fK_Iw-23-5sf1d2v7z9vru8qqJkuVdu3Wsmm8Vb1GrjuQHtkrTQalLeCS9vUqm15Y2VvZAsorTe9ED03jGGr6ivyafPOKf5ZMBc3hgw4DH7CuGQnrFDSNDWXKyo2FFLMOWHv5hRGn06OM3fu7Q7u3Nude7ut9zr6-Oxf2hG7f5OXwCvwdQNw_fIYMLkMa0nALiSE4roY_uf_Cw57k1o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2925486314</pqid></control><display><type>article</type><title>Tumor-positive peritoneal cytology in patients with gastric cancer is associated with poor outcome: A nationwide study</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Van Der Sluis, Karen ; Taylor, Steven N. ; Kodach, Liudmila L. ; van Dieren, Jolanda M. ; de Hingh, Ignace H.J.T. ; Wijnhoven, Bas P.L. ; Verhoeven, Rob H.A. ; Vollebergh, Marieke A. ; van Sandick, Johanna W.</creator><creatorcontrib>Van Der Sluis, Karen ; Taylor, Steven N. ; Kodach, Liudmila L. ; van Dieren, Jolanda M. ; de Hingh, Ignace H.J.T. ; Wijnhoven, Bas P.L. ; Verhoeven, Rob H.A. ; Vollebergh, Marieke A. ; van Sandick, Johanna W.</creatorcontrib><description>The clinical significance of tumor-positive peritoneal cytology (CYT+) in gastric cancer (GC) patients is unclear. This nationwide cohort study aimed to i) assess the frequency of cytological analysis at staging laparoscopy; ii) determine the prevalence of CYT+GC; and iii) compare overall survival (OS) in CYT+ patients versus those with (PM+) and those without (PM-) macroscopic peritoneal disease.
All patients diagnosed with cT1–4, cN0–2 and M0 or synchronous PM GC between 2016–2021 were identified in the Netherlands Cancer Registry database and linked to the nationwide pathology database.
A total of 4397 patients was included, of which 40 % underwent cytological assessment following staging laparoscopy (863/1745). The prevalence of CYT+ was 8 %. A total of 69 patients had CYT+(1.6 %), 789 (17.9 %) had PM+ and 3539 (80.5 %) had PM- disease. Hazard ratio for OS in CYT+ versus PM+ was 0.86 (95 %CI 0.64–1.17, p-value=0.338), and in PM- versus PM+0.43 (95 %CI 0.38–0.49, p-value<0.001). No survival difference was found between systemic chemotherapy versus surgical resection in CYT+ patients.
In this nationwide study, OS for gastric cancer patients with CYT+ was equally unfavorable as for those with PM+ and significantly worse as compared to those with PM-. The optimal treatment strategy has yet to be established.
[Display omitted]
•Tumor-positive peritoneal cytology and PM in GC had a comparable dismal survival.•Surgery and systemic treatment in CYT+ patients showed equal survival figures.•Staging laparoscopy including cytology improves patient selection for GC therapy.</description><identifier>ISSN: 0959-8049</identifier><identifier>ISSN: 1879-0852</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/j.ejca.2024.113541</identifier><identifier>PMID: 38237371</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Cohort Studies ; Cytodiagnosis ; Cytology ; Gastric cancer ; Humans ; Lavage ; Neoplasm Staging ; Peritoneal Lavage ; Peritoneal metastases ; Prognosis ; Staging laparoscopy ; Stomach Neoplasms - pathology</subject><ispartof>European journal of cancer (1990), 2024-03, Vol.199, p.113541, Article 113541</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c307t-bfb75466a95f7c17dc7ae0b487c5a92149635bb1694f84bce49a8f22f1800eb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0959804924000170$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38237371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Der Sluis, Karen</creatorcontrib><creatorcontrib>Taylor, Steven N.</creatorcontrib><creatorcontrib>Kodach, Liudmila L.</creatorcontrib><creatorcontrib>van Dieren, Jolanda M.</creatorcontrib><creatorcontrib>de Hingh, Ignace H.J.T.</creatorcontrib><creatorcontrib>Wijnhoven, Bas P.L.</creatorcontrib><creatorcontrib>Verhoeven, Rob H.A.</creatorcontrib><creatorcontrib>Vollebergh, Marieke A.</creatorcontrib><creatorcontrib>van Sandick, Johanna W.</creatorcontrib><title>Tumor-positive peritoneal cytology in patients with gastric cancer is associated with poor outcome: A nationwide study</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>The clinical significance of tumor-positive peritoneal cytology (CYT+) in gastric cancer (GC) patients is unclear. This nationwide cohort study aimed to i) assess the frequency of cytological analysis at staging laparoscopy; ii) determine the prevalence of CYT+GC; and iii) compare overall survival (OS) in CYT+ patients versus those with (PM+) and those without (PM-) macroscopic peritoneal disease.
All patients diagnosed with cT1–4, cN0–2 and M0 or synchronous PM GC between 2016–2021 were identified in the Netherlands Cancer Registry database and linked to the nationwide pathology database.
A total of 4397 patients was included, of which 40 % underwent cytological assessment following staging laparoscopy (863/1745). The prevalence of CYT+ was 8 %. A total of 69 patients had CYT+(1.6 %), 789 (17.9 %) had PM+ and 3539 (80.5 %) had PM- disease. Hazard ratio for OS in CYT+ versus PM+ was 0.86 (95 %CI 0.64–1.17, p-value=0.338), and in PM- versus PM+0.43 (95 %CI 0.38–0.49, p-value<0.001). No survival difference was found between systemic chemotherapy versus surgical resection in CYT+ patients.
In this nationwide study, OS for gastric cancer patients with CYT+ was equally unfavorable as for those with PM+ and significantly worse as compared to those with PM-. The optimal treatment strategy has yet to be established.
[Display omitted]
•Tumor-positive peritoneal cytology and PM in GC had a comparable dismal survival.•Surgery and systemic treatment in CYT+ patients showed equal survival figures.•Staging laparoscopy including cytology improves patient selection for GC therapy.</description><subject>Cohort Studies</subject><subject>Cytodiagnosis</subject><subject>Cytology</subject><subject>Gastric cancer</subject><subject>Humans</subject><subject>Lavage</subject><subject>Neoplasm Staging</subject><subject>Peritoneal Lavage</subject><subject>Peritoneal metastases</subject><subject>Prognosis</subject><subject>Staging laparoscopy</subject><subject>Stomach Neoplasms - pathology</subject><issn>0959-8049</issn><issn>1879-0852</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFv1DAQRi1ERZfCH-CAfOSSxXbs2EZcqooCUiUu7dlyJpPiVRIH29lq_z1ZpeXIaS7ve9I8Qj5wtueMN58PezyA3wsm5J7zWkn-iuy40bZiRonXZMesspVh0l6StzkfGGPaSPaGXNZG1LrWfEeO98sYUzXHHEo4Ip0xhRIn9AOFU4lDfDzRMNHZl4BTyfQplN_00eeSAlDwE2CiIVOfc4TgC3YbMceYaFwKxBG_0Gs6rfs4PYUOaS5Ld3pHLno_ZHz_fK_Iw-23-5sf1d2v7z9vru8qqJkuVdu3Wsmm8Vb1GrjuQHtkrTQalLeCS9vUqm15Y2VvZAsorTe9ED03jGGr6ivyafPOKf5ZMBc3hgw4DH7CuGQnrFDSNDWXKyo2FFLMOWHv5hRGn06OM3fu7Q7u3Nude7ut9zr6-Oxf2hG7f5OXwCvwdQNw_fIYMLkMa0nALiSE4roY_uf_Cw57k1o</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Van Der Sluis, Karen</creator><creator>Taylor, Steven N.</creator><creator>Kodach, Liudmila L.</creator><creator>van Dieren, Jolanda M.</creator><creator>de Hingh, Ignace H.J.T.</creator><creator>Wijnhoven, Bas P.L.</creator><creator>Verhoeven, Rob H.A.</creator><creator>Vollebergh, Marieke A.</creator><creator>van Sandick, Johanna W.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202403</creationdate><title>Tumor-positive peritoneal cytology in patients with gastric cancer is associated with poor outcome: A nationwide study</title><author>Van Der Sluis, Karen ; Taylor, Steven N. ; Kodach, Liudmila L. ; van Dieren, Jolanda M. ; de Hingh, Ignace H.J.T. ; Wijnhoven, Bas P.L. ; Verhoeven, Rob H.A. ; Vollebergh, Marieke A. ; van Sandick, Johanna W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-bfb75466a95f7c17dc7ae0b487c5a92149635bb1694f84bce49a8f22f1800eb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cohort Studies</topic><topic>Cytodiagnosis</topic><topic>Cytology</topic><topic>Gastric cancer</topic><topic>Humans</topic><topic>Lavage</topic><topic>Neoplasm Staging</topic><topic>Peritoneal Lavage</topic><topic>Peritoneal metastases</topic><topic>Prognosis</topic><topic>Staging laparoscopy</topic><topic>Stomach Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Der Sluis, Karen</creatorcontrib><creatorcontrib>Taylor, Steven N.</creatorcontrib><creatorcontrib>Kodach, Liudmila L.</creatorcontrib><creatorcontrib>van Dieren, Jolanda M.</creatorcontrib><creatorcontrib>de Hingh, Ignace H.J.T.</creatorcontrib><creatorcontrib>Wijnhoven, Bas P.L.</creatorcontrib><creatorcontrib>Verhoeven, Rob H.A.</creatorcontrib><creatorcontrib>Vollebergh, Marieke A.</creatorcontrib><creatorcontrib>van Sandick, Johanna W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Der Sluis, Karen</au><au>Taylor, Steven N.</au><au>Kodach, Liudmila L.</au><au>van Dieren, Jolanda M.</au><au>de Hingh, Ignace H.J.T.</au><au>Wijnhoven, Bas P.L.</au><au>Verhoeven, Rob H.A.</au><au>Vollebergh, Marieke A.</au><au>van Sandick, Johanna W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor-positive peritoneal cytology in patients with gastric cancer is associated with poor outcome: A nationwide study</atitle><jtitle>European journal of cancer (1990)</jtitle><addtitle>Eur J Cancer</addtitle><date>2024-03</date><risdate>2024</risdate><volume>199</volume><spage>113541</spage><pages>113541-</pages><artnum>113541</artnum><issn>0959-8049</issn><issn>1879-0852</issn><eissn>1879-0852</eissn><abstract>The clinical significance of tumor-positive peritoneal cytology (CYT+) in gastric cancer (GC) patients is unclear. This nationwide cohort study aimed to i) assess the frequency of cytological analysis at staging laparoscopy; ii) determine the prevalence of CYT+GC; and iii) compare overall survival (OS) in CYT+ patients versus those with (PM+) and those without (PM-) macroscopic peritoneal disease.
All patients diagnosed with cT1–4, cN0–2 and M0 or synchronous PM GC between 2016–2021 were identified in the Netherlands Cancer Registry database and linked to the nationwide pathology database.
A total of 4397 patients was included, of which 40 % underwent cytological assessment following staging laparoscopy (863/1745). The prevalence of CYT+ was 8 %. A total of 69 patients had CYT+(1.6 %), 789 (17.9 %) had PM+ and 3539 (80.5 %) had PM- disease. Hazard ratio for OS in CYT+ versus PM+ was 0.86 (95 %CI 0.64–1.17, p-value=0.338), and in PM- versus PM+0.43 (95 %CI 0.38–0.49, p-value<0.001). No survival difference was found between systemic chemotherapy versus surgical resection in CYT+ patients.
In this nationwide study, OS for gastric cancer patients with CYT+ was equally unfavorable as for those with PM+ and significantly worse as compared to those with PM-. The optimal treatment strategy has yet to be established.
[Display omitted]
•Tumor-positive peritoneal cytology and PM in GC had a comparable dismal survival.•Surgery and systemic treatment in CYT+ patients showed equal survival figures.•Staging laparoscopy including cytology improves patient selection for GC therapy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38237371</pmid><doi>10.1016/j.ejca.2024.113541</doi></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Cohort Studies Cytodiagnosis Cytology Gastric cancer Humans Lavage Neoplasm Staging Peritoneal Lavage Peritoneal metastases Prognosis Staging laparoscopy Stomach Neoplasms - pathology |
| title | Tumor-positive peritoneal cytology in patients with gastric cancer is associated with poor outcome: A nationwide study |
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