IL-38 in Behçet's disease: Gene expression in bronchoalveolar lavage from patients having pulmonary involvement

•IL-38 was significantly decreased in active BD.•Patients with active BD with pulmonary manifestation, expressed decreased IL-38 mRNA.•Recombinant IL-38 played a regulatory role by suppressing IL-17 and NLRP3 inflammasome in vitro and enhancing IL-10 and TGFβ production in active BD.•Activation of t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2024-04, Vol.266, p.106840-106840, Article 106840
Hauptverfasser:	Hamzaoui, Kamel, Louhaichi, Sabrine, Salhi, Mariem, Sassi, Fayçal Haj, Laathar, Ahmed, Hamzaoui, Agnes
Format:	Artikel
Sprache:	eng
Schlagworte:	Behcet Syndrome - diagnosis Behcet Syndrome - genetics Behçet disease Biomarkers Bronchoalveolar Lavage Gene Expression Humans IL-1 family Inflammasomes Interleukin-10 - genetics Interleukin-17 - metabolism Interleukins - genetics Lung Diseases NLR Family, Pyrin Domain-Containing 3 Protein NLRP3 inflammasome Pulmonary involvement Transforming Growth Factor beta - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!