Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway
[Display omitted] Intranasal delivery provides a direct and non-invasive method for drugs to reach the central nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of brain delivery. However, the interaction between nanoparticles and the nose-to-brain pathway and...
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| Veröffentlicht in: | Advanced drug delivery reviews 2024-04, Vol.207, p.115196, Article 115196 |
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| container_title | Advanced drug delivery reviews |
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| creator | Chen, Yaoxing Zhang, Chenyun Huang, Yukun Ma, Yuxiao Song, Qingxiang Chen, Hongzhuan Jiang, Gan Gao, Xiaoling |
| description | [Display omitted]
Intranasal delivery provides a direct and non-invasive method for drugs to reach the central nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of brain delivery. However, the interaction between nanoparticles and the nose-to-brain pathway and how the various biopharmaceutical factors affect brain delivery efficacy remains unclear. In this review, we comprehensively summarized the anatomical and physiological characteristics of the nose-to-brain pathway and the obstacles that hinder brain delivery. We then outlined the interaction between nanoparticles and this pathway and reviewed the biomedical applications of various nanoparticulate drug delivery systems for nose-to-brain drug delivery. This review aims at inspiring innovative approaches for enhancing the effectiveness of nose-to-brain drug delivery in the treatment of different brain disorders. |
| doi_str_mv | 10.1016/j.addr.2024.115196 |
| format | Article |
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Intranasal delivery provides a direct and non-invasive method for drugs to reach the central nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of brain delivery. However, the interaction between nanoparticles and the nose-to-brain pathway and how the various biopharmaceutical factors affect brain delivery efficacy remains unclear. In this review, we comprehensively summarized the anatomical and physiological characteristics of the nose-to-brain pathway and the obstacles that hinder brain delivery. We then outlined the interaction between nanoparticles and this pathway and reviewed the biomedical applications of various nanoparticulate drug delivery systems for nose-to-brain drug delivery. This review aims at inspiring innovative approaches for enhancing the effectiveness of nose-to-brain drug delivery in the treatment of different brain disorders.</description><identifier>ISSN: 0169-409X</identifier><identifier>ISSN: 1872-8294</identifier><identifier>EISSN: 1872-8294</identifier><identifier>DOI: 10.1016/j.addr.2024.115196</identifier><identifier>PMID: 38336090</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Intranasal ; Biomimetic drug delivery systems ; Brain - metabolism ; Drug Delivery Systems - methods ; Humans ; Intranasal drug delivery ; Nanoparticles - metabolism ; Neurodegenerative diseases ; Nose-to-brain pathway ; Pharmaceutical Preparations - metabolism ; Synthesized drug delivery systems ; Target drug delivery</subject><ispartof>Advanced drug delivery reviews, 2024-04, Vol.207, p.115196, Article 115196</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-8653f2e690c505473a90e9718cc60c7e0112cbd1f2fd22c8bc98a18f6ce6d8c43</citedby><cites>FETCH-LOGICAL-c356t-8653f2e690c505473a90e9718cc60c7e0112cbd1f2fd22c8bc98a18f6ce6d8c43</cites><orcidid>0000-0001-6789-3059 ; 0000-0003-2632-3783 ; 0000-0003-2011-741X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0169409X24000188$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38336090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yaoxing</creatorcontrib><creatorcontrib>Zhang, Chenyun</creatorcontrib><creatorcontrib>Huang, Yukun</creatorcontrib><creatorcontrib>Ma, Yuxiao</creatorcontrib><creatorcontrib>Song, Qingxiang</creatorcontrib><creatorcontrib>Chen, Hongzhuan</creatorcontrib><creatorcontrib>Jiang, Gan</creatorcontrib><creatorcontrib>Gao, Xiaoling</creatorcontrib><title>Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway</title><title>Advanced drug delivery reviews</title><addtitle>Adv Drug Deliv Rev</addtitle><description>[Display omitted]
Intranasal delivery provides a direct and non-invasive method for drugs to reach the central nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of brain delivery. However, the interaction between nanoparticles and the nose-to-brain pathway and how the various biopharmaceutical factors affect brain delivery efficacy remains unclear. In this review, we comprehensively summarized the anatomical and physiological characteristics of the nose-to-brain pathway and the obstacles that hinder brain delivery. We then outlined the interaction between nanoparticles and this pathway and reviewed the biomedical applications of various nanoparticulate drug delivery systems for nose-to-brain drug delivery. This review aims at inspiring innovative approaches for enhancing the effectiveness of nose-to-brain drug delivery in the treatment of different brain disorders.</description><subject>Administration, Intranasal</subject><subject>Biomimetic drug delivery systems</subject><subject>Brain - metabolism</subject><subject>Drug Delivery Systems - methods</subject><subject>Humans</subject><subject>Intranasal drug delivery</subject><subject>Nanoparticles - metabolism</subject><subject>Neurodegenerative diseases</subject><subject>Nose-to-brain pathway</subject><subject>Pharmaceutical Preparations - metabolism</subject><subject>Synthesized drug delivery systems</subject><subject>Target drug delivery</subject><issn>0169-409X</issn><issn>1872-8294</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAURoMoOj7-gAvJ0k3HJG3TRNyI-ALBjYIbCenNrWbopGOSUebf22HUpau7Od-Bewg55mzKGZdns6l1Lk4FE9WU85pruUUmXDWiUEJX22QyQrqomH7ZI_spzRjjopFsl-yVqiwl02xCXu9DjjbYZHvq4vKNOuz9J8bVOX16R-pDxmgh-yHQFvMXYqDBhmFhY_bQY6I2OJpHMgwJizwUbbQ-0IXN7192dUh2OtsnPPq5B-T55vrp6q54eLy9v7p8KKCsZS6UrMtOoNQMalZXTWk1Q91wBSAZNMg4F9A63onOCQGqBa0sV50ElE5BVR6Q0413EYePJaZs5j4B9r0NOCyTEVrUrBob1SMqNijEIaWInVlEP7dxZTgz66xmZtZZzTqr2WQdRyc__mU7R_c3-e04AhcbAMcvPz1Gk8BjAHQ-ImTjBv-f_xsoc4mu</recordid><startdate>202404</startdate><enddate>202404</enddate><creator>Chen, Yaoxing</creator><creator>Zhang, Chenyun</creator><creator>Huang, Yukun</creator><creator>Ma, Yuxiao</creator><creator>Song, Qingxiang</creator><creator>Chen, Hongzhuan</creator><creator>Jiang, Gan</creator><creator>Gao, Xiaoling</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6789-3059</orcidid><orcidid>https://orcid.org/0000-0003-2632-3783</orcidid><orcidid>https://orcid.org/0000-0003-2011-741X</orcidid></search><sort><creationdate>202404</creationdate><title>Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway</title><author>Chen, Yaoxing ; Zhang, Chenyun ; Huang, Yukun ; Ma, Yuxiao ; Song, Qingxiang ; Chen, Hongzhuan ; Jiang, Gan ; Gao, Xiaoling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-8653f2e690c505473a90e9718cc60c7e0112cbd1f2fd22c8bc98a18f6ce6d8c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Administration, Intranasal</topic><topic>Biomimetic drug delivery systems</topic><topic>Brain - metabolism</topic><topic>Drug Delivery Systems - methods</topic><topic>Humans</topic><topic>Intranasal drug delivery</topic><topic>Nanoparticles - metabolism</topic><topic>Neurodegenerative diseases</topic><topic>Nose-to-brain pathway</topic><topic>Pharmaceutical Preparations - metabolism</topic><topic>Synthesized drug delivery systems</topic><topic>Target drug delivery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yaoxing</creatorcontrib><creatorcontrib>Zhang, Chenyun</creatorcontrib><creatorcontrib>Huang, Yukun</creatorcontrib><creatorcontrib>Ma, Yuxiao</creatorcontrib><creatorcontrib>Song, Qingxiang</creatorcontrib><creatorcontrib>Chen, Hongzhuan</creatorcontrib><creatorcontrib>Jiang, Gan</creatorcontrib><creatorcontrib>Gao, Xiaoling</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yaoxing</au><au>Zhang, Chenyun</au><au>Huang, Yukun</au><au>Ma, Yuxiao</au><au>Song, Qingxiang</au><au>Chen, Hongzhuan</au><au>Jiang, Gan</au><au>Gao, Xiaoling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2024-04</date><risdate>2024</risdate><volume>207</volume><spage>115196</spage><pages>115196-</pages><artnum>115196</artnum><issn>0169-409X</issn><issn>1872-8294</issn><eissn>1872-8294</eissn><abstract>[Display omitted]
Intranasal delivery provides a direct and non-invasive method for drugs to reach the central nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of brain delivery. However, the interaction between nanoparticles and the nose-to-brain pathway and how the various biopharmaceutical factors affect brain delivery efficacy remains unclear. In this review, we comprehensively summarized the anatomical and physiological characteristics of the nose-to-brain pathway and the obstacles that hinder brain delivery. We then outlined the interaction between nanoparticles and this pathway and reviewed the biomedical applications of various nanoparticulate drug delivery systems for nose-to-brain drug delivery. This review aims at inspiring innovative approaches for enhancing the effectiveness of nose-to-brain drug delivery in the treatment of different brain disorders.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38336090</pmid><doi>10.1016/j.addr.2024.115196</doi><orcidid>https://orcid.org/0000-0001-6789-3059</orcidid><orcidid>https://orcid.org/0000-0003-2632-3783</orcidid><orcidid>https://orcid.org/0000-0003-2011-741X</orcidid></addata></record> |
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| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2024-04, Vol.207, p.115196, Article 115196 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Intranasal Biomimetic drug delivery systems Brain - metabolism Drug Delivery Systems - methods Humans Intranasal drug delivery Nanoparticles - metabolism Neurodegenerative diseases Nose-to-brain pathway Pharmaceutical Preparations - metabolism Synthesized drug delivery systems Target drug delivery |
| title | Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway |
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