Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases
Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. During normal metabolism, the human body maintains copper homeostasis. Copper deficiency or excess can adversely affect cellular function. Therefore, copper homeostasis is stringen...
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| Veröffentlicht in: | Current medical science 2024-02, Vol.44 (1), p.28-50 |
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| creator | Ban, Xiao-xia Wan, Hao Wan, Xin-xing Tan, Ya-ting Hu, Xi-min Ban, Hong-xia Chen, Xin-yu Huang, Kun Zhang, Qi Xiong, Kun |
| description | Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. During normal metabolism, the human body maintains copper homeostasis. Copper deficiency or excess can adversely affect cellular function. Therefore, copper homeostasis is stringently regulated. Recent studies suggest that copper can trigger a specific form of cell death, namely, cuproptosis, which is triggered by excessive levels of intracellular copper. Cuproptosis induces the aggregation of mitochondrial lipoylated proteins, and the loss of iron-sulfur cluster proteins. In neurodegenerative diseases, the pathogenesis and progression of neurological disorders are linked to copper homeostasis. This review summarizes the advances in copper homeostasis and cuproptosis in the nervous system and neurodegenerative diseases. This offers research perspectives that provide new insights into the targeted treatment of neurodegenerative diseases based on cuproptosis. |
| doi_str_mv | 10.1007/s11596-024-2832-z |
| format | Article |
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This offers research perspectives that provide new insights into the targeted treatment of neurodegenerative diseases based on cuproptosis.</description><subject>Cell Death</subject><subject>Copper</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mitochondrial Proteins</subject><subject>Neurodegenerative Diseases - drug therapy</subject><subject>Review Article</subject><issn>2096-5230</issn><issn>2523-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kM1O3TAQRi1EBYjyAGxQlmxS_BPHNjt0gYIEhQVI7CzHHsAoNw6epFJ5eny5wLKr8XjOfNIcQvYZ_cUoVUfImDRtTXlTcy14_bZBdrjkotbGPGyWNy3T0tNtsocYOyoYbwXTfItsCy1Ea7TaIXmRxhFydQ2T61IfcVm5IVSLecxpnBJGPK6uUw9-7t2K8s9uKBB-UHfPkN0I8xR9dQsZR_BT_AtYxaH6A3NOAZ5gKMzqtzqNCA4Bf5Ifj65H2Pusu-T-_OxucVFf3fy-XJxc1V5oNdWSNh6E7rgRHQ_KA1Wd8iG0DZOMu9AZSSULhrWiUcopwZXi3msRvG4ClWKXHK5zyymvM-BklxE99L0bIM1oueGSCmkULyhboz4nxAyPdsxx6fI_y6hd2bZr27bYtivb9q3sHHzGz90SwvfGl9sC8DWAZTQ8QbYvac5DOfk_qe9-OIyy</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Ban, Xiao-xia</creator><creator>Wan, Hao</creator><creator>Wan, Xin-xing</creator><creator>Tan, Ya-ting</creator><creator>Hu, Xi-min</creator><creator>Ban, Hong-xia</creator><creator>Chen, Xin-yu</creator><creator>Huang, Kun</creator><creator>Zhang, Qi</creator><creator>Xiong, Kun</creator><general>Huazhong University of Science and Technology</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240201</creationdate><title>Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases</title><author>Ban, Xiao-xia ; Wan, Hao ; Wan, Xin-xing ; Tan, Ya-ting ; Hu, Xi-min ; Ban, Hong-xia ; Chen, Xin-yu ; Huang, Kun ; Zhang, Qi ; Xiong, Kun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-504ce38b293b2d7ce07b7cdd641512adb95051d9163477a732772cc83dc84d053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cell Death</topic><topic>Copper</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mitochondrial Proteins</topic><topic>Neurodegenerative Diseases - drug therapy</topic><topic>Review Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ban, Xiao-xia</creatorcontrib><creatorcontrib>Wan, Hao</creatorcontrib><creatorcontrib>Wan, Xin-xing</creatorcontrib><creatorcontrib>Tan, Ya-ting</creatorcontrib><creatorcontrib>Hu, Xi-min</creatorcontrib><creatorcontrib>Ban, Hong-xia</creatorcontrib><creatorcontrib>Chen, Xin-yu</creatorcontrib><creatorcontrib>Huang, Kun</creatorcontrib><creatorcontrib>Zhang, Qi</creatorcontrib><creatorcontrib>Xiong, Kun</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ban, Xiao-xia</au><au>Wan, Hao</au><au>Wan, Xin-xing</au><au>Tan, Ya-ting</au><au>Hu, Xi-min</au><au>Ban, Hong-xia</au><au>Chen, Xin-yu</au><au>Huang, Kun</au><au>Zhang, Qi</au><au>Xiong, Kun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases</atitle><jtitle>Current medical science</jtitle><stitle>CURR MED SCI</stitle><addtitle>Curr Med Sci</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>44</volume><issue>1</issue><spage>28</spage><epage>50</epage><pages>28-50</pages><issn>2096-5230</issn><eissn>2523-899X</eissn><abstract>Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. 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| subjects | Cell Death Copper Humans Medicine Medicine & Public Health Mitochondrial Proteins Neurodegenerative Diseases - drug therapy Review Article |
| title | Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases |
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