TRPA1-PI3K/Akt-OPA1-ferroptosis axis in ozone-induced bronchial epithelial cell and lung injury

Transient receptor potential (TRP) ankyrin 1 (TRPA1) could mediate ozone-induced lung injury. Optic Atrophy 1 (OPA1) is one of the significant mitochondrial fusion proteins. Impaired mitochondrial fusion, resulting in mitochondrial dysfunction and ferroptosis, may drive the onset and progression of...

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Veröffentlicht in:	The Science of the total environment 2024-03, Vol.918, p.170668-170668, Article 170668
Hauptverfasser:	Weng, Jiali, Liu, Qi, Li, Chenfei, Feng, Yi, Chang, Qing, Xie, Meiqin, Wang, Xiaohui, Li, Mengnan, Zhang, Hai, Mao, Ruolin, Zhang, Na, Yang, Xiaohua, Chung, Kian Fan, Adcock, Ian M, Huang, Yan, Li, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	atrophy environment epithelial cells epithelium Ferroptosis genes humans inflammation lungs mice mitochondria Mitochondrial fusion OPA1 oxidative stress Ozone PI3K/Akt transcriptome TRPA1
Online-Zugang:	Volltext
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