Antiviral and Antibacterial 3D-Printed Products Functionalised with Poly(hexamethylene biguanide)
Infection prevention and public health are a vital concern worldwide, especially during pandemics such as COVID-19 and seasonal influenza. Frequent manual disinfection and use of chemical spray coatings at public facilities are the typical measures taken to protect people from coronaviruses and othe...
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| Veröffentlicht in: | Polymers 2024-01, Vol.16 (3), p.312 |
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| creator | Luk, Anson M Y Lo, Chris K Y Chiou, Jiachi Amber Ngai, Chi-Hang Law, Ki Lau, Tsz-Long Chen, Wan-Xue Hui, Matthew Kan, Chi-Wai |
| description | Infection prevention and public health are a vital concern worldwide, especially during pandemics such as COVID-19 and seasonal influenza. Frequent manual disinfection and use of chemical spray coatings at public facilities are the typical measures taken to protect people from coronaviruses and other pathogens. However, limitations of human resources and coating durability, as well as the safety of disinfectants used are the major concerns in society during a pandemic. Non-leachable antimicrobial agent poly(hexamethylene biguanide) (PHMB) was mixed into photocurable liquid resins to produce novel and tailor-made covers for public facilities via digital light processing, which is a popular 3D printing technique for satisfactory printing resolution. Potent efficacies of the 3D-printed plastics were achieved in standard antibacterial assessments against
,
and
. A total of 99.9% of Human coronavirus 229E was killed after being in contact with the 3D-printed samples (containing the promising PHMB formulation) for two hours. In an eight-week field test in Hong Kong Wetland Park, antibacterial performances of the specially designed 3D-printed covers analysed by environmental swabbing were also found to be satisfactory. With these remarkable outcomes, antimicrobial products prepared by digital light processing 3D printing can be regarded as a reliable solution to long-term infection prevention and control. |
| doi_str_mv | 10.3390/polym16030312 |
| format | Article |
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,
and
. A total of 99.9% of Human coronavirus 229E was killed after being in contact with the 3D-printed samples (containing the promising PHMB formulation) for two hours. In an eight-week field test in Hong Kong Wetland Park, antibacterial performances of the specially designed 3D-printed covers analysed by environmental swabbing were also found to be satisfactory. With these remarkable outcomes, antimicrobial products prepared by digital light processing 3D printing can be regarded as a reliable solution to long-term infection prevention and control.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym16030312</identifier><identifier>PMID: 38337200</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>3-D printers ; 3D printing ; Analysis ; Antiinfectives and antibacterials ; Antimicrobial agents ; Composite materials ; Coronaviruses ; COVID-19 ; Cyclohexane ; E coli ; Field tests ; Households ; Identification and classification ; Molecular weight ; Nanoparticles ; Pandemics ; Pathogens ; Polyhexanide ; Polymers ; Properties ; Public health ; Resins ; Silver ; Testing laboratories ; Three dimensional printing</subject><ispartof>Polymers, 2024-01, Vol.16 (3), p.312</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c383t-e70cf1a957834075c3b03ea3c3459229f6fc982bc9897090620f54bf17a2902a3</cites><orcidid>0000-0001-8404-4630 ; 0000-0001-8306-1826 ; 0000-0003-0697-0051 ; 0000-0002-7668-2410</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38337200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luk, Anson M Y</creatorcontrib><creatorcontrib>Lo, Chris K Y</creatorcontrib><creatorcontrib>Chiou, Jiachi Amber</creatorcontrib><creatorcontrib>Ngai, Chi-Hang</creatorcontrib><creatorcontrib>Law, Ki</creatorcontrib><creatorcontrib>Lau, Tsz-Long</creatorcontrib><creatorcontrib>Chen, Wan-Xue</creatorcontrib><creatorcontrib>Hui, Matthew</creatorcontrib><creatorcontrib>Kan, Chi-Wai</creatorcontrib><title>Antiviral and Antibacterial 3D-Printed Products Functionalised with Poly(hexamethylene biguanide)</title><title>Polymers</title><addtitle>Polymers (Basel)</addtitle><description>Infection prevention and public health are a vital concern worldwide, especially during pandemics such as COVID-19 and seasonal influenza. Frequent manual disinfection and use of chemical spray coatings at public facilities are the typical measures taken to protect people from coronaviruses and other pathogens. However, limitations of human resources and coating durability, as well as the safety of disinfectants used are the major concerns in society during a pandemic. Non-leachable antimicrobial agent poly(hexamethylene biguanide) (PHMB) was mixed into photocurable liquid resins to produce novel and tailor-made covers for public facilities via digital light processing, which is a popular 3D printing technique for satisfactory printing resolution. Potent efficacies of the 3D-printed plastics were achieved in standard antibacterial assessments against
,
and
. A total of 99.9% of Human coronavirus 229E was killed after being in contact with the 3D-printed samples (containing the promising PHMB formulation) for two hours. In an eight-week field test in Hong Kong Wetland Park, antibacterial performances of the specially designed 3D-printed covers analysed by environmental swabbing were also found to be satisfactory. With these remarkable outcomes, antimicrobial products prepared by digital light processing 3D printing can be regarded as a reliable solution to long-term infection prevention and control.</description><subject>3-D printers</subject><subject>3D printing</subject><subject>Analysis</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Composite materials</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Cyclohexane</subject><subject>E coli</subject><subject>Field tests</subject><subject>Households</subject><subject>Identification and classification</subject><subject>Molecular weight</subject><subject>Nanoparticles</subject><subject>Pandemics</subject><subject>Pathogens</subject><subject>Polyhexanide</subject><subject>Polymers</subject><subject>Properties</subject><subject>Public health</subject><subject>Resins</subject><subject>Silver</subject><subject>Testing laboratories</subject><subject>Three dimensional printing</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkc1v1DAQxSMEolXbI1cUiUs5pJ14nDg-rgoFpErsoZwjxxl3XSX2YjvA_vf1tuWjqLbkj6ffjJ79iuJNDWeIEs63ftrNdQsIWLMXxSEDgRXHFl7-cz4oTmK8hTx407a1eF0cYIcoGMBhoVYu2R82qKlUbiz3t0HpRMFmBT9U62BdorFcBz8uOsXycnE6We_UZGPWf9q0KdfZxumGfqmZ0mY3kaNysDeLcnak98fFK6OmSCeP-1Hx7fLj9cXn6urrpy8Xq6tKZzepIgHa1Eo2okMOotE4AJJCjbyRjEnTGi07NuRFCpDQMjANH0wtFJPAFB4Vpw99t8F_XyimfrZR0zQpR36JPZOsAeT5RzL67j_01i8hP-meQik6zuu_1I2aqLfO-BSU3jftV6JjkEnkmTp7hspzpNlq78jYrD8pqB4KdPAxBjL9NthZhV1fQ79PtX-SaubfPppdhpnGP_TvDPEOdDya9Q</recordid><startdate>20240123</startdate><enddate>20240123</enddate><creator>Luk, Anson M Y</creator><creator>Lo, Chris K Y</creator><creator>Chiou, Jiachi Amber</creator><creator>Ngai, Chi-Hang</creator><creator>Law, Ki</creator><creator>Lau, Tsz-Long</creator><creator>Chen, Wan-Xue</creator><creator>Hui, Matthew</creator><creator>Kan, Chi-Wai</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8404-4630</orcidid><orcidid>https://orcid.org/0000-0001-8306-1826</orcidid><orcidid>https://orcid.org/0000-0003-0697-0051</orcidid><orcidid>https://orcid.org/0000-0002-7668-2410</orcidid></search><sort><creationdate>20240123</creationdate><title>Antiviral and Antibacterial 3D-Printed Products Functionalised with Poly(hexamethylene biguanide)</title><author>Luk, Anson M Y ; Lo, Chris K Y ; Chiou, Jiachi Amber ; Ngai, Chi-Hang ; Law, Ki ; Lau, Tsz-Long ; Chen, Wan-Xue ; Hui, Matthew ; Kan, Chi-Wai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-e70cf1a957834075c3b03ea3c3459229f6fc982bc9897090620f54bf17a2902a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>3-D printers</topic><topic>3D printing</topic><topic>Analysis</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial agents</topic><topic>Composite materials</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Cyclohexane</topic><topic>E coli</topic><topic>Field tests</topic><topic>Households</topic><topic>Identification and classification</topic><topic>Molecular weight</topic><topic>Nanoparticles</topic><topic>Pandemics</topic><topic>Pathogens</topic><topic>Polyhexanide</topic><topic>Polymers</topic><topic>Properties</topic><topic>Public health</topic><topic>Resins</topic><topic>Silver</topic><topic>Testing laboratories</topic><topic>Three dimensional printing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luk, Anson M Y</creatorcontrib><creatorcontrib>Lo, Chris K Y</creatorcontrib><creatorcontrib>Chiou, Jiachi Amber</creatorcontrib><creatorcontrib>Ngai, Chi-Hang</creatorcontrib><creatorcontrib>Law, Ki</creatorcontrib><creatorcontrib>Lau, Tsz-Long</creatorcontrib><creatorcontrib>Chen, Wan-Xue</creatorcontrib><creatorcontrib>Hui, Matthew</creatorcontrib><creatorcontrib>Kan, Chi-Wai</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luk, Anson M Y</au><au>Lo, Chris K Y</au><au>Chiou, Jiachi Amber</au><au>Ngai, Chi-Hang</au><au>Law, Ki</au><au>Lau, Tsz-Long</au><au>Chen, Wan-Xue</au><au>Hui, Matthew</au><au>Kan, Chi-Wai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiviral and Antibacterial 3D-Printed Products Functionalised with Poly(hexamethylene biguanide)</atitle><jtitle>Polymers</jtitle><addtitle>Polymers (Basel)</addtitle><date>2024-01-23</date><risdate>2024</risdate><volume>16</volume><issue>3</issue><spage>312</spage><pages>312-</pages><issn>2073-4360</issn><eissn>2073-4360</eissn><abstract>Infection prevention and public health are a vital concern worldwide, especially during pandemics such as COVID-19 and seasonal influenza. Frequent manual disinfection and use of chemical spray coatings at public facilities are the typical measures taken to protect people from coronaviruses and other pathogens. However, limitations of human resources and coating durability, as well as the safety of disinfectants used are the major concerns in society during a pandemic. Non-leachable antimicrobial agent poly(hexamethylene biguanide) (PHMB) was mixed into photocurable liquid resins to produce novel and tailor-made covers for public facilities via digital light processing, which is a popular 3D printing technique for satisfactory printing resolution. Potent efficacies of the 3D-printed plastics were achieved in standard antibacterial assessments against
,
and
. A total of 99.9% of Human coronavirus 229E was killed after being in contact with the 3D-printed samples (containing the promising PHMB formulation) for two hours. In an eight-week field test in Hong Kong Wetland Park, antibacterial performances of the specially designed 3D-printed covers analysed by environmental swabbing were also found to be satisfactory. With these remarkable outcomes, antimicrobial products prepared by digital light processing 3D printing can be regarded as a reliable solution to long-term infection prevention and control.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38337200</pmid><doi>10.3390/polym16030312</doi><orcidid>https://orcid.org/0000-0001-8404-4630</orcidid><orcidid>https://orcid.org/0000-0001-8306-1826</orcidid><orcidid>https://orcid.org/0000-0003-0697-0051</orcidid><orcidid>https://orcid.org/0000-0002-7668-2410</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Polymers, 2024-01, Vol.16 (3), p.312 |
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| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | 3-D printers 3D printing Analysis Antiinfectives and antibacterials Antimicrobial agents Composite materials Coronaviruses COVID-19 Cyclohexane E coli Field tests Households Identification and classification Molecular weight Nanoparticles Pandemics Pathogens Polyhexanide Polymers Properties Public health Resins Silver Testing laboratories Three dimensional printing |
| title | Antiviral and Antibacterial 3D-Printed Products Functionalised with Poly(hexamethylene biguanide) |
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