Timing and Location of Venous Thromboembolisms After Surgery for Inflammatory Bowel Disease
Patients with inflammatory bowel disease are reported to be at elevated risk for postoperative venous thromboembolism (VTE). The rate and location of these VTE complications is unclear. Patients with ulcerative colitis (UC) or Crohn’s disease (CD) undergoing intestinal operations between January 200...
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| Veröffentlicht in: | The Journal of surgical research 2024-04, Vol.296, p.563-570 |
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| container_title | The Journal of surgical research |
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| creator | McKenna, Nicholas P. Bews, Katherine A. Behm, Kevin T. Mathis, Kellie L. Cima, Robert R. Habermann, Elizabeth B. |
| description | Patients with inflammatory bowel disease are reported to be at elevated risk for postoperative venous thromboembolism (VTE). The rate and location of these VTE complications is unclear.
Patients with ulcerative colitis (UC) or Crohn’s disease (CD) undergoing intestinal operations between January 2006 and March 2021 were identified from the medical record at a single institution. The overall incidence of VTEs and their anatomic location were determined to 90 days postoperatively.
In 2716 operations in patients with UC, VTE prevalence was 1.95% at 1-30 days, 0.74% at 31-60 days, and 0.48% at 90 days (P |
| doi_str_mv | 10.1016/j.jss.2024.01.033 |
| format | Article |
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Patients with ulcerative colitis (UC) or Crohn’s disease (CD) undergoing intestinal operations between January 2006 and March 2021 were identified from the medical record at a single institution. The overall incidence of VTEs and their anatomic location were determined to 90 days postoperatively.
In 2716 operations in patients with UC, VTE prevalence was 1.95% at 1-30 days, 0.74% at 31-60 days, and 0.48% at 90 days (P < 0.0001). Seventy two percent of VTEs within the first 30 days were in the portomesenteric system, and this remained the location for the majority of VTE events at 31-60 and 61-90 days postoperatively. In the first 30 days, proctectomies had the highest incidence of VTEs (2.5%) in patients with UC. In 2921 operations in patients with CD, VTE prevalence was 1.43%, 0.55%, and 0.41% at 1-30 days, 31-60 days, and 61-90 days, respectively (P < 0.0001). Portomesenteric VTEs accounted for 31% of all VTEs within 30 days postoperatively. In the first 30 days, total abdominal colectomies had the highest incidence of VTEs (2.5%) in patients with CD.
The majority of VTEs within 90 days of surgery for UC and Crohn’s are diagnosed within the first 30 days. The risk of a VTE varies by the extent of the operation performed, with portomesenteric VTE representing a substantial proportion of events.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/j.jss.2024.01.033</identifier><identifier>PMID: 38340490</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Crohn’s disease ; Inflammatory bowel disease ; Ulcerative colitis ; Venous thromboembolism</subject><ispartof>The Journal of surgical research, 2024-04, Vol.296, p.563-570</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c305t-a431045ad392ddb7b513f9e6c2dd94a13ede309e6eed4cdb267c0c12508f5e603</cites><orcidid>0000-0001-6346-8370</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022480424000544$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38340490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McKenna, Nicholas P.</creatorcontrib><creatorcontrib>Bews, Katherine A.</creatorcontrib><creatorcontrib>Behm, Kevin T.</creatorcontrib><creatorcontrib>Mathis, Kellie L.</creatorcontrib><creatorcontrib>Cima, Robert R.</creatorcontrib><creatorcontrib>Habermann, Elizabeth B.</creatorcontrib><title>Timing and Location of Venous Thromboembolisms After Surgery for Inflammatory Bowel Disease</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>Patients with inflammatory bowel disease are reported to be at elevated risk for postoperative venous thromboembolism (VTE). The rate and location of these VTE complications is unclear.
Patients with ulcerative colitis (UC) or Crohn’s disease (CD) undergoing intestinal operations between January 2006 and March 2021 were identified from the medical record at a single institution. The overall incidence of VTEs and their anatomic location were determined to 90 days postoperatively.
In 2716 operations in patients with UC, VTE prevalence was 1.95% at 1-30 days, 0.74% at 31-60 days, and 0.48% at 90 days (P < 0.0001). Seventy two percent of VTEs within the first 30 days were in the portomesenteric system, and this remained the location for the majority of VTE events at 31-60 and 61-90 days postoperatively. In the first 30 days, proctectomies had the highest incidence of VTEs (2.5%) in patients with UC. In 2921 operations in patients with CD, VTE prevalence was 1.43%, 0.55%, and 0.41% at 1-30 days, 31-60 days, and 61-90 days, respectively (P < 0.0001). Portomesenteric VTEs accounted for 31% of all VTEs within 30 days postoperatively. In the first 30 days, total abdominal colectomies had the highest incidence of VTEs (2.5%) in patients with CD.
The majority of VTEs within 90 days of surgery for UC and Crohn’s are diagnosed within the first 30 days. The risk of a VTE varies by the extent of the operation performed, with portomesenteric VTE representing a substantial proportion of events.</description><subject>Crohn’s disease</subject><subject>Inflammatory bowel disease</subject><subject>Ulcerative colitis</subject><subject>Venous thromboembolism</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPwzAQhC0EouXxA7ggH7kkrGMnbcQJylOqxIHChYPl2JviKonBTkD8e1y1cOSwWu3qm5FmCDlhkDJgxfkqXYWQZpCJFFgKnO-QMYMyT6bFhO-SMUCWJWIKYkQOQlhBvMsJ3ycjPuUCRAlj8rqwre2WVHWGzp1WvXUddTV9wc4NgS7evGsrh3EaG9pAL-sePX0a_BL9N62dpw9d3ai2Vb2Ljyv3hQ29tgFVwCOyV6sm4PF2H5Ln25vF7D6ZP949zC7nieaQ94kSnIHIleFlZkw1qXLG6xILHa9SKMbRIIf4QDRCmyorJho0y3KY1jkWwA_J2cb33buPAUMvWxs0No3qMIaQWRlZHt3ziLINqr0LwWMt371tlf-WDOS6U7mSsVO57lQCk1EWNadb-6Fq0fwpfkuMwMUGwBjy06KXQVvsNBrrUffSOPuP_Q_Wo4gV</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>McKenna, Nicholas P.</creator><creator>Bews, Katherine A.</creator><creator>Behm, Kevin T.</creator><creator>Mathis, Kellie L.</creator><creator>Cima, Robert R.</creator><creator>Habermann, Elizabeth B.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6346-8370</orcidid></search><sort><creationdate>20240401</creationdate><title>Timing and Location of Venous Thromboembolisms After Surgery for Inflammatory Bowel Disease</title><author>McKenna, Nicholas P. ; Bews, Katherine A. ; Behm, Kevin T. ; Mathis, Kellie L. ; Cima, Robert R. ; Habermann, Elizabeth B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-a431045ad392ddb7b513f9e6c2dd94a13ede309e6eed4cdb267c0c12508f5e603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Crohn’s disease</topic><topic>Inflammatory bowel disease</topic><topic>Ulcerative colitis</topic><topic>Venous thromboembolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McKenna, Nicholas P.</creatorcontrib><creatorcontrib>Bews, Katherine A.</creatorcontrib><creatorcontrib>Behm, Kevin T.</creatorcontrib><creatorcontrib>Mathis, Kellie L.</creatorcontrib><creatorcontrib>Cima, Robert R.</creatorcontrib><creatorcontrib>Habermann, Elizabeth B.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McKenna, Nicholas P.</au><au>Bews, Katherine A.</au><au>Behm, Kevin T.</au><au>Mathis, Kellie L.</au><au>Cima, Robert R.</au><au>Habermann, Elizabeth B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Timing and Location of Venous Thromboembolisms After Surgery for Inflammatory Bowel Disease</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>296</volume><spage>563</spage><epage>570</epage><pages>563-570</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><abstract>Patients with inflammatory bowel disease are reported to be at elevated risk for postoperative venous thromboembolism (VTE). The rate and location of these VTE complications is unclear.
Patients with ulcerative colitis (UC) or Crohn’s disease (CD) undergoing intestinal operations between January 2006 and March 2021 were identified from the medical record at a single institution. The overall incidence of VTEs and their anatomic location were determined to 90 days postoperatively.
In 2716 operations in patients with UC, VTE prevalence was 1.95% at 1-30 days, 0.74% at 31-60 days, and 0.48% at 90 days (P < 0.0001). Seventy two percent of VTEs within the first 30 days were in the portomesenteric system, and this remained the location for the majority of VTE events at 31-60 and 61-90 days postoperatively. In the first 30 days, proctectomies had the highest incidence of VTEs (2.5%) in patients with UC. In 2921 operations in patients with CD, VTE prevalence was 1.43%, 0.55%, and 0.41% at 1-30 days, 31-60 days, and 61-90 days, respectively (P < 0.0001). Portomesenteric VTEs accounted for 31% of all VTEs within 30 days postoperatively. In the first 30 days, total abdominal colectomies had the highest incidence of VTEs (2.5%) in patients with CD.
The majority of VTEs within 90 days of surgery for UC and Crohn’s are diagnosed within the first 30 days. The risk of a VTE varies by the extent of the operation performed, with portomesenteric VTE representing a substantial proportion of events.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38340490</pmid><doi>10.1016/j.jss.2024.01.033</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6346-8370</orcidid></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Crohn’s disease Inflammatory bowel disease Ulcerative colitis Venous thromboembolism |
| title | Timing and Location of Venous Thromboembolisms After Surgery for Inflammatory Bowel Disease |
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