Lysyl Oxidase Regulates Epithelial Differentiation and Barrier Integrity in Eosinophilic Esophagitis

Epithelial disruption in eosinophilic esophagitis (EoE) encompasses both impaired differentiation and diminished barrier integrity. We have shown that lysyl oxidase (LOX), a collagen cross-linking enzyme, is up-regulated in the esophageal epithelium in EoE. However, the functional roles of LOX in th...

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Veröffentlicht in:	Cellular and molecular gastroenterology and hepatology 2024-01, Vol.17 (6), p.923-937
Hauptverfasser:	Sasaki, Masaru, Hara, Takeo, Wang, Joshua X., Zhou, Yusen, Kennedy, Kanak V., Umeweni, Chizoba N., Alston, Maiya A., Spergel, Zachary C., Ishikawa, Satoshi, Teranishi, Ryugo, Nakagawa, Ritsu, Mcmillan, Emily A., Whelan, Kelly A., Karakasheva, Tatiana A., Hamilton, Kathryn E., Ruffner, Melanie A., Muir, Amanda B.
Format:	Artikel
Sprache:	eng
Schlagworte:	BMP Eosinophilic Esophagitis Lysyl Oxidase Organoid
Online-Zugang:	Volltext
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