CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-β Signaling

Pulmonary fibrosis is a fatal condition characterized by fibroblast and myofibroblast proliferation and collagen deposition. TGF-β plays a pivotal role in the development of pulmonary fibrosis. Therefore, modulation of TGF-β signaling is a promising therapeutic strategy for treating pulmonary fibros...

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Veröffentlicht in:	The Journal of immunology (1950) 2024-04, Vol.212 (7), p.1221-1231
Hauptverfasser:	Naoi, Hyogo, Suzuki, Yuzo, Miyagi, Asuka, Horiguchi, Ryo, Aono, Yuya, Inoue, Yusuke, Yasui, Hideki, Hozumi, Hironao, Karayama, Masato, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, Inui, Naoki, Mii, Shinji, Ichihara, Masatoshi, Takahashi, Masahide, Suda, Takafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism Bleomycin - adverse effects Fibroblasts - metabolism GPI-Linked Proteins - metabolism Humans Lung - pathology Mice Mice, Inbred C57BL Mice, Transgenic Neoplasm Proteins - metabolism Pulmonary Fibrosis - metabolism Transcription Factors - metabolism Transforming Growth Factor beta - metabolism
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