Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease

The glucagon receptor (GCGR) in the kidney is expressed in nephron tubules. In humans and animal models with chronic kidney disease, renal GCGR expression is reduced. However, the role of kidney GCGR in normal renal function and in disease development has not been addressed. Here, we examined its ro...

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Veröffentlicht in:	Cell metabolism 2024-03, Vol.36 (3), p.575-597.e7
Hauptverfasser:	Wang, May-Yun, Zhang, Zhuzhen, Zhao, Shangang, Onodera, Toshiharu, Sun, Xue-Nan, Zhu, Qingzhang, Li, Chao, Li, Na, Chen, Shiuhwei, Paredes, Megan, Gautron, Laurent, Charron, Maureen J., Marciano, Denise K., Gordillo, Ruth, Drucker, Daniel J., Scherer, Philipp E.
Format:	Artikel
Sprache:	eng
Schlagworte:	chronic kidney disease glucagon receptor kidney
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