Au/PANI@PtCu-based electrochemical immunosensor for ultrasensitive determination of pro-gastrin-releasing peptide
An ultrasensitive sandwich-type electrochemical immunosensor for pro-gastrin-releasing peptide (ProGRP) detection was constructed based on PtCu nanodendrites functionalized Au/polyaniline nanospheres (Au/PANI@PtCu). The prepared Au/PANI@PtCu nanocomposites not only possessed excellent electro-cataly...
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| Veröffentlicht in: | Mikrochimica acta (1966) 2024-03, Vol.191 (3), p.126-126, Article 126 |
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| container_title | Mikrochimica acta (1966) |
| container_volume | 191 |
| creator | Fu, Xuhuai Gao, Ke Liu, Nanjing Guo, Bianqin He, Meng Lai, Nianyu Li, Xinyu Ding, Shijia He, Xiaoyan Wu, Lixiang |
| description | An ultrasensitive sandwich-type electrochemical immunosensor for pro-gastrin-releasing peptide (ProGRP) detection was constructed based on PtCu nanodendrites functionalized Au/polyaniline nanospheres (Au/PANI@PtCu). The prepared Au/PANI@PtCu nanocomposites not only possessed excellent electro-catalytic activity of H
2
O
2
reduction due to the synergistic effect between the Au/PANI and PtCu NDs but also provided large specific surface area for detection of antibodies (Ab
2
) immobilization. In addition, Au nanoparticles encapsulated multi-wall carbon nanotubes (AuNPs@MWCNTs) were also applied to modify the glassy carbon electrode interface for loading numerous capture antibodies (Ab
1
). In the presence of target ProGRP, a sandwich-type electrochemical immunosensor showed a strong current response from the electro-catalysis of Au/PANI@PtCu toward H
2
O
2
reduction. Benefiting from the exceptional electro-catalytic performance of Au/PANI@PtCu and the high conductivity of AuNPs@MWCNTs, the sandwich-type immunoassay exhibited remarkable sensitivity in detection. The linear range extended from 100 fg/mL to 10 ng/mL, while achieving an impressively low limit of detection of 77.62 fg/mL.
Graphical Abstract |
| doi_str_mv | 10.1007/s00604-023-06168-1 |
| format | Article |
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2
O
2
reduction due to the synergistic effect between the Au/PANI and PtCu NDs but also provided large specific surface area for detection of antibodies (Ab
2
) immobilization. In addition, Au nanoparticles encapsulated multi-wall carbon nanotubes (AuNPs@MWCNTs) were also applied to modify the glassy carbon electrode interface for loading numerous capture antibodies (Ab
1
). In the presence of target ProGRP, a sandwich-type electrochemical immunosensor showed a strong current response from the electro-catalysis of Au/PANI@PtCu toward H
2
O
2
reduction. Benefiting from the exceptional electro-catalytic performance of Au/PANI@PtCu and the high conductivity of AuNPs@MWCNTs, the sandwich-type immunoassay exhibited remarkable sensitivity in detection. The linear range extended from 100 fg/mL to 10 ng/mL, while achieving an impressively low limit of detection of 77.62 fg/mL.
Graphical Abstract</description><identifier>ISSN: 0026-3672</identifier><identifier>EISSN: 1436-5073</identifier><identifier>DOI: 10.1007/s00604-023-06168-1</identifier><identifier>PMID: 38332145</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Analytical Chemistry ; Antibodies ; Antibodies, Immobilized ; Biosensing Techniques ; Catalysis ; Catalytic activity ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Gastrin-Releasing Peptide ; Glassy carbon ; Gold ; Hydrogen Peroxide ; Immunoassay ; Immunosensors ; Intermetallic compounds ; Metal Nanoparticles ; Microengineering ; Multi wall carbon nanotubes ; Nanochemistry ; Nanocomposites ; Nanospheres ; Nanotechnology ; Nanotubes, Carbon ; Original Paper ; Polyanilines ; Reduction ; Synergistic effect</subject><ispartof>Mikrochimica acta (1966), 2024-03, Vol.191 (3), p.126-126, Article 126</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-cca942c82c40e03bc3097b5a16548580ff9eed43db9efa8d0d1d91addc269fa93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00604-023-06168-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00604-023-06168-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38332145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Xuhuai</creatorcontrib><creatorcontrib>Gao, Ke</creatorcontrib><creatorcontrib>Liu, Nanjing</creatorcontrib><creatorcontrib>Guo, Bianqin</creatorcontrib><creatorcontrib>He, Meng</creatorcontrib><creatorcontrib>Lai, Nianyu</creatorcontrib><creatorcontrib>Li, Xinyu</creatorcontrib><creatorcontrib>Ding, Shijia</creatorcontrib><creatorcontrib>He, Xiaoyan</creatorcontrib><creatorcontrib>Wu, Lixiang</creatorcontrib><title>Au/PANI@PtCu-based electrochemical immunosensor for ultrasensitive determination of pro-gastrin-releasing peptide</title><title>Mikrochimica acta (1966)</title><addtitle>Microchim Acta</addtitle><addtitle>Mikrochim Acta</addtitle><description>An ultrasensitive sandwich-type electrochemical immunosensor for pro-gastrin-releasing peptide (ProGRP) detection was constructed based on PtCu nanodendrites functionalized Au/polyaniline nanospheres (Au/PANI@PtCu). The prepared Au/PANI@PtCu nanocomposites not only possessed excellent electro-catalytic activity of H
2
O
2
reduction due to the synergistic effect between the Au/PANI and PtCu NDs but also provided large specific surface area for detection of antibodies (Ab
2
) immobilization. In addition, Au nanoparticles encapsulated multi-wall carbon nanotubes (AuNPs@MWCNTs) were also applied to modify the glassy carbon electrode interface for loading numerous capture antibodies (Ab
1
). In the presence of target ProGRP, a sandwich-type electrochemical immunosensor showed a strong current response from the electro-catalysis of Au/PANI@PtCu toward H
2
O
2
reduction. Benefiting from the exceptional electro-catalytic performance of Au/PANI@PtCu and the high conductivity of AuNPs@MWCNTs, the sandwich-type immunoassay exhibited remarkable sensitivity in detection. The linear range extended from 100 fg/mL to 10 ng/mL, while achieving an impressively low limit of detection of 77.62 fg/mL.
Graphical Abstract</description><subject>Analytical Chemistry</subject><subject>Antibodies</subject><subject>Antibodies, Immobilized</subject><subject>Biosensing Techniques</subject><subject>Catalysis</subject><subject>Catalytic activity</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Gastrin-Releasing Peptide</subject><subject>Glassy carbon</subject><subject>Gold</subject><subject>Hydrogen Peroxide</subject><subject>Immunoassay</subject><subject>Immunosensors</subject><subject>Intermetallic compounds</subject><subject>Metal Nanoparticles</subject><subject>Microengineering</subject><subject>Multi wall carbon nanotubes</subject><subject>Nanochemistry</subject><subject>Nanocomposites</subject><subject>Nanospheres</subject><subject>Nanotechnology</subject><subject>Nanotubes, Carbon</subject><subject>Original Paper</subject><subject>Polyanilines</subject><subject>Reduction</subject><subject>Synergistic effect</subject><issn>0026-3672</issn><issn>1436-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EotvCH-CAInHhYjr-iBPfWK2gVKqgBzhbjj1ZXCXx1nYq8e_xsgUkDhyskeVnXo_mIeQVg3cMoLvMAAokBS4oKKZ6yp6QDZNC0RY68ZRsALiiQnX8jJznfAfAOsXlc3ImeiE4k-2G3G_Xy9vt5-v3t2W30sFm9A1O6EqK7jvOwdmpCfO8LjHjkmNqxnrWqSR7vIcSHrDxWDDNYbElxKWJY3NIke5tLiksNNU0m8Oybw54KMHjC_JstFPGl4_1gnz7-OHr7hO9-XJ1vdveUCe4KtQ5qyV3PXcSEMTgBOhuaC1TrezbHsZRI3op_KBxtL0Hz7xm1nvHlR6tFhfk7Sm3TnO_Yi5mDtnhNNkF45oN11xqrVrNK_rmH_Qurmmp0x0poes6eVspfqJcijknHM0hhdmmH4aBOQoxJyGmCjG_hBhWm14_Rq_DjP5Py28DFRAnINenZY_p79__if0JIvCYSw</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Fu, Xuhuai</creator><creator>Gao, Ke</creator><creator>Liu, Nanjing</creator><creator>Guo, Bianqin</creator><creator>He, Meng</creator><creator>Lai, Nianyu</creator><creator>Li, Xinyu</creator><creator>Ding, Shijia</creator><creator>He, Xiaoyan</creator><creator>Wu, Lixiang</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20240301</creationdate><title>Au/PANI@PtCu-based electrochemical immunosensor for ultrasensitive determination of pro-gastrin-releasing peptide</title><author>Fu, Xuhuai ; Gao, Ke ; Liu, Nanjing ; Guo, Bianqin ; He, Meng ; Lai, Nianyu ; Li, Xinyu ; Ding, Shijia ; He, Xiaoyan ; Wu, Lixiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-cca942c82c40e03bc3097b5a16548580ff9eed43db9efa8d0d1d91addc269fa93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Analytical Chemistry</topic><topic>Antibodies</topic><topic>Antibodies, Immobilized</topic><topic>Biosensing Techniques</topic><topic>Catalysis</topic><topic>Catalytic activity</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Gastrin-Releasing Peptide</topic><topic>Glassy carbon</topic><topic>Gold</topic><topic>Hydrogen Peroxide</topic><topic>Immunoassay</topic><topic>Immunosensors</topic><topic>Intermetallic compounds</topic><topic>Metal Nanoparticles</topic><topic>Microengineering</topic><topic>Multi wall carbon nanotubes</topic><topic>Nanochemistry</topic><topic>Nanocomposites</topic><topic>Nanospheres</topic><topic>Nanotechnology</topic><topic>Nanotubes, Carbon</topic><topic>Original Paper</topic><topic>Polyanilines</topic><topic>Reduction</topic><topic>Synergistic effect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Xuhuai</creatorcontrib><creatorcontrib>Gao, Ke</creatorcontrib><creatorcontrib>Liu, Nanjing</creatorcontrib><creatorcontrib>Guo, Bianqin</creatorcontrib><creatorcontrib>He, Meng</creatorcontrib><creatorcontrib>Lai, Nianyu</creatorcontrib><creatorcontrib>Li, Xinyu</creatorcontrib><creatorcontrib>Ding, Shijia</creatorcontrib><creatorcontrib>He, Xiaoyan</creatorcontrib><creatorcontrib>Wu, Lixiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Mikrochimica acta (1966)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Xuhuai</au><au>Gao, Ke</au><au>Liu, Nanjing</au><au>Guo, Bianqin</au><au>He, Meng</au><au>Lai, Nianyu</au><au>Li, Xinyu</au><au>Ding, Shijia</au><au>He, Xiaoyan</au><au>Wu, Lixiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Au/PANI@PtCu-based electrochemical immunosensor for ultrasensitive determination of pro-gastrin-releasing peptide</atitle><jtitle>Mikrochimica acta (1966)</jtitle><stitle>Microchim Acta</stitle><addtitle>Mikrochim Acta</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>191</volume><issue>3</issue><spage>126</spage><epage>126</epage><pages>126-126</pages><artnum>126</artnum><issn>0026-3672</issn><eissn>1436-5073</eissn><abstract>An ultrasensitive sandwich-type electrochemical immunosensor for pro-gastrin-releasing peptide (ProGRP) detection was constructed based on PtCu nanodendrites functionalized Au/polyaniline nanospheres (Au/PANI@PtCu). The prepared Au/PANI@PtCu nanocomposites not only possessed excellent electro-catalytic activity of H
2
O
2
reduction due to the synergistic effect between the Au/PANI and PtCu NDs but also provided large specific surface area for detection of antibodies (Ab
2
) immobilization. In addition, Au nanoparticles encapsulated multi-wall carbon nanotubes (AuNPs@MWCNTs) were also applied to modify the glassy carbon electrode interface for loading numerous capture antibodies (Ab
1
). In the presence of target ProGRP, a sandwich-type electrochemical immunosensor showed a strong current response from the electro-catalysis of Au/PANI@PtCu toward H
2
O
2
reduction. Benefiting from the exceptional electro-catalytic performance of Au/PANI@PtCu and the high conductivity of AuNPs@MWCNTs, the sandwich-type immunoassay exhibited remarkable sensitivity in detection. The linear range extended from 100 fg/mL to 10 ng/mL, while achieving an impressively low limit of detection of 77.62 fg/mL.
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| ispartof | Mikrochimica acta (1966), 2024-03, Vol.191 (3), p.126-126, Article 126 |
| issn | 0026-3672 1436-5073 |
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| subjects | Analytical Chemistry Antibodies Antibodies, Immobilized Biosensing Techniques Catalysis Catalytic activity Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Gastrin-Releasing Peptide Glassy carbon Gold Hydrogen Peroxide Immunoassay Immunosensors Intermetallic compounds Metal Nanoparticles Microengineering Multi wall carbon nanotubes Nanochemistry Nanocomposites Nanospheres Nanotechnology Nanotubes, Carbon Original Paper Polyanilines Reduction Synergistic effect |
| title | Au/PANI@PtCu-based electrochemical immunosensor for ultrasensitive determination of pro-gastrin-releasing peptide |
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