Identifying the core residual symptom in patients with major depressive disorder using network analysis and illustrating its association with prognosis: A study based on the national cohorts in China
To identify the core residual symptom of MDD and assess its relationship with patients' long-term outcomes. All patients were administered antidepressants during the acute phase and treated continuously. The 521 patients remitted at month 6 of a multicenter prospective project were included. Re...
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| Veröffentlicht in: | General hospital psychiatry 2024-03, Vol.87, p.68-76 |
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| creator | Zhou, Jingjing Zhou, Jia Feng, Zizhao Feng, Lei Xiao, Le Chen, Xu Yang, Jian Feng, Yuan Wang, Gang |
| description | To identify the core residual symptom of MDD and assess its relationship with patients' long-term outcomes.
All patients were administered antidepressants during the acute phase and treated continuously. The 521 patients remitted at month 6 of a multicenter prospective project were included. Remission was defined as a Quick Inventory of Depressive Symptoms-Self-Report total score of ≤5. Functional impairments were measured with the Sheehan Disability Scale, quality of life with the Quality of Life Enjoyment and Satisfaction Questionnaire - short form, and family burden with the Family Burden Scale of Disease. Visits were scheduled at baseline, weeks 2, 8, 12, and month 6.
Difficulty with concentration/decision making was the core residual symptom of MDD, determined with the centrality measure of network analysis. It was positively associated with functional impairments and family burden (r = 0.35, P |
| doi_str_mv | 10.1016/j.genhosppsych.2024.01.012 |
| format | Article |
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All patients were administered antidepressants during the acute phase and treated continuously. The 521 patients remitted at month 6 of a multicenter prospective project were included. Remission was defined as a Quick Inventory of Depressive Symptoms-Self-Report total score of ≤5. Functional impairments were measured with the Sheehan Disability Scale, quality of life with the Quality of Life Enjoyment and Satisfaction Questionnaire - short form, and family burden with the Family Burden Scale of Disease. Visits were scheduled at baseline, weeks 2, 8, 12, and month 6.
Difficulty with concentration/decision making was the core residual symptom of MDD, determined with the centrality measure of network analysis. It was positively associated with functional impairments and family burden (r = 0.35, P < 0.01 and r = 0.31, P < 0.01, respectively) and negatively associated with life satisfaction (r = −0.29, P < 0.01). The exhibition of this residual symptom was associated with a family history of psychiatric disorders (OR = 2.610 [1.242–5.485]).
The core residual symptom of MDD, difficulty with concentration/decision making, is associated with poorer social functioning, heavier family burden, and lower life satisfaction. Early detection and intervention of this symptom may be beneficial.
Clinical trials registration number: (Chinese Clinical Trials.gov identifier) ChiCTR-OOC-17012566 and ChiCTR-INR-17012574.</description><identifier>ISSN: 0163-8343</identifier><identifier>EISSN: 1873-7714</identifier><identifier>DOI: 10.1016/j.genhosppsych.2024.01.012</identifier><identifier>PMID: 38325144</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Antidepressive Agents - therapeutic use ; Depression ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - drug therapy ; Depressive Disorder, Major - epidemiology ; Humans ; Network analysis ; Prospective Studies ; Quality of Life - psychology ; Residual symptom ; Self Report ; Social functioning</subject><ispartof>General hospital psychiatry, 2024-03, Vol.87, p.68-76</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-3486f65283633a9d93dba99a61539ae51da5ad7a62976b648394777d14fa6c6e3</citedby><cites>FETCH-LOGICAL-c380t-3486f65283633a9d93dba99a61539ae51da5ad7a62976b648394777d14fa6c6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.genhosppsych.2024.01.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38325144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Jingjing</creatorcontrib><creatorcontrib>Zhou, Jia</creatorcontrib><creatorcontrib>Feng, Zizhao</creatorcontrib><creatorcontrib>Feng, Lei</creatorcontrib><creatorcontrib>Xiao, Le</creatorcontrib><creatorcontrib>Chen, Xu</creatorcontrib><creatorcontrib>Yang, Jian</creatorcontrib><creatorcontrib>Feng, Yuan</creatorcontrib><creatorcontrib>Wang, Gang</creatorcontrib><title>Identifying the core residual symptom in patients with major depressive disorder using network analysis and illustrating its association with prognosis: A study based on the national cohorts in China</title><title>General hospital psychiatry</title><addtitle>Gen Hosp Psychiatry</addtitle><description>To identify the core residual symptom of MDD and assess its relationship with patients' long-term outcomes.
All patients were administered antidepressants during the acute phase and treated continuously. The 521 patients remitted at month 6 of a multicenter prospective project were included. Remission was defined as a Quick Inventory of Depressive Symptoms-Self-Report total score of ≤5. Functional impairments were measured with the Sheehan Disability Scale, quality of life with the Quality of Life Enjoyment and Satisfaction Questionnaire - short form, and family burden with the Family Burden Scale of Disease. Visits were scheduled at baseline, weeks 2, 8, 12, and month 6.
Difficulty with concentration/decision making was the core residual symptom of MDD, determined with the centrality measure of network analysis. It was positively associated with functional impairments and family burden (r = 0.35, P < 0.01 and r = 0.31, P < 0.01, respectively) and negatively associated with life satisfaction (r = −0.29, P < 0.01). The exhibition of this residual symptom was associated with a family history of psychiatric disorders (OR = 2.610 [1.242–5.485]).
The core residual symptom of MDD, difficulty with concentration/decision making, is associated with poorer social functioning, heavier family burden, and lower life satisfaction. Early detection and intervention of this symptom may be beneficial.
Clinical trials registration number: (Chinese Clinical Trials.gov identifier) ChiCTR-OOC-17012566 and ChiCTR-INR-17012574.</description><subject>Antidepressive Agents - therapeutic use</subject><subject>Depression</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Humans</subject><subject>Network analysis</subject><subject>Prospective Studies</subject><subject>Quality of Life - psychology</subject><subject>Residual symptom</subject><subject>Self Report</subject><subject>Social functioning</subject><issn>0163-8343</issn><issn>1873-7714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQxiMEokvhFZDFiUsWO87f3qoFSqVKXOBsee3ZjZfEDh6nVZ6Q12LSLYgj0kj2SL_55rO_LHsn-FZwUX84bY_g-4DThIvptwUvyi0XVMWzbCPaRuZNI8rn2YZgmbeylBfZK8QT57wqKvkyu5CtLCpRlpvs160Fn9xhcf7IUg_MhAgsAjo764HhMk4pjMx5NunkCEX24FLPRn0KkVmYCEV3D8w6DNFCZDOuUh7SQ4g_mPZ6WNAhXSxzwzBjiiREhCMpjRiMoz74s-wUw9EH4q_YNcM024XtNYJlBKzu_CNLxkzoQyQFMrbrndevsxcHPSC8eTovs--fP33bfcnvvt7c7q7vciNbnnJZtvWhropW1lLqznbS7nXX6VpUstNQCasrbRtdF11T7-uylV3ZNI0V5UHXpgZ5mb0_65LTnzNgUqNDA8OgPYQZVdEVsqOf5QWhV2fUxIAY4aCm6EYdFyW4WoNUJ_VvkGoNUnFBtQ6_fdoz70ewf0f_JEfAxzMA9Np7B1GhoXwMWBfBJGWD-589vwHUJLws</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Zhou, Jingjing</creator><creator>Zhou, Jia</creator><creator>Feng, Zizhao</creator><creator>Feng, Lei</creator><creator>Xiao, Le</creator><creator>Chen, Xu</creator><creator>Yang, Jian</creator><creator>Feng, Yuan</creator><creator>Wang, Gang</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202403</creationdate><title>Identifying the core residual symptom in patients with major depressive disorder using network analysis and illustrating its association with prognosis: A study based on the national cohorts in China</title><author>Zhou, Jingjing ; Zhou, Jia ; Feng, Zizhao ; Feng, Lei ; Xiao, Le ; Chen, Xu ; Yang, Jian ; Feng, Yuan ; Wang, Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-3486f65283633a9d93dba99a61539ae51da5ad7a62976b648394777d14fa6c6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antidepressive Agents - therapeutic use</topic><topic>Depression</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - drug therapy</topic><topic>Depressive Disorder, Major - epidemiology</topic><topic>Humans</topic><topic>Network analysis</topic><topic>Prospective Studies</topic><topic>Quality of Life - psychology</topic><topic>Residual symptom</topic><topic>Self Report</topic><topic>Social functioning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Jingjing</creatorcontrib><creatorcontrib>Zhou, Jia</creatorcontrib><creatorcontrib>Feng, Zizhao</creatorcontrib><creatorcontrib>Feng, Lei</creatorcontrib><creatorcontrib>Xiao, Le</creatorcontrib><creatorcontrib>Chen, Xu</creatorcontrib><creatorcontrib>Yang, Jian</creatorcontrib><creatorcontrib>Feng, Yuan</creatorcontrib><creatorcontrib>Wang, Gang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General hospital psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Jingjing</au><au>Zhou, Jia</au><au>Feng, Zizhao</au><au>Feng, Lei</au><au>Xiao, Le</au><au>Chen, Xu</au><au>Yang, Jian</au><au>Feng, Yuan</au><au>Wang, Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identifying the core residual symptom in patients with major depressive disorder using network analysis and illustrating its association with prognosis: A study based on the national cohorts in China</atitle><jtitle>General hospital psychiatry</jtitle><addtitle>Gen Hosp Psychiatry</addtitle><date>2024-03</date><risdate>2024</risdate><volume>87</volume><spage>68</spage><epage>76</epage><pages>68-76</pages><issn>0163-8343</issn><eissn>1873-7714</eissn><abstract>To identify the core residual symptom of MDD and assess its relationship with patients' long-term outcomes.
All patients were administered antidepressants during the acute phase and treated continuously. The 521 patients remitted at month 6 of a multicenter prospective project were included. Remission was defined as a Quick Inventory of Depressive Symptoms-Self-Report total score of ≤5. Functional impairments were measured with the Sheehan Disability Scale, quality of life with the Quality of Life Enjoyment and Satisfaction Questionnaire - short form, and family burden with the Family Burden Scale of Disease. Visits were scheduled at baseline, weeks 2, 8, 12, and month 6.
Difficulty with concentration/decision making was the core residual symptom of MDD, determined with the centrality measure of network analysis. It was positively associated with functional impairments and family burden (r = 0.35, P < 0.01 and r = 0.31, P < 0.01, respectively) and negatively associated with life satisfaction (r = −0.29, P < 0.01). The exhibition of this residual symptom was associated with a family history of psychiatric disorders (OR = 2.610 [1.242–5.485]).
The core residual symptom of MDD, difficulty with concentration/decision making, is associated with poorer social functioning, heavier family burden, and lower life satisfaction. Early detection and intervention of this symptom may be beneficial.
Clinical trials registration number: (Chinese Clinical Trials.gov identifier) ChiCTR-OOC-17012566 and ChiCTR-INR-17012574.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38325144</pmid><doi>10.1016/j.genhosppsych.2024.01.012</doi><tpages>9</tpages></addata></record> |
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| subjects | Antidepressive Agents - therapeutic use Depression Depressive Disorder, Major - diagnosis Depressive Disorder, Major - drug therapy Depressive Disorder, Major - epidemiology Humans Network analysis Prospective Studies Quality of Life - psychology Residual symptom Self Report Social functioning |
| title | Identifying the core residual symptom in patients with major depressive disorder using network analysis and illustrating its association with prognosis: A study based on the national cohorts in China |
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