Integrative multi-omics analyses reveal vesicle transport as a potential target for thoracic aortic aneurysm

Thoracic aortic aneurysm (TAA) refers to dilation and enlargement of the thoracic aorta caused by various reasons. Most patients have no apparent symptoms in the early stage and are subject to a poor prognosis once the aneurysm ruptures. It is crucial to identify individuals who are predisposed to T...

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Veröffentlicht in:	Computers in biology and medicine 2024-03, Vol.170, p.108071, Article 108071
Hauptverfasser:	Lei, Jiahao, Qiu, Peng, Wu, Zhaoyu, Ding, Angang, Hu, Jiateng, Hou, Jingli, Jiang, Yihong, Pu, Hongji, Huang, Qun, Zhang, Xing, Li, Bo, Wang, Xin, Ye, Kaichuang, Xu, Zhijue, Lu, Xinwu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Aortic Aneurysm, Thoracic - genetics Aortic Aneurysm, Thoracic - pathology Aortic aneurysms Chloroquine Chlorpromazine Coronary vessels Datasets Disease Disease Models, Animal Drug development Elastin Endocytosis Ethics Extracellular matrix Gene expression Genes Hospitals Humans Immune system Immunohistochemistry Lipids Metabolism Mice Multi-omics analysis Multiomics Proteins Proteomics Signal transduction Signs and symptoms Smooth muscle Survival Therapeutic targets Thoracic aortic aneurysm Thorax Transport processes Vesicular transport
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