Highly Sensitive Early Diagnosis of Kidney Damage Using Renal Clearable Zwitterion-Coated Ferrite Nanoprobe via Magnetic Resonance Imaging In Vivo
Iron oxide nanoprobes exhibit substantial potential in magnetic resonance imaging (MRI) of kidney diseases and can eliminate the nephrotoxicity of gadolinium-based contrast agents (GBCAs). Nevertheless, there is an extreme shortage of highly sensitive and renal clearable iron oxide nanoprobes suitab...
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| Veröffentlicht in: | Advanced healthcare materials 2024-05, Vol.13 (12), p.e2304577 |
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| creator | Zhou, Ting Dong, Yanzhi Wang, Xiaoyi Liu, Ruxia Cheng, Ran Pan, Jinbin Zhang, Xuejun Sun, Shao-Kai |
| description | Iron oxide nanoprobes exhibit substantial potential in magnetic resonance imaging (MRI) of kidney diseases and can eliminate the nephrotoxicity of gadolinium-based contrast agents (GBCAs). Nevertheless, there is an extreme shortage of highly sensitive and renal clearable iron oxide nanoprobes suitable for early kidney damage detection through MRI. Herein, a renal clearable ultra-small ferrite nanoprobe (UMFNPs@ZDS) is proposed for highly sensitive early diagnosis of kidney damage via structural and functional MRI in vivo for the first time. The nanoprobe comprises a ferrite core coated with a zwitterionic layer, and possesses a high T
relaxivity (12.52 mm
s
), a small hydrodynamic size (6.43 nm), remarkable water solubility, excellent biocompatibility, and impressive renal clearable ability. In a rat model of unilateral ureteral obstruction (UUO), the nanoprobe-based MRI can not only accurately visualize the locations of renal injury, but also provide comprehensive functional data including peak value, peak time, relative renal function (RRF), and clearance percentage via MRI. The findings prove the immense potential of ferrite nanoprobes as a superior alternative to GBCAs for the early diagnosis of kidney damage. |
| doi_str_mv | 10.1002/adhm.202304577 |
| format | Article |
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relaxivity (12.52 mm
s
), a small hydrodynamic size (6.43 nm), remarkable water solubility, excellent biocompatibility, and impressive renal clearable ability. In a rat model of unilateral ureteral obstruction (UUO), the nanoprobe-based MRI can not only accurately visualize the locations of renal injury, but also provide comprehensive functional data including peak value, peak time, relative renal function (RRF), and clearance percentage via MRI. The findings prove the immense potential of ferrite nanoprobes as a superior alternative to GBCAs for the early diagnosis of kidney damage.</description><identifier>ISSN: 2192-2640</identifier><identifier>ISSN: 2192-2659</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202304577</identifier><identifier>PMID: 38278515</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Animals ; Biocompatibility ; Contrast agents ; Contrast media ; Contrast Media - chemistry ; Damage detection ; Diagnosis ; Early Diagnosis ; Ferric Compounds - chemistry ; Ferrites ; Functional magnetic resonance imaging ; Gadolinium ; Iron oxides ; Kidney - diagnostic imaging ; Kidney - pathology ; Kidney diseases ; Kidney Diseases - diagnostic imaging ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medical imaging ; Rats ; Rats, Sprague-Dawley ; Renal function ; Structure-function relationships ; Zwitterions</subject><ispartof>Advanced healthcare materials, 2024-05, Vol.13 (12), p.e2304577</ispartof><rights>2024 Wiley‐VCH GmbH.</rights><rights>2024 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c278t-7d457804622136e05b53d5eb0be53f77a11650c7e8a1154f86c5835ec3504ebc3</cites><orcidid>0000-0001-6136-9969</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38278515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Ting</creatorcontrib><creatorcontrib>Dong, Yanzhi</creatorcontrib><creatorcontrib>Wang, Xiaoyi</creatorcontrib><creatorcontrib>Liu, Ruxia</creatorcontrib><creatorcontrib>Cheng, Ran</creatorcontrib><creatorcontrib>Pan, Jinbin</creatorcontrib><creatorcontrib>Zhang, Xuejun</creatorcontrib><creatorcontrib>Sun, Shao-Kai</creatorcontrib><title>Highly Sensitive Early Diagnosis of Kidney Damage Using Renal Clearable Zwitterion-Coated Ferrite Nanoprobe via Magnetic Resonance Imaging In Vivo</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>Iron oxide nanoprobes exhibit substantial potential in magnetic resonance imaging (MRI) of kidney diseases and can eliminate the nephrotoxicity of gadolinium-based contrast agents (GBCAs). Nevertheless, there is an extreme shortage of highly sensitive and renal clearable iron oxide nanoprobes suitable for early kidney damage detection through MRI. Herein, a renal clearable ultra-small ferrite nanoprobe (UMFNPs@ZDS) is proposed for highly sensitive early diagnosis of kidney damage via structural and functional MRI in vivo for the first time. The nanoprobe comprises a ferrite core coated with a zwitterionic layer, and possesses a high T
relaxivity (12.52 mm
s
), a small hydrodynamic size (6.43 nm), remarkable water solubility, excellent biocompatibility, and impressive renal clearable ability. In a rat model of unilateral ureteral obstruction (UUO), the nanoprobe-based MRI can not only accurately visualize the locations of renal injury, but also provide comprehensive functional data including peak value, peak time, relative renal function (RRF), and clearance percentage via MRI. The findings prove the immense potential of ferrite nanoprobes as a superior alternative to GBCAs for the early diagnosis of kidney damage.</description><subject>Animals</subject><subject>Biocompatibility</subject><subject>Contrast agents</subject><subject>Contrast media</subject><subject>Contrast Media - chemistry</subject><subject>Damage detection</subject><subject>Diagnosis</subject><subject>Early Diagnosis</subject><subject>Ferric Compounds - chemistry</subject><subject>Ferrites</subject><subject>Functional magnetic resonance imaging</subject><subject>Gadolinium</subject><subject>Iron oxides</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - pathology</subject><subject>Kidney diseases</subject><subject>Kidney Diseases - diagnostic imaging</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Renal function</subject><subject>Structure-function relationships</subject><subject>Zwitterions</subject><issn>2192-2640</issn><issn>2192-2659</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkb1OwzAURi0EAgRdGZElFpYU_8RJOqJSaEUBCSgDS-Q4N8EoscFOivoaPDGuCh3w4nut46NrfwidUDKkhLALWb61Q0YYJ7FI0x10yOiIRSwRo91tHZMDNPD-nYSVCJpkdB8d8IylmaDiEH1Pdf3WrPATGK87vQQ8kS70V1rWxnrtsa3wrS4NhDPZyhrwwmtT40cwssHjBqSTRQP49Ut3HThtTTS2soMSX4NzugN8L439cLYAvNQS3wUvdFoFgbdGGgV4FrRr5czgF720x2ivko2Hwe9-hBbXk-fxNJo_3MzGl_NIheG7KC3DozMSJ4xRngARheClgIIUIHiVppLSRBCVQhYqEVdZokTGBSguSAyF4kfofOMNw3324Lu81V5B00gDtvc5GzE-opTHIqBn_9B327vwAT7nRFBOEprxQA03lHLWewdV_uF0K90qpyRfB5avA8u3gYULp7_avmih3OJ_8fAfdD-Qvg</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Zhou, Ting</creator><creator>Dong, Yanzhi</creator><creator>Wang, Xiaoyi</creator><creator>Liu, Ruxia</creator><creator>Cheng, Ran</creator><creator>Pan, Jinbin</creator><creator>Zhang, Xuejun</creator><creator>Sun, Shao-Kai</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6136-9969</orcidid></search><sort><creationdate>20240501</creationdate><title>Highly Sensitive Early Diagnosis of Kidney Damage Using Renal Clearable Zwitterion-Coated Ferrite Nanoprobe via Magnetic Resonance Imaging In Vivo</title><author>Zhou, Ting ; Dong, Yanzhi ; Wang, Xiaoyi ; Liu, Ruxia ; Cheng, Ran ; Pan, Jinbin ; Zhang, Xuejun ; Sun, Shao-Kai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c278t-7d457804622136e05b53d5eb0be53f77a11650c7e8a1154f86c5835ec3504ebc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Biocompatibility</topic><topic>Contrast agents</topic><topic>Contrast media</topic><topic>Contrast Media - chemistry</topic><topic>Damage detection</topic><topic>Diagnosis</topic><topic>Early Diagnosis</topic><topic>Ferric Compounds - chemistry</topic><topic>Ferrites</topic><topic>Functional magnetic resonance imaging</topic><topic>Gadolinium</topic><topic>Iron oxides</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney - pathology</topic><topic>Kidney diseases</topic><topic>Kidney Diseases - diagnostic imaging</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Renal function</topic><topic>Structure-function relationships</topic><topic>Zwitterions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Ting</creatorcontrib><creatorcontrib>Dong, Yanzhi</creatorcontrib><creatorcontrib>Wang, Xiaoyi</creatorcontrib><creatorcontrib>Liu, Ruxia</creatorcontrib><creatorcontrib>Cheng, Ran</creatorcontrib><creatorcontrib>Pan, Jinbin</creatorcontrib><creatorcontrib>Zhang, Xuejun</creatorcontrib><creatorcontrib>Sun, Shao-Kai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Immunology Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced healthcare materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Ting</au><au>Dong, Yanzhi</au><au>Wang, Xiaoyi</au><au>Liu, Ruxia</au><au>Cheng, Ran</au><au>Pan, Jinbin</au><au>Zhang, Xuejun</au><au>Sun, Shao-Kai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly Sensitive Early Diagnosis of Kidney Damage Using Renal Clearable Zwitterion-Coated Ferrite Nanoprobe via Magnetic Resonance Imaging In Vivo</atitle><jtitle>Advanced healthcare materials</jtitle><addtitle>Adv Healthc Mater</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>13</volume><issue>12</issue><spage>e2304577</spage><pages>e2304577-</pages><issn>2192-2640</issn><issn>2192-2659</issn><eissn>2192-2659</eissn><abstract>Iron oxide nanoprobes exhibit substantial potential in magnetic resonance imaging (MRI) of kidney diseases and can eliminate the nephrotoxicity of gadolinium-based contrast agents (GBCAs). Nevertheless, there is an extreme shortage of highly sensitive and renal clearable iron oxide nanoprobes suitable for early kidney damage detection through MRI. Herein, a renal clearable ultra-small ferrite nanoprobe (UMFNPs@ZDS) is proposed for highly sensitive early diagnosis of kidney damage via structural and functional MRI in vivo for the first time. The nanoprobe comprises a ferrite core coated with a zwitterionic layer, and possesses a high T
relaxivity (12.52 mm
s
), a small hydrodynamic size (6.43 nm), remarkable water solubility, excellent biocompatibility, and impressive renal clearable ability. In a rat model of unilateral ureteral obstruction (UUO), the nanoprobe-based MRI can not only accurately visualize the locations of renal injury, but also provide comprehensive functional data including peak value, peak time, relative renal function (RRF), and clearance percentage via MRI. The findings prove the immense potential of ferrite nanoprobes as a superior alternative to GBCAs for the early diagnosis of kidney damage.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38278515</pmid><doi>10.1002/adhm.202304577</doi><orcidid>https://orcid.org/0000-0001-6136-9969</orcidid></addata></record> |
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| subjects | Animals Biocompatibility Contrast agents Contrast media Contrast Media - chemistry Damage detection Diagnosis Early Diagnosis Ferric Compounds - chemistry Ferrites Functional magnetic resonance imaging Gadolinium Iron oxides Kidney - diagnostic imaging Kidney - pathology Kidney diseases Kidney Diseases - diagnostic imaging Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical imaging Rats Rats, Sprague-Dawley Renal function Structure-function relationships Zwitterions |
| title | Highly Sensitive Early Diagnosis of Kidney Damage Using Renal Clearable Zwitterion-Coated Ferrite Nanoprobe via Magnetic Resonance Imaging In Vivo |
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