SWI/SNF chromatin remodeling complex in pancreatic ductal adenocarcinoma: Clinicopathologic and immunohistochemical study

The SWItch/Sucrose Non-Fermentable (SWI/SNF) complex is a multimeric protein involved in transcription regulation and DNA damage repair. SWI/SNF complex abnormalities are observed in approximately 14–34 % of pancreatic ductal adenocarcinomas (PDACs). Herein, we evaluated the immunohistochemical expr...

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Veröffentlicht in:	Human pathology 2024-02, Vol.144, p.40-45
Hauptverfasser:	Chen, Irene Y., Ettel, Mark G., Bell, Phoenix D., Huber, Aaron R., Findeis-Hosey, Jennifer J., Wang, Wenjia, Hezel, Aram F., Dunne, Richard F., Drage, Michael G., Agostini-Vulaj, Diana
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Carcinoma, Pancreatic Ductal - genetics Chromatin Assembly and Disassembly DNA Helicases Heterogeneity Humans Loss-of-function Nuclear Proteins Pancreatic ductal adenocarcinoma (PDAC) Pancreatic Neoplasms - genetics SMARC SWItch/Sucrose non-Fermentable complex (SWI/SNF) Transcription Factors
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