Activation of APE1 modulates Nrf2 protected against acute liver injury by inhibit hepatocyte ferroptosis and promote hepatocyte autophagy

•Decreased APE1 worsens acute liver injury.•LPS/GalN-induced acute liver injury exhibits both autophagy and ferroptosis.•Nrf2, a nuclear transcription factor, regulates both hepatocyte autophagy and ferroptosis.•APE1 activation regulates Nrf2, inhibiting hepatocyte ferroptosis and promotes hepatocyt...

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Veröffentlicht in:	International immunopharmacology 2024-02, Vol.128, p.111529-111529, Article 111529
Hauptverfasser:	Diao, Jianxin, Fan, Huijie, Zhang, Jia, Fu, Xiuqiong, Liao, Rongxin, Zhao, Peng, Huang, Wei, Huang, Shiying, Liao, Huajun, Yu, Jieying, Pan, Dongmei, Wang, Ming, Xiao, Wei, Wen, Xiaomin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute liver injury Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 Autophagy Ferroptosis Nuclear erythroid factor 2 like 2
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