Rap1GAP exacerbates myocardial infarction by regulating the AMPK/SIRT1/NF-κB signaling pathway

Rap1 GTPase-activating protein (Rap1GAP) is an important tumor suppressor. The purpose of this study was to investigate the role of Rap1GAP in myocardial infarction (MI) and its potential mechanism. Left anterior descending coronary artery ligation was performed on cardiac-specific Rap1GAP condition...

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Veröffentlicht in:	Cellular signalling 2024-05, Vol.117, p.111080-111080, Article 111080
Hauptverfasser:	Shan, Tiantian, Li, Xiaoying, Xie, Wenzhi, Wang, Shaoqin, Gao, Yan, Zheng, Yan, Su, Guohai, Li, Ying, Zhao, Zhuo
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism AMPK/SIRT1/NF-κB signaling pathway Animals Apoptosis Hypoxia - metabolism Inflammation Mice Myocardial infarction Myocardial Infarction - metabolism Myocytes, Cardiac - metabolism NF-kappa B - metabolism Oxidative stress Rap1GAP Rats Signal Transduction Sirtuin 1 - metabolism
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