Ultrasmall polyvinylpyrrolidone‐modified iridium nanoparticles with antioxidant and anti‐inflammatory activity for acute pancreatitis alleviation
Acute pancreatitis (AP) is a common and serious acute inflammatory disease with high severity rate and mortality. Inflammation and oxidative stress play an extremely important role in the development of AP disease. Polyvinylpyrrolidone‐modified iridium nanoparticles (IrNP‐PVP) have multienzyme mimet...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2024-07, Vol.112 (7), p.988-1003 |
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| creator | Jin, Wenzhang Xie, Xueting Shen, Shuqi Zhou, Xingjian Wang, Shunfu Zhang, Lijiang Su, Xiang |
| description | Acute pancreatitis (AP) is a common and serious acute inflammatory disease with high severity rate and mortality. Inflammation and oxidative stress play an extremely important role in the development of AP disease. Polyvinylpyrrolidone‐modified iridium nanoparticles (IrNP‐PVP) have multienzyme mimetic activity, and the aim of this article is to discuss the therapeutic alleviative effects of the ultrasmall nanozymes IrNP‐PVP on AP through their antioxidant and anti‐inflammatory effects. IrNP‐PVP were proved to inhibit inflammation and scavenge reactive oxygen species (ROS) at the cellular level. The synthetic IrNP‐PVP exhibit remarkable antioxidant and anti‐inflammatory activities in the prevention and treatment of AP mice by establishing murine AP model, which can reduce the oxidative stress and inflammatory response. The results of this article indicated that the ultrasmall nanozymes IrNP‐PVP effectively alleviate AP via scavenging ROS as well as suppressing inflammation both in vivo and in vitro, which might provide enormous promise for the AP management. |
| doi_str_mv | 10.1002/jbm.a.37679 |
| format | Article |
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Inflammation and oxidative stress play an extremely important role in the development of AP disease. Polyvinylpyrrolidone‐modified iridium nanoparticles (IrNP‐PVP) have multienzyme mimetic activity, and the aim of this article is to discuss the therapeutic alleviative effects of the ultrasmall nanozymes IrNP‐PVP on AP through their antioxidant and anti‐inflammatory effects. IrNP‐PVP were proved to inhibit inflammation and scavenge reactive oxygen species (ROS) at the cellular level. The synthetic IrNP‐PVP exhibit remarkable antioxidant and anti‐inflammatory activities in the prevention and treatment of AP mice by establishing murine AP model, which can reduce the oxidative stress and inflammatory response. The results of this article indicated that the ultrasmall nanozymes IrNP‐PVP effectively alleviate AP via scavenging ROS as well as suppressing inflammation both in vivo and in vitro, which might provide enormous promise for the AP management.</description><identifier>ISSN: 1549-3296</identifier><identifier>ISSN: 1552-4965</identifier><identifier>EISSN: 1552-4965</identifier><identifier>DOI: 10.1002/jbm.a.37679</identifier><identifier>PMID: 38318924</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Acute Disease ; acute pancreatitis ; Animals ; Anti-inflammatory agents ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Antioxidants ; Antioxidants - chemistry ; Antioxidants - pharmacology ; inflammation ; Inflammatory diseases ; Inflammatory response ; Iridium ; Iridium - chemistry ; Iridium - pharmacology ; iridium nanoparticles ; Male ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - therapeutic use ; Mice ; Nanoparticles ; Oxidative stress ; Oxidative Stress - drug effects ; Pancreatitis ; Pancreatitis - drug therapy ; Polyvinylpyrrolidone ; Povidone - chemistry ; Povidone - pharmacology ; RAW 264.7 Cells ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Scavenging</subject><ispartof>Journal of biomedical materials research. 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Part A</title><addtitle>J Biomed Mater Res A</addtitle><description>Acute pancreatitis (AP) is a common and serious acute inflammatory disease with high severity rate and mortality. Inflammation and oxidative stress play an extremely important role in the development of AP disease. Polyvinylpyrrolidone‐modified iridium nanoparticles (IrNP‐PVP) have multienzyme mimetic activity, and the aim of this article is to discuss the therapeutic alleviative effects of the ultrasmall nanozymes IrNP‐PVP on AP through their antioxidant and anti‐inflammatory effects. IrNP‐PVP were proved to inhibit inflammation and scavenge reactive oxygen species (ROS) at the cellular level. The synthetic IrNP‐PVP exhibit remarkable antioxidant and anti‐inflammatory activities in the prevention and treatment of AP mice by establishing murine AP model, which can reduce the oxidative stress and inflammatory response. The results of this article indicated that the ultrasmall nanozymes IrNP‐PVP effectively alleviate AP via scavenging ROS as well as suppressing inflammation both in vivo and in vitro, which might provide enormous promise for the AP management.</description><subject>Acute Disease</subject><subject>acute pancreatitis</subject><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antioxidants</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>inflammation</subject><subject>Inflammatory diseases</subject><subject>Inflammatory response</subject><subject>Iridium</subject><subject>Iridium - chemistry</subject><subject>Iridium - pharmacology</subject><subject>iridium nanoparticles</subject><subject>Male</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - therapeutic use</subject><subject>Mice</subject><subject>Nanoparticles</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pancreatitis</subject><subject>Pancreatitis - drug therapy</subject><subject>Polyvinylpyrrolidone</subject><subject>Povidone - chemistry</subject><subject>Povidone - pharmacology</subject><subject>RAW 264.7 Cells</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Scavenging</subject><issn>1549-3296</issn><issn>1552-4965</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhSMEoqWwYo8isUFCufg3N162Fb8qYkPX1iR2xFw5drCdW7LjEdjwgjwJvr2FBQtWZ470zdGMTlU9pWRDCWGvdv20gQ3ftlt1rzqlUrJGqFbeP8xCNZyp9qR6lNKuwC2R7GF1wjtOO8XEafXz2uUIaQLn6jm4dY9-dfMaY3Bogre_vv-YgsERrakxosFlqj34MEPMODib6hvMX2rwGcM3NEXLbG59WUU_OpgmyCGuNQwZ95jXegyxmCXbegY_RAsZM6a6nGD3WEzwj6sHI7hkn9zpWXX95vXny3fN1ae37y_Pr5qBS6kaIbgibMs6TspDsBWDgI5K2nfQQycGYltDBaeWGDFALywbxUhAkpaILTOKn1UvjrlzDF8Xm7KeMA3WOfA2LEkzxZiSlHBZ0Of_oLuwRF-u05yIAkkqDtTLIzXEkFK0o54jThBXTYk-tKVLWxr0bVuFfnaXufSTNX_ZP_UUgB2BG3R2_V-W_nDx8fyY-huWGqYE</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Jin, Wenzhang</creator><creator>Xie, Xueting</creator><creator>Shen, Shuqi</creator><creator>Zhou, Xingjian</creator><creator>Wang, Shunfu</creator><creator>Zhang, Lijiang</creator><creator>Su, Xiang</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3251-5792</orcidid></search><sort><creationdate>202407</creationdate><title>Ultrasmall polyvinylpyrrolidone‐modified iridium nanoparticles with antioxidant and anti‐inflammatory activity for acute pancreatitis alleviation</title><author>Jin, Wenzhang ; Xie, Xueting ; Shen, Shuqi ; Zhou, Xingjian ; Wang, Shunfu ; Zhang, Lijiang ; Su, Xiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3559-44390272830831a74c4a8151b8aba84c0e6d1431e0d4cab4e2f4f0a5060472d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acute Disease</topic><topic>acute pancreatitis</topic><topic>Animals</topic><topic>Anti-inflammatory agents</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antioxidants</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>inflammation</topic><topic>Inflammatory diseases</topic><topic>Inflammatory response</topic><topic>Iridium</topic><topic>Iridium - chemistry</topic><topic>Iridium - pharmacology</topic><topic>iridium nanoparticles</topic><topic>Male</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metal Nanoparticles - therapeutic use</topic><topic>Mice</topic><topic>Nanoparticles</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Pancreatitis</topic><topic>Pancreatitis - drug therapy</topic><topic>Polyvinylpyrrolidone</topic><topic>Povidone - chemistry</topic><topic>Povidone - pharmacology</topic><topic>RAW 264.7 Cells</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Scavenging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Wenzhang</creatorcontrib><creatorcontrib>Xie, Xueting</creatorcontrib><creatorcontrib>Shen, Shuqi</creatorcontrib><creatorcontrib>Zhou, Xingjian</creatorcontrib><creatorcontrib>Wang, Shunfu</creatorcontrib><creatorcontrib>Zhang, Lijiang</creatorcontrib><creatorcontrib>Su, Xiang</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Wenzhang</au><au>Xie, Xueting</au><au>Shen, Shuqi</au><au>Zhou, Xingjian</au><au>Wang, Shunfu</au><au>Zhang, Lijiang</au><au>Su, Xiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrasmall polyvinylpyrrolidone‐modified iridium nanoparticles with antioxidant and anti‐inflammatory activity for acute pancreatitis alleviation</atitle><jtitle>Journal of biomedical materials research. Part A</jtitle><addtitle>J Biomed Mater Res A</addtitle><date>2024-07</date><risdate>2024</risdate><volume>112</volume><issue>7</issue><spage>988</spage><epage>1003</epage><pages>988-1003</pages><issn>1549-3296</issn><issn>1552-4965</issn><eissn>1552-4965</eissn><abstract>Acute pancreatitis (AP) is a common and serious acute inflammatory disease with high severity rate and mortality. Inflammation and oxidative stress play an extremely important role in the development of AP disease. Polyvinylpyrrolidone‐modified iridium nanoparticles (IrNP‐PVP) have multienzyme mimetic activity, and the aim of this article is to discuss the therapeutic alleviative effects of the ultrasmall nanozymes IrNP‐PVP on AP through their antioxidant and anti‐inflammatory effects. IrNP‐PVP were proved to inhibit inflammation and scavenge reactive oxygen species (ROS) at the cellular level. The synthetic IrNP‐PVP exhibit remarkable antioxidant and anti‐inflammatory activities in the prevention and treatment of AP mice by establishing murine AP model, which can reduce the oxidative stress and inflammatory response. The results of this article indicated that the ultrasmall nanozymes IrNP‐PVP effectively alleviate AP via scavenging ROS as well as suppressing inflammation both in vivo and in vitro, which might provide enormous promise for the AP management.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>38318924</pmid><doi>10.1002/jbm.a.37679</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-3251-5792</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease acute pancreatitis Animals Anti-inflammatory agents Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antioxidants Antioxidants - chemistry Antioxidants - pharmacology inflammation Inflammatory diseases Inflammatory response Iridium Iridium - chemistry Iridium - pharmacology iridium nanoparticles Male Metal Nanoparticles - chemistry Metal Nanoparticles - therapeutic use Mice Nanoparticles Oxidative stress Oxidative Stress - drug effects Pancreatitis Pancreatitis - drug therapy Polyvinylpyrrolidone Povidone - chemistry Povidone - pharmacology RAW 264.7 Cells Reactive oxygen species Reactive Oxygen Species - metabolism Scavenging |
| title | Ultrasmall polyvinylpyrrolidone‐modified iridium nanoparticles with antioxidant and anti‐inflammatory activity for acute pancreatitis alleviation |
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