The impact of fullerenol nanoparticles on the growth of toxigenic Aspergillus flavus and aflatoxins production in vitro and in corn flour
Antifungal and antimycotoxigenic activity of fullerenol nanoparticles (FNPs) were investigated on Aspergillus flavus growth isolated from a real food sample and aflatoxins (AFs) (AFB1 and AFB2) production. The final FNPs concentrations in in vitro and in commercial corn flour after the stationary in...
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| Veröffentlicht in: | Journal of food science 2024-03, Vol.89 (3), p.1814-1827 |
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| creator | Živančev, Jelena Bulut, Sandra Kocić‐Tanackov, Sunčica Jović, Danica Fišteš, Aleksandar Antić, Igor Djordjevic, Aleksandar |
| description | Antifungal and antimycotoxigenic activity of fullerenol nanoparticles (FNPs) were investigated on Aspergillus flavus growth isolated from a real food sample and aflatoxins (AFs) (AFB1 and AFB2) production. The final FNPs concentrations in in vitro and in commercial corn flour after the stationary incubation period of 7 and 14 days were in the range 0.16–80 µg/mL and 0.16–80 µg/g, respectively. Nanocharacterization of FNPs revealed an average size of 5–20 nm and a zeta potential of −35 mV. The highest degree of A. flavus mycelium growth inhibition (28%) after 7 days was observed for applied FNP concentration of 8.0 µg/mL, while after 14 days FNP concentration of 0.32 µg/mL led to the maximal inhibition of A. flavus mycelium growth (36%). Spearman's correlations analysis revealed a strong positive correlation between AFB1 and AFB2 concentrations in YES broth after 7 (R = 0.994, p |
| doi_str_mv | 10.1111/1750-3841.16952 |
| format | Article |
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The final FNPs concentrations in in vitro and in commercial corn flour after the stationary incubation period of 7 and 14 days were in the range 0.16–80 µg/mL and 0.16–80 µg/g, respectively. Nanocharacterization of FNPs revealed an average size of 5–20 nm and a zeta potential of −35 mV. The highest degree of A. flavus mycelium growth inhibition (28%) after 7 days was observed for applied FNP concentration of 8.0 µg/mL, while after 14 days FNP concentration of 0.32 µg/mL led to the maximal inhibition of A. flavus mycelium growth (36%). Spearman's correlations analysis revealed a strong positive correlation between AFB1 and AFB2 concentrations in YES broth after 7 (R = 0.994, p < 0.05) and 14 days (R = 0.976), as well as between AFs concentrations and A. flavus mycelium mass after 7 (R = 0.786 for AFB1 and R = 0.766 for AFB2) and 14 days (R = 0.810 for AFB1 and R = 0.833 for AFB2). Paired samples t‐test showed the existence of a statistically significant difference (p < 0.05) between the produced AFs concentrations after the incubation of 7 and 14 days. Regarding the artificially inoculated corn flour the lower applied FNP concentrations (0.16–0.8 µg/g) achieved a reduction of AFB1 up to 42% and 60% after 7 and 14 days, respectively.</description><identifier>ISSN: 0022-1147</identifier><identifier>EISSN: 1750-3841</identifier><identifier>DOI: 10.1111/1750-3841.16952</identifier><identifier>PMID: 38317383</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Aflatoxins ; Aspergillus flavus ; Corn ; corn flour ; Cornflour ; Flour ; food safety ; food science ; fullerenol nanoparticles ; Fungicides ; growth retardation ; Incubation ; liquid chromatograph ; Mycelia ; mycelium ; nanomaterials ; Nanoparticles ; Statistical analysis ; t-test ; Zeta potential</subject><ispartof>Journal of food science, 2024-03, Vol.89 (3), p.1814-1827</ispartof><rights>2024 Institute of Food Technologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4052-79f2a7da19389612724b71524a3dfba38a727ee75135d9063a7e3cba00e74ff53</citedby><cites>FETCH-LOGICAL-c4052-79f2a7da19389612724b71524a3dfba38a727ee75135d9063a7e3cba00e74ff53</cites><orcidid>0000-0003-4240-3732</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1750-3841.16952$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1750-3841.16952$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1413,27906,27907,45556,45557</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38317383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Živančev, Jelena</creatorcontrib><creatorcontrib>Bulut, Sandra</creatorcontrib><creatorcontrib>Kocić‐Tanackov, Sunčica</creatorcontrib><creatorcontrib>Jović, Danica</creatorcontrib><creatorcontrib>Fišteš, Aleksandar</creatorcontrib><creatorcontrib>Antić, Igor</creatorcontrib><creatorcontrib>Djordjevic, Aleksandar</creatorcontrib><title>The impact of fullerenol nanoparticles on the growth of toxigenic Aspergillus flavus and aflatoxins production in vitro and in corn flour</title><title>Journal of food science</title><addtitle>J Food Sci</addtitle><description>Antifungal and antimycotoxigenic activity of fullerenol nanoparticles (FNPs) were investigated on Aspergillus flavus growth isolated from a real food sample and aflatoxins (AFs) (AFB1 and AFB2) production. The final FNPs concentrations in in vitro and in commercial corn flour after the stationary incubation period of 7 and 14 days were in the range 0.16–80 µg/mL and 0.16–80 µg/g, respectively. Nanocharacterization of FNPs revealed an average size of 5–20 nm and a zeta potential of −35 mV. The highest degree of A. flavus mycelium growth inhibition (28%) after 7 days was observed for applied FNP concentration of 8.0 µg/mL, while after 14 days FNP concentration of 0.32 µg/mL led to the maximal inhibition of A. flavus mycelium growth (36%). Spearman's correlations analysis revealed a strong positive correlation between AFB1 and AFB2 concentrations in YES broth after 7 (R = 0.994, p < 0.05) and 14 days (R = 0.976), as well as between AFs concentrations and A. flavus mycelium mass after 7 (R = 0.786 for AFB1 and R = 0.766 for AFB2) and 14 days (R = 0.810 for AFB1 and R = 0.833 for AFB2). Paired samples t‐test showed the existence of a statistically significant difference (p < 0.05) between the produced AFs concentrations after the incubation of 7 and 14 days. Regarding the artificially inoculated corn flour the lower applied FNP concentrations (0.16–0.8 µg/g) achieved a reduction of AFB1 up to 42% and 60% after 7 and 14 days, respectively.</description><subject>Aflatoxins</subject><subject>Aspergillus flavus</subject><subject>Corn</subject><subject>corn flour</subject><subject>Cornflour</subject><subject>Flour</subject><subject>food safety</subject><subject>food science</subject><subject>fullerenol nanoparticles</subject><subject>Fungicides</subject><subject>growth retardation</subject><subject>Incubation</subject><subject>liquid chromatograph</subject><subject>Mycelia</subject><subject>mycelium</subject><subject>nanomaterials</subject><subject>Nanoparticles</subject><subject>Statistical analysis</subject><subject>t-test</subject><subject>Zeta potential</subject><issn>0022-1147</issn><issn>1750-3841</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkU1PHSEUhknTRm-t6-4akm66GeWbYWls7UdMXGjXhMvAFcOFKcxo_Qn-axmvddGNLIBDnvOGkweAjxgd4baOseSooz3DR1goTt6A1cvLW7BCiJAOYyb3wftab9BSU7EH9mlPsWzbCjxcXTsYtqOxE8we-jlGV1zKESaT8mjKFGx0FeYEp0ZuSr6brhdyyn_DxqVg4UkdXdmEGOcKfTS37TBpgKbdFyhVOJY8zHYKLSQkeBumkp-QVthcUuvKc_kA3nkTqzt8Pg_A77NvV6c_uvOL7z9PT847yxAnnVSeGDkYrGivBCaSsLXEnDBDB782tDeSSOckx5QPCglqpKN2bRByknnP6QH4ssttv_ozuzrpbajWxWiSy3PVFHMqOOXsdZQoQhRTvRAN_fwfetNmSm2QRnEmlGx-GnW8o2zJtRbn9VjC1pR7jZFehOpFn1706SehrePTc-683rrhhf9nsAFiB9yF6O5fy9O_zr5e7pIfASNrq1o</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Živančev, Jelena</creator><creator>Bulut, Sandra</creator><creator>Kocić‐Tanackov, Sunčica</creator><creator>Jović, Danica</creator><creator>Fišteš, Aleksandar</creator><creator>Antić, Igor</creator><creator>Djordjevic, Aleksandar</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0003-4240-3732</orcidid></search><sort><creationdate>202403</creationdate><title>The impact of fullerenol nanoparticles on the growth of toxigenic Aspergillus flavus and aflatoxins production in vitro and in corn flour</title><author>Živančev, Jelena ; Bulut, Sandra ; Kocić‐Tanackov, Sunčica ; Jović, Danica ; Fišteš, Aleksandar ; Antić, Igor ; Djordjevic, Aleksandar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4052-79f2a7da19389612724b71524a3dfba38a727ee75135d9063a7e3cba00e74ff53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aflatoxins</topic><topic>Aspergillus flavus</topic><topic>Corn</topic><topic>corn flour</topic><topic>Cornflour</topic><topic>Flour</topic><topic>food safety</topic><topic>food science</topic><topic>fullerenol nanoparticles</topic><topic>Fungicides</topic><topic>growth retardation</topic><topic>Incubation</topic><topic>liquid chromatograph</topic><topic>Mycelia</topic><topic>mycelium</topic><topic>nanomaterials</topic><topic>Nanoparticles</topic><topic>Statistical analysis</topic><topic>t-test</topic><topic>Zeta potential</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Živančev, Jelena</creatorcontrib><creatorcontrib>Bulut, Sandra</creatorcontrib><creatorcontrib>Kocić‐Tanackov, Sunčica</creatorcontrib><creatorcontrib>Jović, Danica</creatorcontrib><creatorcontrib>Fišteš, Aleksandar</creatorcontrib><creatorcontrib>Antić, Igor</creatorcontrib><creatorcontrib>Djordjevic, Aleksandar</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Journal of food science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Živančev, Jelena</au><au>Bulut, Sandra</au><au>Kocić‐Tanackov, Sunčica</au><au>Jović, Danica</au><au>Fišteš, Aleksandar</au><au>Antić, Igor</au><au>Djordjevic, Aleksandar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of fullerenol nanoparticles on the growth of toxigenic Aspergillus flavus and aflatoxins production in vitro and in corn flour</atitle><jtitle>Journal of food science</jtitle><addtitle>J Food Sci</addtitle><date>2024-03</date><risdate>2024</risdate><volume>89</volume><issue>3</issue><spage>1814</spage><epage>1827</epage><pages>1814-1827</pages><issn>0022-1147</issn><eissn>1750-3841</eissn><abstract>Antifungal and antimycotoxigenic activity of fullerenol nanoparticles (FNPs) were investigated on Aspergillus flavus growth isolated from a real food sample and aflatoxins (AFs) (AFB1 and AFB2) production. The final FNPs concentrations in in vitro and in commercial corn flour after the stationary incubation period of 7 and 14 days were in the range 0.16–80 µg/mL and 0.16–80 µg/g, respectively. Nanocharacterization of FNPs revealed an average size of 5–20 nm and a zeta potential of −35 mV. The highest degree of A. flavus mycelium growth inhibition (28%) after 7 days was observed for applied FNP concentration of 8.0 µg/mL, while after 14 days FNP concentration of 0.32 µg/mL led to the maximal inhibition of A. flavus mycelium growth (36%). Spearman's correlations analysis revealed a strong positive correlation between AFB1 and AFB2 concentrations in YES broth after 7 (R = 0.994, p < 0.05) and 14 days (R = 0.976), as well as between AFs concentrations and A. flavus mycelium mass after 7 (R = 0.786 for AFB1 and R = 0.766 for AFB2) and 14 days (R = 0.810 for AFB1 and R = 0.833 for AFB2). Paired samples t‐test showed the existence of a statistically significant difference (p < 0.05) between the produced AFs concentrations after the incubation of 7 and 14 days. Regarding the artificially inoculated corn flour the lower applied FNP concentrations (0.16–0.8 µg/g) achieved a reduction of AFB1 up to 42% and 60% after 7 and 14 days, respectively.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38317383</pmid><doi>10.1111/1750-3841.16952</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-4240-3732</orcidid></addata></record> |
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| subjects | Aflatoxins Aspergillus flavus Corn corn flour Cornflour Flour food safety food science fullerenol nanoparticles Fungicides growth retardation Incubation liquid chromatograph Mycelia mycelium nanomaterials Nanoparticles Statistical analysis t-test Zeta potential |
| title | The impact of fullerenol nanoparticles on the growth of toxigenic Aspergillus flavus and aflatoxins production in vitro and in corn flour |
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