Enzyme-free sensitive SERS biosensor for the detection of thalassemia-associated microRNA-210 using a cascade dual-signal amplification strategy

β-thalassemia is a blood disorder caused by autosomal mutations. Gene modulation therapy to activate the γ-globin gene to induce fetal hemoglobin (HbF) synthesis has become a new option for the treatment of β-thalassemia. MicroRNA-210 (miR-210) contributes to studying the mechanism regulating γ-glob...

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Veröffentlicht in:	Analytica chimica acta 2024-03, Vol.1292, p.342255-342255, Article 342255
Hauptverfasser:	Chen, Qiying, Chen, Huagan, Kong, Hongxing, Chen, Ruijue, Gao, Si, Wang, Ying, Zhou, Pei, Huang, Wenyi, Cheng, Hao, Li, Lijun, Feng, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Thalassemia - diagnosis beta-Thalassemia - genetics Biosensing Techniques - methods Catalytic hairpin assembly reaction (CHA) DNA gamma-Globins Gold Humans Hybridization chain reaction (HCR) Limit of Detection Metal Nanoparticles MicroRNA-210 (miR-210) MicroRNAs Spectrum Analysis, Raman Surface-enhanced Raman scattering (SERS) β-thalassemia
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