Adsorption and controlled release of Chlortetracycline HCl by using multifunctional polymeric hydrogels
Adsorption and controlled release of Chlortetracycline HCl to and from multifunctional polymeric materials (HEMA/MAA) hydrogels were investigated. P(HEMA/MAA) hydrogels were synthesized by gamma radiation-induced copolymerization of 2-hydroxyethylmethacrylate (HEMA) and methacrylic acid (MAA) in aqu...
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| Veröffentlicht in: | European polymer journal 2007-02, Vol.43 (2), p.468-477 |
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| container_title | European polymer journal |
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| creator | Abou Taleb, Manal F. Abdel-Aal, Samia E. El-Kelesh, Nabil A. Hegazy, El-Sayed A. |
| description | Adsorption and controlled release of Chlortetracycline HCl to and from multifunctional polymeric materials (HEMA/MAA) hydrogels were investigated. P(HEMA/MAA) hydrogels were synthesized by gamma radiation-induced copolymerization of 2-hydroxyethylmethacrylate (HEMA) and methacrylic acid (MAA) in aqueous solution. The influence of copolymer composition and pH value of the surrounding medium on the type of water diffusion into the glassy polymer were discussed. Drug, Chlortetracycline HCl containing hydrogels, with different drug concentration to polymer ratios, was loaded by direct adsorption method. The influence of MAA content in the gel on the adsorption capacities of hydrogel was studied. Chlortetracycline HCl adsorption capacity of hydrogels was found to increase from 8 to 138
mg Chlortetracycline HCl per gram dry gel with increasing amount of MAA in the gel system and drug concentration. The effect of pH on the releasing behavior of Chlortetracycline HCl from gel matrix was investigated. In vitro drug release studies in different buffer solutions show that the basic parameters affecting the drug release behavior of hydrogel are the pH of the solution and MAA content of hydrogel. |
| doi_str_mv | 10.1016/j.eurpolymj.2006.11.001 |
| format | Article |
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mg Chlortetracycline HCl per gram dry gel with increasing amount of MAA in the gel system and drug concentration. The effect of pH on the releasing behavior of Chlortetracycline HCl from gel matrix was investigated. In vitro drug release studies in different buffer solutions show that the basic parameters affecting the drug release behavior of hydrogel are the pH of the solution and MAA content of hydrogel.</description><identifier>ISSN: 0014-3057</identifier><identifier>EISSN: 1873-1945</identifier><identifier>DOI: 10.1016/j.eurpolymj.2006.11.001</identifier><identifier>CODEN: EUPJAG</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Applied sciences ; Biological and medical sciences ; Chlortetracycline HCl ; Drug release ; Exact sciences and technology ; General pharmacology ; Hydrogel ; Medical sciences ; Methacrylic acid ; Organic polymers ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Physicochemistry of polymers ; Properties and characterization ; Radiation ; Solution and gel properties</subject><ispartof>European polymer journal, 2007-02, Vol.43 (2), p.468-477</ispartof><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-71260f2ff708292b5c235844a1fc6cb5a260660ee0a2cf17022a2480827848b93</citedby><cites>FETCH-LOGICAL-c407t-71260f2ff708292b5c235844a1fc6cb5a260660ee0a2cf17022a2480827848b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014305706003946$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18489018$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Abou Taleb, Manal F.</creatorcontrib><creatorcontrib>Abdel-Aal, Samia E.</creatorcontrib><creatorcontrib>El-Kelesh, Nabil A.</creatorcontrib><creatorcontrib>Hegazy, El-Sayed A.</creatorcontrib><title>Adsorption and controlled release of Chlortetracycline HCl by using multifunctional polymeric hydrogels</title><title>European polymer journal</title><description>Adsorption and controlled release of Chlortetracycline HCl to and from multifunctional polymeric materials (HEMA/MAA) hydrogels were investigated. P(HEMA/MAA) hydrogels were synthesized by gamma radiation-induced copolymerization of 2-hydroxyethylmethacrylate (HEMA) and methacrylic acid (MAA) in aqueous solution. The influence of copolymer composition and pH value of the surrounding medium on the type of water diffusion into the glassy polymer were discussed. Drug, Chlortetracycline HCl containing hydrogels, with different drug concentration to polymer ratios, was loaded by direct adsorption method. The influence of MAA content in the gel on the adsorption capacities of hydrogel was studied. Chlortetracycline HCl adsorption capacity of hydrogels was found to increase from 8 to 138
mg Chlortetracycline HCl per gram dry gel with increasing amount of MAA in the gel system and drug concentration. The effect of pH on the releasing behavior of Chlortetracycline HCl from gel matrix was investigated. In vitro drug release studies in different buffer solutions show that the basic parameters affecting the drug release behavior of hydrogel are the pH of the solution and MAA content of hydrogel.</description><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Chlortetracycline HCl</subject><subject>Drug release</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>Hydrogel</subject><subject>Medical sciences</subject><subject>Methacrylic acid</subject><subject>Organic polymers</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>Properties and characterization</subject><subject>Radiation</subject><subject>Solution and gel properties</subject><issn>0014-3057</issn><issn>1873-1945</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkU9vEzEQxS1EJULLZ8CXcttl7P3j3WMUAUWqxAXOljM7Th05dmrvIu23xyEVHHsaaeY3b0bvMfZRQC1A9J-PNS3pHP16OtYSoK-FqAHEG7YRg2oqMbbdW7YpnbZqoFPv2PucjwCgmr7ZsMN2yjGdZxcDN2HiGMOcovc08USeTCYeLd89-ZhmmpPBFb0LxB92nu9XvmQXDvy0-NnZJeBFxnj-9xtKDvnTOqV4IJ_v2I01PtOHl3rLfn398nP3UD3--PZ9t32ssAU1V0rIHqy0VsEgR7nvUDbd0LZGWOxx35ky7nsgAiPRCgVSGtkOBVZDO-zH5pZ9uuqeU3xeKM_65DKS9yZQXLIuomKAsX8VLL4p1bUXRXUFMcWcE1l9Tu5k0qoF6EsC-qj_JaAvCWghdPG7bN6_nDAZjbfJBHT5_3r5eAQxFG575YpP9NtR0hkdBaTJJcJZT9G9eusPQyGiDA</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Abou Taleb, Manal F.</creator><creator>Abdel-Aal, Samia E.</creator><creator>El-Kelesh, Nabil A.</creator><creator>Hegazy, El-Sayed A.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>JG9</scope></search><sort><creationdate>20070201</creationdate><title>Adsorption and controlled release of Chlortetracycline HCl by using multifunctional polymeric hydrogels</title><author>Abou Taleb, Manal F. ; Abdel-Aal, Samia E. ; El-Kelesh, Nabil A. ; Hegazy, El-Sayed A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-71260f2ff708292b5c235844a1fc6cb5a260660ee0a2cf17022a2480827848b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Chlortetracycline HCl</topic><topic>Drug release</topic><topic>Exact sciences and technology</topic><topic>General pharmacology</topic><topic>Hydrogel</topic><topic>Medical sciences</topic><topic>Methacrylic acid</topic><topic>Organic polymers</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>Properties and characterization</topic><topic>Radiation</topic><topic>Solution and gel properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abou Taleb, Manal F.</creatorcontrib><creatorcontrib>Abdel-Aal, Samia E.</creatorcontrib><creatorcontrib>El-Kelesh, Nabil A.</creatorcontrib><creatorcontrib>Hegazy, El-Sayed A.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Research Database</collection><jtitle>European polymer journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abou Taleb, Manal F.</au><au>Abdel-Aal, Samia E.</au><au>El-Kelesh, Nabil A.</au><au>Hegazy, El-Sayed A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adsorption and controlled release of Chlortetracycline HCl by using multifunctional polymeric hydrogels</atitle><jtitle>European polymer journal</jtitle><date>2007-02-01</date><risdate>2007</risdate><volume>43</volume><issue>2</issue><spage>468</spage><epage>477</epage><pages>468-477</pages><issn>0014-3057</issn><eissn>1873-1945</eissn><coden>EUPJAG</coden><abstract>Adsorption and controlled release of Chlortetracycline HCl to and from multifunctional polymeric materials (HEMA/MAA) hydrogels were investigated. P(HEMA/MAA) hydrogels were synthesized by gamma radiation-induced copolymerization of 2-hydroxyethylmethacrylate (HEMA) and methacrylic acid (MAA) in aqueous solution. The influence of copolymer composition and pH value of the surrounding medium on the type of water diffusion into the glassy polymer were discussed. Drug, Chlortetracycline HCl containing hydrogels, with different drug concentration to polymer ratios, was loaded by direct adsorption method. The influence of MAA content in the gel on the adsorption capacities of hydrogel was studied. Chlortetracycline HCl adsorption capacity of hydrogels was found to increase from 8 to 138
mg Chlortetracycline HCl per gram dry gel with increasing amount of MAA in the gel system and drug concentration. The effect of pH on the releasing behavior of Chlortetracycline HCl from gel matrix was investigated. In vitro drug release studies in different buffer solutions show that the basic parameters affecting the drug release behavior of hydrogel are the pH of the solution and MAA content of hydrogel.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.eurpolymj.2006.11.001</doi><tpages>10</tpages></addata></record> |
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| subjects | Applied sciences Biological and medical sciences Chlortetracycline HCl Drug release Exact sciences and technology General pharmacology Hydrogel Medical sciences Methacrylic acid Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Properties and characterization Radiation Solution and gel properties |
| title | Adsorption and controlled release of Chlortetracycline HCl by using multifunctional polymeric hydrogels |
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