The effect of human umbilical cord mesenchymal stem cells conditioned medium combined with tamoxifen drug on BRCA1 and BRCA2 expression in breast cancer mouse models

Background A growing number of studies has indicated that the expression of Breast Cancer Susceptibility Genes 1 ( BRCA1 ) and BRCA2 contribute to the resistance to DNA-damaging chemotherapies. Tamoxifen induces tumor cell death by suppressing estrogen receptor (ER) signaling and inducing DNA damage...

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Veröffentlicht in:	Molecular biology reports 2024-12, Vol.51 (1), p.241-241, Article 241
Hauptverfasser:	Panahandeh, Ahmad Reza, Delashoub, Masoud, Aval, Sedigheh Fekri
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animal Biochemistry Animal models Animals Biomedical and Life Sciences BRCA1 protein BRCA1 Protein - genetics BRCA2 protein BRCA2 Protein - genetics Breast cancer breast neoplasms Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cell death Chemoresistance Culture Media, Conditioned - pharmacology Disease Models, Animal DNA damage Down-regulation Estrogen receptors Female females Gene expression Histology Humans Life Sciences Mesenchymal Stem Cells Mice Morphology neoplasm cells Original Article Polymerase chain reaction RNA, Messenger Statistical analysis Stem cells Tamoxifen Tamoxifen - pharmacology therapeutics tumor suppressor proteins Tumors Umbilical cord
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