Cannabis containing THC impairs 20-min cycling time trial performance irrespective of the method of inhalation

Herein, we examine the human exercise response following cannabis inhalation, taking into consideration varied cannabinoid concentrations and different inhalation methods. A semirandomized crossover study design was used, with measures of perceived exertion and physiological responses to submaximal and maximal exercise. Participants ( = 14, 9 males 5 females) completed exercise after ) smoking Δ-9-tetrahydrocannabinol (THC)-predominant cannabis (S-THC), ) inhaling aerosol (vaporizing) from THC-predominant cannabis (V-THC), ) inhaling aerosol from cannabidiol (CBD)-predominant cannabis (V-CBD), or ) under control conditions. All exercise was performed on a cycle ergometer, with submaximal testing performed at 100 W followed by an evaluation of maximal exercise performance using an all-out 20-min time trial. Metabolism was characterized via the analysis of expired gases while subjective ratings of perceived exertion (RPE) were reported. During submaximal cycling, heart rate was higher during S-THC and V-THC compared with both control and V-CBD (all < 0.02). During maximal exercise, V̇e was lower in V-THC compared with control, S-THC, and V-CBD (all < 0.03), as was S-THC compared with control ( < 0.05). Both V̇o and RPE were similar between conditions during maximal exercise (both > 0.1). Mean power output during the 20-min time trial was significantly lower in the S-THC and V-THC conditions compared with both control and V-CBD (all < 0.04). Cannabis containing THC alters the physiological response to maximal and submaximal exercise, largely independent of the inhalation method. THC-containing cannabis negatively impacts vigorous exercise performance during a sustained 20-min effort, likely due to physiological and psychotropic effects. Inhalation of cannabis devoid of THC and primarily containing CBD has little physiological effect on the exercise response or performance. Inhalation of cannabis containing THC alters physiological responses to both submaximal and maximal exercise and reduces mean power output during a 20-min time trial, regardless of whether it is inhaled as smoke or aerosol. In contrast, cannabis devoid of THC and predominantly containing CBD has no effect on physiological responses to exercise or performance.