Riparin II-type benzamides as novel antibiofilm agents against dermatophytes: chemical synthesis, in vitro, ex vivo and in silico evaluation

Abstract Background The ability of dermatophytes to develop biofilms in host tissues confers physical and biochemical resistance to antifungal drugs. Therefore, research to find new compounds against dermatophyte biofilm is crucial. Objectives To evaluate the antifungal activity of riparin II (RIP2)...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2024-03, Vol.79 (3), p.617-631
Hauptverfasser:	Rocha, Marcelo Antônio Nóbrega da, Silva, Emanuel Pereira, Silva, Risley Nikael Medeiros, Sousa, Gabriela Ribeiro de, Barbosa-Filho, José Maria, Maia, Mayara dos Santos, Lima, Alberto Shellygton, de Souza-Ferrari, Jailton, Pereira, Fillipe de Oliveira
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - pharmacology Arthrodermataceae Benzamides - pharmacology Biofilms Humans Molecular Docking Simulation Tyramine - analogs & derivatives
Online-Zugang:	Volltext
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