Validating the safety of low-dose CTPA in pregnancy: results from the OPTICA (Optimised CT Pulmonary Angiography in Pregnancy) Study
Background Pulmonary embolism (PE) is a leading cause of pregnancy-related mortality. CT pulmonary angiogram (CTPA) is the first-line advanced imaging modality for suspected PE in pregnancy at institutes offering low-dose techniques; however, a protocol balancing safety with low dose remains undefin...
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| Veröffentlicht in: | European radiology 2024-08, Vol.34 (8), p.4864-4873 |
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| creator | Gillespie, Ciara D. Yates, Andrew Hughes, Mark Ewins, Karl McMahon, Gabriella Hynes, John Murphy, Mark C. Galligan, Marie Vencken, Sebastian Alih, Ekele Varden, John Donnelly, Jennifer Bolster, Ferdia Rowan, Michael Foley, Shane NíAinle, Fionnuala MacMahon, Peter J. |
| description | Background
Pulmonary embolism (PE) is a leading cause of pregnancy-related mortality. CT pulmonary angiogram (CTPA) is the first-line advanced imaging modality for suspected PE in pregnancy at institutes offering low-dose techniques; however, a protocol balancing safety with low dose remains undefined. The wide range of CTPA doses reported in pregnancy suggests a lack of confidence in implementing low-dose techniques in this group.
Purpose
To define and validate the safety, radiation dose and image quality of a low-dose CTPA protocol optimised for pregnancy.
Materials and methods
The OPTICA study is a prospective observational study. Pregnant study participants with suspected PE underwent the same CTPA protocol between May 2018 and February 2022. The primary outcome, CTPA safety, was judged by the reference standard; the 3-month incidence of venous thromboembolism (VTE) in study participants with a negative index CTPA. Secondary outcomes defined radiation dose and image quality. Absorbed breast, maternal effective and fetal doses were estimated by Monte-Carlo simulation on gestation-matched phantoms. Image quality was assessed by signal-to-noise and contrast-to-noise ratios and a Likert score for pulmonary arterial enhancement.
Results
A total of 116 CTPAs were performed in 113 pregnant women of which 16 CTPAs were excluded. PE was diagnosed on 1 CTPA and out-ruled in 99. The incidence of recurrent symptomatic VTE was 0.0% (one-sided 95% CI, 2.66%) at follow-up. The mean absorbed breast dose was 2.9 ± 2.1mGy, uterine/fetal dose was 0.1 ± 0.2mGy and maternal effective dose was 1.4 ± 0.9mSv. Signal-to-noise ratio (SNR) was 11.9 ± 3.7. Contrast-to-noise ratio (CNR) was 10.4 ± 3.5.
Conclusion
The OPTICA CTPA protocol safely excluded PE in pregnant women across all trimesters, with low fetal and maternal radiation.
Clinical relevance
OPTICA (Optimised CT Pulmonary Angiography in Pregnancy) is the first prospective study to define the achievable radiation dose, image-quality and safety of a low-dose CT pulmonary angiogram protocol optimised for pregnancy (NCT04179487). It provides the current benchmark for safe and achievable CT pulmonary angiogram doses in the pregnant population.
Key Points
• Despite the increased use of CT pulmonary angiogram in pregnancy, an optimised low-dose protocol has not been defined and reported doses in pregnancy continue to vary widely.
• The OPTICA (
Opti
mised
C
T Pulmonary
A
ngiography in Pregnancy) study prospectively defines th |
| doi_str_mv | 10.1007/s00330-024-10593-y |
| format | Article |
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Pulmonary embolism (PE) is a leading cause of pregnancy-related mortality. CT pulmonary angiogram (CTPA) is the first-line advanced imaging modality for suspected PE in pregnancy at institutes offering low-dose techniques; however, a protocol balancing safety with low dose remains undefined. The wide range of CTPA doses reported in pregnancy suggests a lack of confidence in implementing low-dose techniques in this group.
Purpose
To define and validate the safety, radiation dose and image quality of a low-dose CTPA protocol optimised for pregnancy.
Materials and methods
The OPTICA study is a prospective observational study. Pregnant study participants with suspected PE underwent the same CTPA protocol between May 2018 and February 2022. The primary outcome, CTPA safety, was judged by the reference standard; the 3-month incidence of venous thromboembolism (VTE) in study participants with a negative index CTPA. Secondary outcomes defined radiation dose and image quality. Absorbed breast, maternal effective and fetal doses were estimated by Monte-Carlo simulation on gestation-matched phantoms. Image quality was assessed by signal-to-noise and contrast-to-noise ratios and a Likert score for pulmonary arterial enhancement.
Results
A total of 116 CTPAs were performed in 113 pregnant women of which 16 CTPAs were excluded. PE was diagnosed on 1 CTPA and out-ruled in 99. The incidence of recurrent symptomatic VTE was 0.0% (one-sided 95% CI, 2.66%) at follow-up. The mean absorbed breast dose was 2.9 ± 2.1mGy, uterine/fetal dose was 0.1 ± 0.2mGy and maternal effective dose was 1.4 ± 0.9mSv. Signal-to-noise ratio (SNR) was 11.9 ± 3.7. Contrast-to-noise ratio (CNR) was 10.4 ± 3.5.
Conclusion
The OPTICA CTPA protocol safely excluded PE in pregnant women across all trimesters, with low fetal and maternal radiation.
Clinical relevance
OPTICA (Optimised CT Pulmonary Angiography in Pregnancy) is the first prospective study to define the achievable radiation dose, image-quality and safety of a low-dose CT pulmonary angiogram protocol optimised for pregnancy (NCT04179487). It provides the current benchmark for safe and achievable CT pulmonary angiogram doses in the pregnant population.
Key Points
• Despite the increased use of CT pulmonary angiogram in pregnancy, an optimised low-dose protocol has not been defined and reported doses in pregnancy continue to vary widely.
• The OPTICA (
Opti
mised
C
T Pulmonary
A
ngiography in Pregnancy) study prospectively defines the achievable dose, image quality and safety of a low-dose CT pulmonary angiogram protocol using widely available technology.
• OPTICA provides a benchmark for safe and achievable CT pulmonary angiogram doses in the pregnant population.</description><identifier>ISSN: 1432-1084</identifier><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-024-10593-y</identifier><identifier>PMID: 38296849</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Angiography ; Benchmarks ; Breast ; Chest ; Computed tomography ; Computed Tomography Angiography - methods ; Diagnostic Radiology ; Embolism ; Female ; Fetuses ; Humans ; Image contrast ; Image enhancement ; Image quality ; Imaging ; Internal Medicine ; Interventional Radiology ; Medical imaging ; Medicine ; Medicine & Public Health ; Monte Carlo simulation ; Neuroradiology ; Observational studies ; Pregnancy ; Pregnancy Complications, Cardiovascular - diagnostic imaging ; Prospective Studies ; Pulmonary Embolism - diagnostic imaging ; Pulmonary embolisms ; Radiation ; Radiation Dosage ; Radiology ; Safety ; Signal quality ; Signal to noise ratio ; Thromboembolism ; Ultrasound</subject><ispartof>European radiology, 2024-08, Vol.34 (8), p.4864-4873</ispartof><rights>The Author(s), under exclusive licence to European Society of Radiology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to European Society of Radiology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-656def1f40392d9dc23bdb706d39e570b8e7e2ac5e07b44f207f320ff39cb7413</cites><orcidid>0000-0002-3006-1467</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-024-10593-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-024-10593-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38296849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gillespie, Ciara D.</creatorcontrib><creatorcontrib>Yates, Andrew</creatorcontrib><creatorcontrib>Hughes, Mark</creatorcontrib><creatorcontrib>Ewins, Karl</creatorcontrib><creatorcontrib>McMahon, Gabriella</creatorcontrib><creatorcontrib>Hynes, John</creatorcontrib><creatorcontrib>Murphy, Mark C.</creatorcontrib><creatorcontrib>Galligan, Marie</creatorcontrib><creatorcontrib>Vencken, Sebastian</creatorcontrib><creatorcontrib>Alih, Ekele</creatorcontrib><creatorcontrib>Varden, John</creatorcontrib><creatorcontrib>Donnelly, Jennifer</creatorcontrib><creatorcontrib>Bolster, Ferdia</creatorcontrib><creatorcontrib>Rowan, Michael</creatorcontrib><creatorcontrib>Foley, Shane</creatorcontrib><creatorcontrib>NíAinle, Fionnuala</creatorcontrib><creatorcontrib>MacMahon, Peter J.</creatorcontrib><title>Validating the safety of low-dose CTPA in pregnancy: results from the OPTICA (Optimised CT Pulmonary Angiography in Pregnancy) Study</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Background
Pulmonary embolism (PE) is a leading cause of pregnancy-related mortality. CT pulmonary angiogram (CTPA) is the first-line advanced imaging modality for suspected PE in pregnancy at institutes offering low-dose techniques; however, a protocol balancing safety with low dose remains undefined. The wide range of CTPA doses reported in pregnancy suggests a lack of confidence in implementing low-dose techniques in this group.
Purpose
To define and validate the safety, radiation dose and image quality of a low-dose CTPA protocol optimised for pregnancy.
Materials and methods
The OPTICA study is a prospective observational study. Pregnant study participants with suspected PE underwent the same CTPA protocol between May 2018 and February 2022. The primary outcome, CTPA safety, was judged by the reference standard; the 3-month incidence of venous thromboembolism (VTE) in study participants with a negative index CTPA. Secondary outcomes defined radiation dose and image quality. Absorbed breast, maternal effective and fetal doses were estimated by Monte-Carlo simulation on gestation-matched phantoms. Image quality was assessed by signal-to-noise and contrast-to-noise ratios and a Likert score for pulmonary arterial enhancement.
Results
A total of 116 CTPAs were performed in 113 pregnant women of which 16 CTPAs were excluded. PE was diagnosed on 1 CTPA and out-ruled in 99. The incidence of recurrent symptomatic VTE was 0.0% (one-sided 95% CI, 2.66%) at follow-up. The mean absorbed breast dose was 2.9 ± 2.1mGy, uterine/fetal dose was 0.1 ± 0.2mGy and maternal effective dose was 1.4 ± 0.9mSv. Signal-to-noise ratio (SNR) was 11.9 ± 3.7. Contrast-to-noise ratio (CNR) was 10.4 ± 3.5.
Conclusion
The OPTICA CTPA protocol safely excluded PE in pregnant women across all trimesters, with low fetal and maternal radiation.
Clinical relevance
OPTICA (Optimised CT Pulmonary Angiography in Pregnancy) is the first prospective study to define the achievable radiation dose, image-quality and safety of a low-dose CT pulmonary angiogram protocol optimised for pregnancy (NCT04179487). It provides the current benchmark for safe and achievable CT pulmonary angiogram doses in the pregnant population.
Key Points
• Despite the increased use of CT pulmonary angiogram in pregnancy, an optimised low-dose protocol has not been defined and reported doses in pregnancy continue to vary widely.
• The OPTICA (
Opti
mised
C
T Pulmonary
A
ngiography in Pregnancy) study prospectively defines the achievable dose, image quality and safety of a low-dose CT pulmonary angiogram protocol using widely available technology.
• OPTICA provides a benchmark for safe and achievable CT pulmonary angiogram doses in the pregnant population.</description><subject>Adult</subject><subject>Angiography</subject><subject>Benchmarks</subject><subject>Breast</subject><subject>Chest</subject><subject>Computed tomography</subject><subject>Computed Tomography Angiography - methods</subject><subject>Diagnostic Radiology</subject><subject>Embolism</subject><subject>Female</subject><subject>Fetuses</subject><subject>Humans</subject><subject>Image contrast</subject><subject>Image enhancement</subject><subject>Image quality</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Monte Carlo simulation</subject><subject>Neuroradiology</subject><subject>Observational studies</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - diagnostic imaging</subject><subject>Prospective Studies</subject><subject>Pulmonary Embolism - diagnostic imaging</subject><subject>Pulmonary embolisms</subject><subject>Radiation</subject><subject>Radiation Dosage</subject><subject>Radiology</subject><subject>Safety</subject><subject>Signal quality</subject><subject>Signal to noise ratio</subject><subject>Thromboembolism</subject><subject>Ultrasound</subject><issn>1432-1084</issn><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1DAYhS0Eohd4ARbIEpt2kfL7MknMbjSigFRpRmJgayXx7zRVYgc7UZU9D16300LFgpVt-TufL4eQdwwuGEDxMQIIARlwmTFYKZEtL8gxk4KnZSlfPpsfkZMYbwBAMVm8Jkei5CovpTomv39WfWeqqXMtna6RxsritFBvae9vM-Mj0s1-t6ado2PA1lWuWT7RgHHup0ht8MNDbLvbf9us6dl2nLqhi2hSiu7mfvCuCgtdu7bzbajG6-XetHsyndPv02yWN-SVrfqIbx_HU_Lj8vN-8zW72n5J2qusETyfsnyVG7TMShCKG2UaLmpTF5AboXBVQF1igbxqVghFLaXlUFjBwVqhmrqQTJySs4N3DP7XjHHS6a4N9n3l0M9Rc8UZSz-UQ0I__IPe-Dm4dDstoGRKgZI8UfxANcHHGNDqMXRDerFmoO870oeOdOpIP3SklxR6_6ie6wHNn8hTKQkQByCmLddi-Hv2f7R3XiCcjg</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Gillespie, Ciara D.</creator><creator>Yates, Andrew</creator><creator>Hughes, Mark</creator><creator>Ewins, Karl</creator><creator>McMahon, Gabriella</creator><creator>Hynes, John</creator><creator>Murphy, Mark C.</creator><creator>Galligan, Marie</creator><creator>Vencken, Sebastian</creator><creator>Alih, Ekele</creator><creator>Varden, John</creator><creator>Donnelly, Jennifer</creator><creator>Bolster, Ferdia</creator><creator>Rowan, Michael</creator><creator>Foley, Shane</creator><creator>NíAinle, Fionnuala</creator><creator>MacMahon, Peter J.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3006-1467</orcidid></search><sort><creationdate>202408</creationdate><title>Validating the safety of low-dose CTPA in pregnancy: results from the OPTICA (Optimised CT Pulmonary Angiography in Pregnancy) Study</title><author>Gillespie, Ciara D. ; Yates, Andrew ; Hughes, Mark ; Ewins, Karl ; McMahon, Gabriella ; Hynes, John ; Murphy, Mark C. ; Galligan, Marie ; Vencken, Sebastian ; Alih, Ekele ; Varden, John ; Donnelly, Jennifer ; Bolster, Ferdia ; Rowan, Michael ; Foley, Shane ; NíAinle, Fionnuala ; MacMahon, Peter J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-656def1f40392d9dc23bdb706d39e570b8e7e2ac5e07b44f207f320ff39cb7413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Angiography</topic><topic>Benchmarks</topic><topic>Breast</topic><topic>Chest</topic><topic>Computed tomography</topic><topic>Computed Tomography Angiography - methods</topic><topic>Diagnostic Radiology</topic><topic>Embolism</topic><topic>Female</topic><topic>Fetuses</topic><topic>Humans</topic><topic>Image contrast</topic><topic>Image enhancement</topic><topic>Image quality</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Monte Carlo simulation</topic><topic>Neuroradiology</topic><topic>Observational studies</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular - diagnostic imaging</topic><topic>Prospective Studies</topic><topic>Pulmonary Embolism - diagnostic imaging</topic><topic>Pulmonary embolisms</topic><topic>Radiation</topic><topic>Radiation Dosage</topic><topic>Radiology</topic><topic>Safety</topic><topic>Signal quality</topic><topic>Signal to noise ratio</topic><topic>Thromboembolism</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gillespie, Ciara D.</creatorcontrib><creatorcontrib>Yates, Andrew</creatorcontrib><creatorcontrib>Hughes, Mark</creatorcontrib><creatorcontrib>Ewins, Karl</creatorcontrib><creatorcontrib>McMahon, Gabriella</creatorcontrib><creatorcontrib>Hynes, John</creatorcontrib><creatorcontrib>Murphy, Mark C.</creatorcontrib><creatorcontrib>Galligan, Marie</creatorcontrib><creatorcontrib>Vencken, Sebastian</creatorcontrib><creatorcontrib>Alih, Ekele</creatorcontrib><creatorcontrib>Varden, John</creatorcontrib><creatorcontrib>Donnelly, Jennifer</creatorcontrib><creatorcontrib>Bolster, Ferdia</creatorcontrib><creatorcontrib>Rowan, Michael</creatorcontrib><creatorcontrib>Foley, Shane</creatorcontrib><creatorcontrib>NíAinle, Fionnuala</creatorcontrib><creatorcontrib>MacMahon, Peter J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gillespie, Ciara D.</au><au>Yates, Andrew</au><au>Hughes, Mark</au><au>Ewins, Karl</au><au>McMahon, Gabriella</au><au>Hynes, John</au><au>Murphy, Mark C.</au><au>Galligan, Marie</au><au>Vencken, Sebastian</au><au>Alih, Ekele</au><au>Varden, John</au><au>Donnelly, Jennifer</au><au>Bolster, Ferdia</au><au>Rowan, Michael</au><au>Foley, Shane</au><au>NíAinle, Fionnuala</au><au>MacMahon, Peter J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validating the safety of low-dose CTPA in pregnancy: results from the OPTICA (Optimised CT Pulmonary Angiography in Pregnancy) Study</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2024-08</date><risdate>2024</risdate><volume>34</volume><issue>8</issue><spage>4864</spage><epage>4873</epage><pages>4864-4873</pages><issn>1432-1084</issn><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Background
Pulmonary embolism (PE) is a leading cause of pregnancy-related mortality. CT pulmonary angiogram (CTPA) is the first-line advanced imaging modality for suspected PE in pregnancy at institutes offering low-dose techniques; however, a protocol balancing safety with low dose remains undefined. The wide range of CTPA doses reported in pregnancy suggests a lack of confidence in implementing low-dose techniques in this group.
Purpose
To define and validate the safety, radiation dose and image quality of a low-dose CTPA protocol optimised for pregnancy.
Materials and methods
The OPTICA study is a prospective observational study. Pregnant study participants with suspected PE underwent the same CTPA protocol between May 2018 and February 2022. The primary outcome, CTPA safety, was judged by the reference standard; the 3-month incidence of venous thromboembolism (VTE) in study participants with a negative index CTPA. Secondary outcomes defined radiation dose and image quality. Absorbed breast, maternal effective and fetal doses were estimated by Monte-Carlo simulation on gestation-matched phantoms. Image quality was assessed by signal-to-noise and contrast-to-noise ratios and a Likert score for pulmonary arterial enhancement.
Results
A total of 116 CTPAs were performed in 113 pregnant women of which 16 CTPAs were excluded. PE was diagnosed on 1 CTPA and out-ruled in 99. The incidence of recurrent symptomatic VTE was 0.0% (one-sided 95% CI, 2.66%) at follow-up. The mean absorbed breast dose was 2.9 ± 2.1mGy, uterine/fetal dose was 0.1 ± 0.2mGy and maternal effective dose was 1.4 ± 0.9mSv. Signal-to-noise ratio (SNR) was 11.9 ± 3.7. Contrast-to-noise ratio (CNR) was 10.4 ± 3.5.
Conclusion
The OPTICA CTPA protocol safely excluded PE in pregnant women across all trimesters, with low fetal and maternal radiation.
Clinical relevance
OPTICA (Optimised CT Pulmonary Angiography in Pregnancy) is the first prospective study to define the achievable radiation dose, image-quality and safety of a low-dose CT pulmonary angiogram protocol optimised for pregnancy (NCT04179487). It provides the current benchmark for safe and achievable CT pulmonary angiogram doses in the pregnant population.
Key Points
• Despite the increased use of CT pulmonary angiogram in pregnancy, an optimised low-dose protocol has not been defined and reported doses in pregnancy continue to vary widely.
• The OPTICA (
Opti
mised
C
T Pulmonary
A
ngiography in Pregnancy) study prospectively defines the achievable dose, image quality and safety of a low-dose CT pulmonary angiogram protocol using widely available technology.
• OPTICA provides a benchmark for safe and achievable CT pulmonary angiogram doses in the pregnant population.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38296849</pmid><doi>10.1007/s00330-024-10593-y</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3006-1467</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-1084 |
| ispartof | European radiology, 2024-08, Vol.34 (8), p.4864-4873 |
| issn | 1432-1084 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2921114760 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Angiography Benchmarks Breast Chest Computed tomography Computed Tomography Angiography - methods Diagnostic Radiology Embolism Female Fetuses Humans Image contrast Image enhancement Image quality Imaging Internal Medicine Interventional Radiology Medical imaging Medicine Medicine & Public Health Monte Carlo simulation Neuroradiology Observational studies Pregnancy Pregnancy Complications, Cardiovascular - diagnostic imaging Prospective Studies Pulmonary Embolism - diagnostic imaging Pulmonary embolisms Radiation Radiation Dosage Radiology Safety Signal quality Signal to noise ratio Thromboembolism Ultrasound |
| title | Validating the safety of low-dose CTPA in pregnancy: results from the OPTICA (Optimised CT Pulmonary Angiography in Pregnancy) Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T05%3A20%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Validating%20the%20safety%20of%20low-dose%20CTPA%20in%20pregnancy:%20results%20from%20the%20OPTICA%20(Optimised%20CT%20Pulmonary%20Angiography%20in%20Pregnancy)%20Study&rft.jtitle=European%20radiology&rft.au=Gillespie,%20Ciara%20D.&rft.date=2024-08&rft.volume=34&rft.issue=8&rft.spage=4864&rft.epage=4873&rft.pages=4864-4873&rft.issn=1432-1084&rft.eissn=1432-1084&rft_id=info:doi/10.1007/s00330-024-10593-y&rft_dat=%3Cproquest_cross%3E2921114760%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3081990942&rft_id=info:pmid/38296849&rfr_iscdi=true |