Nanodrugs mediate TAMs-related arginine metabolism interference to boost photodynamic immunotherapy

As a potential treatment strategy for low immunogenic triple negative breast cancer (TNBC), photodynamic therapy (PDT) induced antitumor immunotherapy is greatly limited by the immunosuppressive tumor microenvironment (ITM), especially the M2 phenotype tumor-associated macrophages (TAMs). The balanc...

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Veröffentlicht in:	Journal of controlled release 2024-03, Vol.367, p.248-264
Hauptverfasser:	Chen, Yi, Shu, Xian, Guo, Jia-Yi, Xiang, Yun, Liang, Shi-Yu, Lai, Jin-Mei, Zhou, Jia-Yi, Liu, Li-Han, Wang, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine Arginine metabolism CD8-Positive T-Lymphocytes Cell Line, Tumor Humans Hyaluronic Acid Immunogenic cell death Immunosuppressive Agents Immunotherapy Nanoparticles Neoplasms Nitric Oxide Photodynamic therapy Triple Negative Breast Neoplasms - drug therapy Tumor Microenvironment Tumor-Associated Macrophages Tumor-associated macrophages reprogramming
Online-Zugang:	Volltext
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