Vasculitic neuropathy-related disability, pain, quality of life, and autonomic symptoms: a survey of 312 patients
To assess self-reported symptoms of neuropathy, disability, pain, health-related quality of life (HR-QOL) and autonomic dysfunction in patients with vasculitis. Patients with vasculitis (with or without neuropathy) were invited by Vasculitis UK to complete an anonymous online survey. Three hundred a...
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| Veröffentlicht in: | Rheumatology (Oxford, England) England), 2024-10, Vol.63 (10), p.2791-2798 |
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| creator | Collins, Michael P Hadden, Robert D M Luqmani, Raashid A |
| description | To assess self-reported symptoms of neuropathy, disability, pain, health-related quality of life (HR-QOL) and autonomic dysfunction in patients with vasculitis.
Patients with vasculitis (with or without neuropathy) were invited by Vasculitis UK to complete an anonymous online survey.
Three hundred and twelve patients (71% female) responded. Median age was 61-70 years. Median duration of vasculitis was 4 years (15 years). Vasculitic types included granulomatosis with polyangiitis (34%), unspecified ANCA-associated vasculitis (13%), microscopic polyangiitis (11%), eosinophilic granulomatosis with polyangiitis (11%), giant cell arteritis (10%), non-systemic vasculitic neuropathy (2%) and other (19%). Many patients reported foot/hand symptoms suggestive of neuropathy, including numbness (64%), pain (54%) or weakness (40%). Two hundred and forty-two patients (78%) met our definition of probable vasculitic neuropathy: diagnosis of neuropathy by vasculitis team OR numbness OR weakness in feet/hands. Only 52% had been formally diagnosed with neuropathy. Compared with 70 patients without neuropathy, neuropathy patients had greater disability measured by the inflammatory Rasch-built Overall Disability Scale (centile mean 63.1 [s.d. 17.3] vs 75.2 [16.7]; P |
| doi_str_mv | 10.1093/rheumatology/keae038 |
| format | Article |
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Patients with vasculitis (with or without neuropathy) were invited by Vasculitis UK to complete an anonymous online survey.
Three hundred and twelve patients (71% female) responded. Median age was 61-70 years. Median duration of vasculitis was 4 years (<2 months to >15 years). Vasculitic types included granulomatosis with polyangiitis (34%), unspecified ANCA-associated vasculitis (13%), microscopic polyangiitis (11%), eosinophilic granulomatosis with polyangiitis (11%), giant cell arteritis (10%), non-systemic vasculitic neuropathy (2%) and other (19%). Many patients reported foot/hand symptoms suggestive of neuropathy, including numbness (64%), pain (54%) or weakness (40%). Two hundred and forty-two patients (78%) met our definition of probable vasculitic neuropathy: diagnosis of neuropathy by vasculitis team OR numbness OR weakness in feet/hands. Only 52% had been formally diagnosed with neuropathy. Compared with 70 patients without neuropathy, neuropathy patients had greater disability measured by the inflammatory Rasch-built Overall Disability Scale (centile mean 63.1 [s.d. 17.3] vs 75.2 [16.7]; P < 0.0001), Inflammatory Neuropathy Cause and Treatment scale (median 2 [interquartile range 1-4] vs 0.5 [0-2]; P < 0.0001) and modified Rankin scale (median 2 [interquartile range 1-3] vs 2 [1-2)]; P = 0.0002); greater pain on an 11-point rating scale (mean 4.6 [s.d. 2.6] vs 3.5 [2.8]; P = 0.0009); and poorer HR-QOL on the EQ5D-3L (summary index mean 0.58 [s.d. 0.29] vs 0.69 [0.28]; P < 0.0001). Two-thirds reported autonomic symptoms (not associated with neuropathy).
Neuropathy is common and associated with significant disability, pain and impaired HR-QOL in patients with systemic vasculitis.</description><identifier>ISSN: 1462-0324</identifier><identifier>ISSN: 1462-0332</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/keae038</identifier><identifier>PMID: 38291915</identifier><language>eng</language><publisher>England</publisher><subject>Aged ; Autonomic Nervous System Diseases - etiology ; Autonomic Nervous System Diseases - physiopathology ; Disability Evaluation ; Female ; Humans ; Male ; Microscopic Polyangiitis - complications ; Microscopic Polyangiitis - diagnosis ; Middle Aged ; Pain - etiology ; Peripheral Nervous System Diseases - diagnosis ; Peripheral Nervous System Diseases - etiology ; Quality of Life ; Surveys and Questionnaires ; United Kingdom ; Vasculitis - complications ; Vasculitis - physiopathology</subject><ispartof>Rheumatology (Oxford, England), 2024-10, Vol.63 (10), p.2791-2798</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c186t-a80bb32745ebf6cefb5b5aef19615b7641a9acaffbc59cf8f81d1382cdd5ae7f3</cites><orcidid>0000-0002-4446-5841 ; 0000-0002-9661-145X ; 0000-0002-9702-0256</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38291915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Collins, Michael P</creatorcontrib><creatorcontrib>Hadden, Robert D M</creatorcontrib><creatorcontrib>Luqmani, Raashid A</creatorcontrib><title>Vasculitic neuropathy-related disability, pain, quality of life, and autonomic symptoms: a survey of 312 patients</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>To assess self-reported symptoms of neuropathy, disability, pain, health-related quality of life (HR-QOL) and autonomic dysfunction in patients with vasculitis.
Patients with vasculitis (with or without neuropathy) were invited by Vasculitis UK to complete an anonymous online survey.
Three hundred and twelve patients (71% female) responded. Median age was 61-70 years. Median duration of vasculitis was 4 years (<2 months to >15 years). Vasculitic types included granulomatosis with polyangiitis (34%), unspecified ANCA-associated vasculitis (13%), microscopic polyangiitis (11%), eosinophilic granulomatosis with polyangiitis (11%), giant cell arteritis (10%), non-systemic vasculitic neuropathy (2%) and other (19%). Many patients reported foot/hand symptoms suggestive of neuropathy, including numbness (64%), pain (54%) or weakness (40%). Two hundred and forty-two patients (78%) met our definition of probable vasculitic neuropathy: diagnosis of neuropathy by vasculitis team OR numbness OR weakness in feet/hands. Only 52% had been formally diagnosed with neuropathy. Compared with 70 patients without neuropathy, neuropathy patients had greater disability measured by the inflammatory Rasch-built Overall Disability Scale (centile mean 63.1 [s.d. 17.3] vs 75.2 [16.7]; P < 0.0001), Inflammatory Neuropathy Cause and Treatment scale (median 2 [interquartile range 1-4] vs 0.5 [0-2]; P < 0.0001) and modified Rankin scale (median 2 [interquartile range 1-3] vs 2 [1-2)]; P = 0.0002); greater pain on an 11-point rating scale (mean 4.6 [s.d. 2.6] vs 3.5 [2.8]; P = 0.0009); and poorer HR-QOL on the EQ5D-3L (summary index mean 0.58 [s.d. 0.29] vs 0.69 [0.28]; P < 0.0001). Two-thirds reported autonomic symptoms (not associated with neuropathy).
Neuropathy is common and associated with significant disability, pain and impaired HR-QOL in patients with systemic vasculitis.</description><subject>Aged</subject><subject>Autonomic Nervous System Diseases - etiology</subject><subject>Autonomic Nervous System Diseases - physiopathology</subject><subject>Disability Evaluation</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Microscopic Polyangiitis - complications</subject><subject>Microscopic Polyangiitis - diagnosis</subject><subject>Middle Aged</subject><subject>Pain - etiology</subject><subject>Peripheral Nervous System Diseases - diagnosis</subject><subject>Peripheral Nervous System Diseases - etiology</subject><subject>Quality of Life</subject><subject>Surveys and Questionnaires</subject><subject>United Kingdom</subject><subject>Vasculitis - complications</subject><subject>Vasculitis - physiopathology</subject><issn>1462-0324</issn><issn>1462-0332</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtLxTAQhYMovv-BSJYubjWPtrd1J-ILBDfqtkzSiUbbpjcPof_eqldxNTPMOWeYj5Ajzk45q-WZf8XUQ3Sde5nO3hGQyWqD7PK8FBmTUmz-9SLfIXshvDHGCi6rbbIjK1Hzmhe7ZPUMQafORqvpgMm7EeLrlHnsIGJLWxtA2Xk9LegIdljQVYKvkTpDO2twQWFoKaToBtfPGWHqx-j6cE6BhuQ_8FspuZjt0eIQwwHZMtAFPFzXffJ0ffV4eZvdP9zcXV7cZ5pXZcygYkpJscwLVKbUaFShCkDD65IXalnmHGrQYIzSRa1NZSrezs8J3bazbGnkPjn5yR29WyUMselt0Nh1MKBLoRG1YMVS1Hk-S_MfqfYuBI-mGb3twU8NZ80X7OY_7GYNe7Ydry8k1WP7Z_qlKz8BzlKDOQ</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Collins, Michael P</creator><creator>Hadden, Robert D M</creator><creator>Luqmani, Raashid A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4446-5841</orcidid><orcidid>https://orcid.org/0000-0002-9661-145X</orcidid><orcidid>https://orcid.org/0000-0002-9702-0256</orcidid></search><sort><creationdate>20241001</creationdate><title>Vasculitic neuropathy-related disability, pain, quality of life, and autonomic symptoms: a survey of 312 patients</title><author>Collins, Michael P ; Hadden, Robert D M ; Luqmani, Raashid A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c186t-a80bb32745ebf6cefb5b5aef19615b7641a9acaffbc59cf8f81d1382cdd5ae7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Autonomic Nervous System Diseases - etiology</topic><topic>Autonomic Nervous System Diseases - physiopathology</topic><topic>Disability Evaluation</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Microscopic Polyangiitis - complications</topic><topic>Microscopic Polyangiitis - diagnosis</topic><topic>Middle Aged</topic><topic>Pain - etiology</topic><topic>Peripheral Nervous System Diseases - diagnosis</topic><topic>Peripheral Nervous System Diseases - etiology</topic><topic>Quality of Life</topic><topic>Surveys and Questionnaires</topic><topic>United Kingdom</topic><topic>Vasculitis - complications</topic><topic>Vasculitis - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Collins, Michael P</creatorcontrib><creatorcontrib>Hadden, Robert D M</creatorcontrib><creatorcontrib>Luqmani, Raashid A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Collins, Michael P</au><au>Hadden, Robert D M</au><au>Luqmani, Raashid A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vasculitic neuropathy-related disability, pain, quality of life, and autonomic symptoms: a survey of 312 patients</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>63</volume><issue>10</issue><spage>2791</spage><epage>2798</epage><pages>2791-2798</pages><issn>1462-0324</issn><issn>1462-0332</issn><eissn>1462-0332</eissn><abstract>To assess self-reported symptoms of neuropathy, disability, pain, health-related quality of life (HR-QOL) and autonomic dysfunction in patients with vasculitis.
Patients with vasculitis (with or without neuropathy) were invited by Vasculitis UK to complete an anonymous online survey.
Three hundred and twelve patients (71% female) responded. Median age was 61-70 years. Median duration of vasculitis was 4 years (<2 months to >15 years). Vasculitic types included granulomatosis with polyangiitis (34%), unspecified ANCA-associated vasculitis (13%), microscopic polyangiitis (11%), eosinophilic granulomatosis with polyangiitis (11%), giant cell arteritis (10%), non-systemic vasculitic neuropathy (2%) and other (19%). Many patients reported foot/hand symptoms suggestive of neuropathy, including numbness (64%), pain (54%) or weakness (40%). Two hundred and forty-two patients (78%) met our definition of probable vasculitic neuropathy: diagnosis of neuropathy by vasculitis team OR numbness OR weakness in feet/hands. Only 52% had been formally diagnosed with neuropathy. Compared with 70 patients without neuropathy, neuropathy patients had greater disability measured by the inflammatory Rasch-built Overall Disability Scale (centile mean 63.1 [s.d. 17.3] vs 75.2 [16.7]; P < 0.0001), Inflammatory Neuropathy Cause and Treatment scale (median 2 [interquartile range 1-4] vs 0.5 [0-2]; P < 0.0001) and modified Rankin scale (median 2 [interquartile range 1-3] vs 2 [1-2)]; P = 0.0002); greater pain on an 11-point rating scale (mean 4.6 [s.d. 2.6] vs 3.5 [2.8]; P = 0.0009); and poorer HR-QOL on the EQ5D-3L (summary index mean 0.58 [s.d. 0.29] vs 0.69 [0.28]; P < 0.0001). Two-thirds reported autonomic symptoms (not associated with neuropathy).
Neuropathy is common and associated with significant disability, pain and impaired HR-QOL in patients with systemic vasculitis.</abstract><cop>England</cop><pmid>38291915</pmid><doi>10.1093/rheumatology/keae038</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4446-5841</orcidid><orcidid>https://orcid.org/0000-0002-9661-145X</orcidid><orcidid>https://orcid.org/0000-0002-9702-0256</orcidid></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Aged Autonomic Nervous System Diseases - etiology Autonomic Nervous System Diseases - physiopathology Disability Evaluation Female Humans Male Microscopic Polyangiitis - complications Microscopic Polyangiitis - diagnosis Middle Aged Pain - etiology Peripheral Nervous System Diseases - diagnosis Peripheral Nervous System Diseases - etiology Quality of Life Surveys and Questionnaires United Kingdom Vasculitis - complications Vasculitis - physiopathology |
| title | Vasculitic neuropathy-related disability, pain, quality of life, and autonomic symptoms: a survey of 312 patients |
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