Reproductive risk factors across the female lifecourse and later metabolic health

Metabolic health is characterized by optimal blood glucose, lipids, cholesterol, blood pressure, and adiposity. Alterations in these characteristics may lead to the development of type 2 diabetes mellitus or dyslipidemia. Recent evidence suggests that female reproductive characteristics may be overl...

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Veröffentlicht in:Cell metabolism 2024-02, Vol.36 (2), p.240-262
Hauptverfasser: Nichols, Amy R., Chavarro, Jorge E., Oken, Emily
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container_title Cell metabolism
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creator Nichols, Amy R.
Chavarro, Jorge E.
Oken, Emily
description Metabolic health is characterized by optimal blood glucose, lipids, cholesterol, blood pressure, and adiposity. Alterations in these characteristics may lead to the development of type 2 diabetes mellitus or dyslipidemia. Recent evidence suggests that female reproductive characteristics may be overlooked as risk factors that contribute to later metabolic dysfunction. These reproductive traits include the age at menarche, menstrual irregularity, the development of polycystic ovary syndrome, gestational weight change, gestational dysglycemia and dyslipidemia, and the severity and timing of menopausal symptoms. These risk factors may themselves be markers of future dysfunction or may be explained by shared underlying etiologies that promote long-term disease development. Disentangling underlying relationships and identifying potentially modifiable characteristics have an important bearing on therapeutic lifestyle modifications that could ease long-term metabolic burden. Further research that better characterizes associations between reproductive characteristics and metabolic health, clarifies underlying etiologies, and identifies indicators for clinical application is warranted in the prevention and management of metabolic dysfunction. Female reproductive characteristics may be overlooked as contributors to lifecourse metabolic dysfunction. Whether these characteristics are markers of future dysfunction or share underlying etiologies, disentangling these relationships may provide direction for therapeutic lifestyle modifications that could improve long-term metabolic burden.
doi_str_mv 10.1016/j.cmet.2024.01.002
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Further research that better characterizes associations between reproductive characteristics and metabolic health, clarifies underlying etiologies, and identifies indicators for clinical application is warranted in the prevention and management of metabolic dysfunction. Female reproductive characteristics may be overlooked as contributors to lifecourse metabolic dysfunction. 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subjects diabetes
Diabetes Mellitus, Type 2 - complications
Dyslipidemias
Female
Humans
metabolic dysfunction
Obesity - complications
PCOS
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - drug therapy
pregnancy
Risk Factors
title Reproductive risk factors across the female lifecourse and later metabolic health
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