Factors associated with sensitisation to selected aero‐allergens in children and adolescents with asthma followed up at Laquintinie Hospital Douala, Cameroon
Introduction In spite of the substantial impact of pediatric asthma on healthcare resources, there is a notable dearth of research focusing on allergen sensitization specifically in children and adolescents with asthma in Cameroon, with existing studies primarily concentrating on adult populations....
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| Veröffentlicht in: | Pediatric pulmonology 2024-05, Vol.59 (5), p.1207-1216 |
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| creator | Eposse Ekoube, Charlotte Abba, Soumaiyatou Endale Mangamba, Mireille Mandeng Ma Linwa, Edgar Tchouamo Pokem, Annick Mbonjo Bitsie, Dora Disso Massako, Jeannette Heles Nsang, Emmanuel Ngo Linwa, Esther Eleonore Kedy Mangamba Koum, Daniele‐Christiane |
| description | Introduction
In spite of the substantial impact of pediatric asthma on healthcare resources, there is a notable dearth of research focusing on allergen sensitization specifically in children and adolescents with asthma in Cameroon, with existing studies primarily concentrating on adult populations. We, therefore, set out to determine factors associated with sensitization to selected aero‐allergens in children and adolescents with asthma followed up at Laquintinie Hospital Douala, Cameroon.
Methodology
We conducted a cross‐sectional analytical study on patients aged 2–17 years followed up for pediatric asthma at Laquintinie Hospital Douala for 8 months (January to August 2023). Skin prick tests were performed using selected standardized aeroallergens extracts. Factors associated with sensitization were determined using multivariable logistic regression analysis. The threshold for significance was set at p 5 years, chest tightness at rest, and a personal history of allergic rhinitis. |
| doi_str_mv | 10.1002/ppul.26883 |
| format | Article |
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In spite of the substantial impact of pediatric asthma on healthcare resources, there is a notable dearth of research focusing on allergen sensitization specifically in children and adolescents with asthma in Cameroon, with existing studies primarily concentrating on adult populations. We, therefore, set out to determine factors associated with sensitization to selected aero‐allergens in children and adolescents with asthma followed up at Laquintinie Hospital Douala, Cameroon.
Methodology
We conducted a cross‐sectional analytical study on patients aged 2–17 years followed up for pediatric asthma at Laquintinie Hospital Douala for 8 months (January to August 2023). Skin prick tests were performed using selected standardized aeroallergens extracts. Factors associated with sensitization were determined using multivariable logistic regression analysis. The threshold for significance was set at p < .05.
Results
In total, 126 children and adolescents with asthma were recruited, 50.79% of whom were male with an average age of 8.00 ± 3.99 years. Eight out of 10 patients (83.52%) were sensitized to common aero‐allergens (20.59% monosensitized and 79.41% polysensitized). The most common aero‐allergens found were the dust mites Dermatophagoïdes pteronyssinus (81.37%), Blomia tropicalis (67.64%) and Dermatophagoïdes farinae (52.94%) followed by Blatella species (25.49%). The factors independently associated with sensitization in our population were the personal history of allergic rhinitis in the patient [adjusted odds ratio, aOR: 4.07 (95% confidence interval, CI: 1.41–11.76), b = 0.54, p = .009], chest tightness at rest [aOR: 5.92 (95% CI: 1.08–32.38), b = 0.87, p = .040), and age above 5 years [aOR: 4.65 (95% CI: 1.47–14.69), b = 0.59, p = .009).
Conclusion
Sensitization to multiple aeroallergens is common in children and adolescents with asthma, especially for dust mites and cockroaches. Factors associated with sensitization are patients aged >5 years, chest tightness at rest, and a personal history of allergic rhinitis.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.26883</identifier><identifier>PMID: 38289059</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Allergens ; Allergens - immunology ; Allergies ; Animals ; Asthma ; Asthma - immunology ; Cameroon ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Hay fever ; Humans ; Male ; paediatric asthma ; Pediatrics ; prick test ; Rhinitis ; Skin Tests ; Teenagers</subject><ispartof>Pediatric pulmonology, 2024-05, Vol.59 (5), p.1207-1216</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3163-38d1871a396484f099da686c39350909efe5c687847e76bc035af8f3563871643</cites><orcidid>0000-0002-4058-3509</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.26883$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.26883$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38289059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eposse Ekoube, Charlotte</creatorcontrib><creatorcontrib>Abba, Soumaiyatou</creatorcontrib><creatorcontrib>Endale Mangamba, Mireille</creatorcontrib><creatorcontrib>Mandeng Ma Linwa, Edgar</creatorcontrib><creatorcontrib>Tchouamo Pokem, Annick</creatorcontrib><creatorcontrib>Mbonjo Bitsie, Dora</creatorcontrib><creatorcontrib>Disso Massako, Jeannette</creatorcontrib><creatorcontrib>Heles Nsang, Emmanuel</creatorcontrib><creatorcontrib>Ngo Linwa, Esther Eleonore</creatorcontrib><creatorcontrib>Kedy Mangamba Koum, Daniele‐Christiane</creatorcontrib><title>Factors associated with sensitisation to selected aero‐allergens in children and adolescents with asthma followed up at Laquintinie Hospital Douala, Cameroon</title><title>Pediatric pulmonology</title><addtitle>Pediatr Pulmonol</addtitle><description>Introduction
In spite of the substantial impact of pediatric asthma on healthcare resources, there is a notable dearth of research focusing on allergen sensitization specifically in children and adolescents with asthma in Cameroon, with existing studies primarily concentrating on adult populations. We, therefore, set out to determine factors associated with sensitization to selected aero‐allergens in children and adolescents with asthma followed up at Laquintinie Hospital Douala, Cameroon.
Methodology
We conducted a cross‐sectional analytical study on patients aged 2–17 years followed up for pediatric asthma at Laquintinie Hospital Douala for 8 months (January to August 2023). Skin prick tests were performed using selected standardized aeroallergens extracts. Factors associated with sensitization were determined using multivariable logistic regression analysis. The threshold for significance was set at p < .05.
Results
In total, 126 children and adolescents with asthma were recruited, 50.79% of whom were male with an average age of 8.00 ± 3.99 years. Eight out of 10 patients (83.52%) were sensitized to common aero‐allergens (20.59% monosensitized and 79.41% polysensitized). The most common aero‐allergens found were the dust mites Dermatophagoïdes pteronyssinus (81.37%), Blomia tropicalis (67.64%) and Dermatophagoïdes farinae (52.94%) followed by Blatella species (25.49%). The factors independently associated with sensitization in our population were the personal history of allergic rhinitis in the patient [adjusted odds ratio, aOR: 4.07 (95% confidence interval, CI: 1.41–11.76), b = 0.54, p = .009], chest tightness at rest [aOR: 5.92 (95% CI: 1.08–32.38), b = 0.87, p = .040), and age above 5 years [aOR: 4.65 (95% CI: 1.47–14.69), b = 0.59, p = .009).
Conclusion
Sensitization to multiple aeroallergens is common in children and adolescents with asthma, especially for dust mites and cockroaches. Factors associated with sensitization are patients aged >5 years, chest tightness at rest, and a personal history of allergic rhinitis.</description><subject>Adolescent</subject><subject>Allergens</subject><subject>Allergens - immunology</subject><subject>Allergies</subject><subject>Animals</subject><subject>Asthma</subject><subject>Asthma - immunology</subject><subject>Cameroon</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Hay fever</subject><subject>Humans</subject><subject>Male</subject><subject>paediatric asthma</subject><subject>Pediatrics</subject><subject>prick test</subject><subject>Rhinitis</subject><subject>Skin Tests</subject><subject>Teenagers</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFu1DAUhi0EokNhwwGQJTYIkWLHiWMv0UAp0kh0QdfRq_PCuHLs1HY06o4jcAPuxknwkMKCBStLfp8_v18_Ic85O-OM1W_neXFntVRKPCAbzrSuWKPlQ7JRXdtWUklxQp6kdMNYmWn-mJwIVSvNWr0hP87B5BAThZSCsZBxoAeb9zShTzbbBNkGT3MoFw7NcQwYw89v38E5jF8LRa2nZm_dENFT8AUYgsNk0Oe0uiDl_QR0DM6FQzEsM4VMd3C7WJ-tt0gvQpptBkffhwUcvKFbmMo3wT8lj0ZwCZ_dn6fk6vzDl-1Ftfv88dP23a4ygktRCTVw1XEQWjaqGUvOAUpwI7RomWYaR2yNVJ1qOuzktWGihVGNopWiPJONOCWvVu8cw-2CKfeTLRGcA49hSX2ta8aV7GpV0Jf_oDdhib5s1wvWdFq1mrFCvV4pE0NKEcd-jnaCeNdz1h9r64-19b9rK_CLe-VyPeHwF_3TUwH4Chysw7v_qPrLy6vdKv0FWCqlrQ</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Eposse Ekoube, Charlotte</creator><creator>Abba, Soumaiyatou</creator><creator>Endale Mangamba, Mireille</creator><creator>Mandeng Ma Linwa, Edgar</creator><creator>Tchouamo Pokem, Annick</creator><creator>Mbonjo Bitsie, Dora</creator><creator>Disso Massako, Jeannette</creator><creator>Heles Nsang, Emmanuel</creator><creator>Ngo Linwa, Esther Eleonore</creator><creator>Kedy Mangamba Koum, Daniele‐Christiane</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4058-3509</orcidid></search><sort><creationdate>202405</creationdate><title>Factors associated with sensitisation to selected aero‐allergens in children and adolescents with asthma followed up at Laquintinie Hospital Douala, Cameroon</title><author>Eposse Ekoube, Charlotte ; Abba, Soumaiyatou ; Endale Mangamba, Mireille ; Mandeng Ma Linwa, Edgar ; Tchouamo Pokem, Annick ; Mbonjo Bitsie, Dora ; Disso Massako, Jeannette ; Heles Nsang, Emmanuel ; Ngo Linwa, Esther Eleonore ; Kedy Mangamba Koum, Daniele‐Christiane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3163-38d1871a396484f099da686c39350909efe5c687847e76bc035af8f3563871643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Allergens</topic><topic>Allergens - immunology</topic><topic>Allergies</topic><topic>Animals</topic><topic>Asthma</topic><topic>Asthma - immunology</topic><topic>Cameroon</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Hay fever</topic><topic>Humans</topic><topic>Male</topic><topic>paediatric asthma</topic><topic>Pediatrics</topic><topic>prick test</topic><topic>Rhinitis</topic><topic>Skin Tests</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eposse Ekoube, Charlotte</creatorcontrib><creatorcontrib>Abba, Soumaiyatou</creatorcontrib><creatorcontrib>Endale Mangamba, Mireille</creatorcontrib><creatorcontrib>Mandeng Ma Linwa, Edgar</creatorcontrib><creatorcontrib>Tchouamo Pokem, Annick</creatorcontrib><creatorcontrib>Mbonjo Bitsie, Dora</creatorcontrib><creatorcontrib>Disso Massako, Jeannette</creatorcontrib><creatorcontrib>Heles Nsang, Emmanuel</creatorcontrib><creatorcontrib>Ngo Linwa, Esther Eleonore</creatorcontrib><creatorcontrib>Kedy Mangamba Koum, Daniele‐Christiane</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eposse Ekoube, Charlotte</au><au>Abba, Soumaiyatou</au><au>Endale Mangamba, Mireille</au><au>Mandeng Ma Linwa, Edgar</au><au>Tchouamo Pokem, Annick</au><au>Mbonjo Bitsie, Dora</au><au>Disso Massako, Jeannette</au><au>Heles Nsang, Emmanuel</au><au>Ngo Linwa, Esther Eleonore</au><au>Kedy Mangamba Koum, Daniele‐Christiane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with sensitisation to selected aero‐allergens in children and adolescents with asthma followed up at Laquintinie Hospital Douala, Cameroon</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr Pulmonol</addtitle><date>2024-05</date><risdate>2024</risdate><volume>59</volume><issue>5</issue><spage>1207</spage><epage>1216</epage><pages>1207-1216</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract>Introduction
In spite of the substantial impact of pediatric asthma on healthcare resources, there is a notable dearth of research focusing on allergen sensitization specifically in children and adolescents with asthma in Cameroon, with existing studies primarily concentrating on adult populations. We, therefore, set out to determine factors associated with sensitization to selected aero‐allergens in children and adolescents with asthma followed up at Laquintinie Hospital Douala, Cameroon.
Methodology
We conducted a cross‐sectional analytical study on patients aged 2–17 years followed up for pediatric asthma at Laquintinie Hospital Douala for 8 months (January to August 2023). Skin prick tests were performed using selected standardized aeroallergens extracts. Factors associated with sensitization were determined using multivariable logistic regression analysis. The threshold for significance was set at p < .05.
Results
In total, 126 children and adolescents with asthma were recruited, 50.79% of whom were male with an average age of 8.00 ± 3.99 years. Eight out of 10 patients (83.52%) were sensitized to common aero‐allergens (20.59% monosensitized and 79.41% polysensitized). The most common aero‐allergens found were the dust mites Dermatophagoïdes pteronyssinus (81.37%), Blomia tropicalis (67.64%) and Dermatophagoïdes farinae (52.94%) followed by Blatella species (25.49%). The factors independently associated with sensitization in our population were the personal history of allergic rhinitis in the patient [adjusted odds ratio, aOR: 4.07 (95% confidence interval, CI: 1.41–11.76), b = 0.54, p = .009], chest tightness at rest [aOR: 5.92 (95% CI: 1.08–32.38), b = 0.87, p = .040), and age above 5 years [aOR: 4.65 (95% CI: 1.47–14.69), b = 0.59, p = .009).
Conclusion
Sensitization to multiple aeroallergens is common in children and adolescents with asthma, especially for dust mites and cockroaches. Factors associated with sensitization are patients aged >5 years, chest tightness at rest, and a personal history of allergic rhinitis.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38289059</pmid><doi>10.1002/ppul.26883</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4058-3509</orcidid></addata></record> |
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| ispartof | Pediatric pulmonology, 2024-05, Vol.59 (5), p.1207-1216 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Allergens Allergens - immunology Allergies Animals Asthma Asthma - immunology Cameroon Child Child, Preschool Cross-Sectional Studies Female Hay fever Humans Male paediatric asthma Pediatrics prick test Rhinitis Skin Tests Teenagers |
| title | Factors associated with sensitisation to selected aero‐allergens in children and adolescents with asthma followed up at Laquintinie Hospital Douala, Cameroon |
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