The formation of an antibacterial agent–apatite composite coating on a polymer surface using a metastable calcium phosphate solution
A percutaneous device with antibacterial activity and good biocompatibility is desired for clinical applications. Three types of antibacterial agent: lactoferrin (LF), tetracycline (TC), and gatifloxacin (GFLX) were immobilized on the surface of an ethylene-vinyl alcohol copolymer (EVOH) using a liq...
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| Veröffentlicht in: | Biomaterials 2006-06, Vol.27 (17), p.3295-3303 |
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| creator | Oyane, Ayako Yokoyama, Yoshiro Uchida, Masaki Ito, Atsuo |
| description | A percutaneous device with antibacterial activity and good biocompatibility is desired for clinical applications. Three types of antibacterial agent: lactoferrin (LF), tetracycline (TC), and gatifloxacin (GFLX) were immobilized on the surface of an ethylene-vinyl alcohol copolymer (EVOH) using a liquid phase coating process. In this process, an EVOH plate was alternately dipped in calcium and phosphate ion solutions, and then immersed in a metastable calcium phosphate solution supplemented with 4, 40, or 400
μg/mL of the antibacterial agent. As a result, the antibacterial agent was immobilized on the EVOH surface in the form of an antibacterial agent–apatite composite layer. The amount of immobilized antibacterial agent increased with increasing absorption affinity for apatite in the order: GFLX |
| doi_str_mv | 10.1016/j.biomaterials.2006.01.029 |
| format | Article |
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μg/mL of the antibacterial agent. As a result, the antibacterial agent was immobilized on the EVOH surface in the form of an antibacterial agent–apatite composite layer. The amount of immobilized antibacterial agent increased with increasing absorption affinity for apatite in the order: GFLX<TC<LF. On the other hand, the release rate of the antibacterial agent from the composite was ordered in the opposite sense; i.e., LF<TC<GFLX. The composites investigated in this study showed antibacterial activity against
Escherichia coli and
Staphylococcus aureus, and would be useful as materials in percutaneous devices having antibacterial activity and good biocompatibility.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2006.01.029</identifier><identifier>PMID: 16487584</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibacterial agent ; Apatite ; Apatites - chemistry ; Biocompatible Materials - chemistry ; Bone Substitutes ; Calcium - chemistry ; Calcium Compounds - chemistry ; Calcium Phosphates - chemistry ; Dose-Response Relationship, Drug ; Escherichia coli ; Escherichia coli - metabolism ; Fluoroquinolones - chemistry ; Gatifloxacin (GFLX) ; Ions ; Kinetics ; Lactoferrin (LF) ; Lactoferrin - chemistry ; Materials Testing ; Microscopy, Electron, Scanning ; Percutaneous device ; Phosphates - chemistry ; Polymers - chemistry ; Solutions ; Spectrometry, X-Ray Emission ; Staphylococcus aureus ; Staphylococcus aureus - metabolism ; Tetracycline (TC) ; Tetracycline - chemistry ; Time Factors</subject><ispartof>Biomaterials, 2006-06, Vol.27 (17), p.3295-3303</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-3f4b0eca22c1e55c7a2f3cd0d3b859d419de9608a7900f6758f9fada48c5dd7f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2006.01.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16487584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oyane, Ayako</creatorcontrib><creatorcontrib>Yokoyama, Yoshiro</creatorcontrib><creatorcontrib>Uchida, Masaki</creatorcontrib><creatorcontrib>Ito, Atsuo</creatorcontrib><title>The formation of an antibacterial agent–apatite composite coating on a polymer surface using a metastable calcium phosphate solution</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>A percutaneous device with antibacterial activity and good biocompatibility is desired for clinical applications. Three types of antibacterial agent: lactoferrin (LF), tetracycline (TC), and gatifloxacin (GFLX) were immobilized on the surface of an ethylene-vinyl alcohol copolymer (EVOH) using a liquid phase coating process. In this process, an EVOH plate was alternately dipped in calcium and phosphate ion solutions, and then immersed in a metastable calcium phosphate solution supplemented with 4, 40, or 400
μg/mL of the antibacterial agent. As a result, the antibacterial agent was immobilized on the EVOH surface in the form of an antibacterial agent–apatite composite layer. The amount of immobilized antibacterial agent increased with increasing absorption affinity for apatite in the order: GFLX<TC<LF. On the other hand, the release rate of the antibacterial agent from the composite was ordered in the opposite sense; i.e., LF<TC<GFLX. The composites investigated in this study showed antibacterial activity against
Escherichia coli and
Staphylococcus aureus, and would be useful as materials in percutaneous devices having antibacterial activity and good biocompatibility.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agent</subject><subject>Apatite</subject><subject>Apatites - chemistry</subject><subject>Biocompatible Materials - chemistry</subject><subject>Bone Substitutes</subject><subject>Calcium - chemistry</subject><subject>Calcium Compounds - chemistry</subject><subject>Calcium Phosphates - chemistry</subject><subject>Dose-Response Relationship, Drug</subject><subject>Escherichia coli</subject><subject>Escherichia coli - metabolism</subject><subject>Fluoroquinolones - chemistry</subject><subject>Gatifloxacin (GFLX)</subject><subject>Ions</subject><subject>Kinetics</subject><subject>Lactoferrin (LF)</subject><subject>Lactoferrin - chemistry</subject><subject>Materials Testing</subject><subject>Microscopy, Electron, Scanning</subject><subject>Percutaneous device</subject><subject>Phosphates - chemistry</subject><subject>Polymers - chemistry</subject><subject>Solutions</subject><subject>Spectrometry, X-Ray Emission</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - metabolism</subject><subject>Tetracycline (TC)</subject><subject>Tetracycline - chemistry</subject><subject>Time Factors</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcGO1SAUhonROHdGX8EQF-5agVtKcWdGHU0mcTOuySkc5nLTlgqtyexc-QK-oU8iN72J7jQhgQPff_4cfkJeclZzxtvXx7oPcYQFU4Ah14Kxtma8ZkI_Ijveqa6SmsnHZMd4IyrdcnFBLnM-slKzRjwlF7xtOiW7Zkd-3B2Q-phKuxAnGj2Fqawl9GA3Awr3OC2_vv-EuTALUhvHOebtVG6me1qEQOc4PIyYaF6TB4t0zacnoCMukBfoh8LDYMM60vkQ83woA9Ach_Vk_Iw88WUWfH7er8iXD-_vrj9Wt59vPl2_va1so-RS7X3TM7QghOUopVUg_N465vZ9J7VruHaoW9aB0oz5tozotQcHTWelc8rvr8irre-c4tcV82LGkC0OA0wY12yEFoxLqf4Jcq2U6ERXwDcbaFPMOaE3cwojpAfDmTnFZY7m77jMKS7DuClxFfGLs8vaj-j-SM_5FODdBmD5lG8Bk8k24GTRhYR2MS6G__H5DWWIsnI</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>Oyane, Ayako</creator><creator>Yokoyama, Yoshiro</creator><creator>Uchida, Masaki</creator><creator>Ito, Atsuo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7QQ</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20060601</creationdate><title>The formation of an antibacterial agent–apatite composite coating on a polymer surface using a metastable calcium phosphate solution</title><author>Oyane, Ayako ; Yokoyama, Yoshiro ; Uchida, Masaki ; Ito, Atsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-3f4b0eca22c1e55c7a2f3cd0d3b859d419de9608a7900f6758f9fada48c5dd7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agent</topic><topic>Apatite</topic><topic>Apatites - chemistry</topic><topic>Biocompatible Materials - chemistry</topic><topic>Bone Substitutes</topic><topic>Calcium - chemistry</topic><topic>Calcium Compounds - chemistry</topic><topic>Calcium Phosphates - chemistry</topic><topic>Dose-Response Relationship, Drug</topic><topic>Escherichia coli</topic><topic>Escherichia coli - metabolism</topic><topic>Fluoroquinolones - chemistry</topic><topic>Gatifloxacin (GFLX)</topic><topic>Ions</topic><topic>Kinetics</topic><topic>Lactoferrin (LF)</topic><topic>Lactoferrin - chemistry</topic><topic>Materials Testing</topic><topic>Microscopy, Electron, Scanning</topic><topic>Percutaneous device</topic><topic>Phosphates - chemistry</topic><topic>Polymers - chemistry</topic><topic>Solutions</topic><topic>Spectrometry, X-Ray Emission</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - metabolism</topic><topic>Tetracycline (TC)</topic><topic>Tetracycline - chemistry</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oyane, Ayako</creatorcontrib><creatorcontrib>Yokoyama, Yoshiro</creatorcontrib><creatorcontrib>Uchida, Masaki</creatorcontrib><creatorcontrib>Ito, Atsuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oyane, Ayako</au><au>Yokoyama, Yoshiro</au><au>Uchida, Masaki</au><au>Ito, Atsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The formation of an antibacterial agent–apatite composite coating on a polymer surface using a metastable calcium phosphate solution</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>27</volume><issue>17</issue><spage>3295</spage><epage>3303</epage><pages>3295-3303</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>A percutaneous device with antibacterial activity and good biocompatibility is desired for clinical applications. Three types of antibacterial agent: lactoferrin (LF), tetracycline (TC), and gatifloxacin (GFLX) were immobilized on the surface of an ethylene-vinyl alcohol copolymer (EVOH) using a liquid phase coating process. In this process, an EVOH plate was alternately dipped in calcium and phosphate ion solutions, and then immersed in a metastable calcium phosphate solution supplemented with 4, 40, or 400
μg/mL of the antibacterial agent. As a result, the antibacterial agent was immobilized on the EVOH surface in the form of an antibacterial agent–apatite composite layer. The amount of immobilized antibacterial agent increased with increasing absorption affinity for apatite in the order: GFLX<TC<LF. On the other hand, the release rate of the antibacterial agent from the composite was ordered in the opposite sense; i.e., LF<TC<GFLX. The composites investigated in this study showed antibacterial activity against
Escherichia coli and
Staphylococcus aureus, and would be useful as materials in percutaneous devices having antibacterial activity and good biocompatibility.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>16487584</pmid><doi>10.1016/j.biomaterials.2006.01.029</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Anti-Bacterial Agents - pharmacology Antibacterial agent Apatite Apatites - chemistry Biocompatible Materials - chemistry Bone Substitutes Calcium - chemistry Calcium Compounds - chemistry Calcium Phosphates - chemistry Dose-Response Relationship, Drug Escherichia coli Escherichia coli - metabolism Fluoroquinolones - chemistry Gatifloxacin (GFLX) Ions Kinetics Lactoferrin (LF) Lactoferrin - chemistry Materials Testing Microscopy, Electron, Scanning Percutaneous device Phosphates - chemistry Polymers - chemistry Solutions Spectrometry, X-Ray Emission Staphylococcus aureus Staphylococcus aureus - metabolism Tetracycline (TC) Tetracycline - chemistry Time Factors |
| title | The formation of an antibacterial agent–apatite composite coating on a polymer surface using a metastable calcium phosphate solution |
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