Indirect CD4 + T cell protection against persistent MCMV infection by NK cells requires IFNγ
Host control of mouse cytomegalovirus (MCMV) infection of MHCII salivary gland acinar cells is mediated by CD4 T cells, but how they protect is unclear. Here, we show CD4 T cells control MCMV indirectly in the salivary gland, via IFNγ engagement with uninfected, but antigen MHCII APC and recruitment...
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| Veröffentlicht in: | Journal of general virology 2024-01, Vol.105 (1) |
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| container_title | Journal of general virology |
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| creator | Xie, Wanxiaojie Bruce, Kimberley Stevenson, Philip G Farrell, Helen E |
| description | Host control of mouse cytomegalovirus (MCMV) infection of MHCII
salivary gland acinar cells is mediated by CD4
T cells, but how they protect is unclear. Here, we show CD4
T cells control MCMV indirectly in the salivary gland, via IFNγ engagement with uninfected, but antigen
MHCII
APC and recruitment of NK cells to infected cell foci. This immune mechanism renders direct contact of CD4
T cells with infected cells unnecessary and may represent a host strategy to overcome viral immune evasion. |
| doi_str_mv | 10.1099/jgv.0.001956 |
| format | Article |
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MHCII
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salivary gland acinar cells is mediated by CD4
T cells, but how they protect is unclear. Here, we show CD4
T cells control MCMV indirectly in the salivary gland, via IFNγ engagement with uninfected, but antigen
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APC and recruitment of NK cells to infected cell foci. This immune mechanism renders direct contact of CD4
T cells with infected cells unnecessary and may represent a host strategy to overcome viral immune evasion.</description><subject>Animals</subject><subject>CD4-Positive T-Lymphocytes</subject><subject>Cytomegalovirus Infections</subject><subject>Cytoprotection</subject><subject>Killer Cells, Natural</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Muromegalovirus</subject><subject>T-Lymphocytes</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFOAjEQhhujEURvnk2PJrrYdrfb7dGsokTAC3ozTbedJUtggXbXhOfyPXwmi6Cnycx888-fH6FLSvqUSHk3n332SZ8QKnl6hLo0SXnEwuIYdQlhLKIxFR105v08MEnCxSnqxBkTNLRd9DGsbeXANDh_SPANnmIDiwVeu1UThtWqxnqmq9o3eA3OV76BusHjfPyOq7o8EMUWT15-7zx2sGmDnsfDweT76xydlHrh4eJQe-ht8DjNn6PR69Mwvx9FhknaRNLy2FpuypQTnQlhtbGQMp4Ya7KkkAQMsVyUkgsoaWyAAONMZAK0LDIbxz10vdcNvjct-EYtK78zpGtYtV6FL1IkPBMyoLd71LiV9w5KtXbVUrutokTtAlUhUEXUPtCAXx2U22IJ9h_-SzD-AfZ2cV4</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Xie, Wanxiaojie</creator><creator>Bruce, Kimberley</creator><creator>Stevenson, Philip G</creator><creator>Farrell, Helen E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8889-0439</orcidid><orcidid>https://orcid.org/0000-0002-7214-2767</orcidid><orcidid>https://orcid.org/0000-0002-5838-1024</orcidid><orcidid>https://orcid.org/0000-0002-3520-5060</orcidid></search><sort><creationdate>20240101</creationdate><title>Indirect CD4 + T cell protection against persistent MCMV infection by NK cells requires IFNγ</title><author>Xie, Wanxiaojie ; Bruce, Kimberley ; Stevenson, Philip G ; Farrell, Helen E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c291t-9d53dd5cf650a877dacde6254cdc84b90ec0d57f957ef13ce0e252787ea9b8d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>CD4-Positive T-Lymphocytes</topic><topic>Cytomegalovirus Infections</topic><topic>Cytoprotection</topic><topic>Killer Cells, Natural</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Muromegalovirus</topic><topic>T-Lymphocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Wanxiaojie</creatorcontrib><creatorcontrib>Bruce, Kimberley</creatorcontrib><creatorcontrib>Stevenson, Philip G</creatorcontrib><creatorcontrib>Farrell, Helen E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Wanxiaojie</au><au>Bruce, Kimberley</au><au>Stevenson, Philip G</au><au>Farrell, Helen E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indirect CD4 + T cell protection against persistent MCMV infection by NK cells requires IFNγ</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>105</volume><issue>1</issue><issn>0022-1317</issn><eissn>1465-2099</eissn><abstract>Host control of mouse cytomegalovirus (MCMV) infection of MHCII
salivary gland acinar cells is mediated by CD4
T cells, but how they protect is unclear. Here, we show CD4
T cells control MCMV indirectly in the salivary gland, via IFNγ engagement with uninfected, but antigen
MHCII
APC and recruitment of NK cells to infected cell foci. This immune mechanism renders direct contact of CD4
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| ispartof | Journal of general virology, 2024-01, Vol.105 (1) |
| issn | 0022-1317 1465-2099 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2919745879 |
| source | MEDLINE; Microbiology Society; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Animals CD4-Positive T-Lymphocytes Cytomegalovirus Infections Cytoprotection Killer Cells, Natural Mice Mice, Inbred C57BL Muromegalovirus T-Lymphocytes |
| title | Indirect CD4 + T cell protection against persistent MCMV infection by NK cells requires IFNγ |
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