Effects of Savoring Meditation on Positive Emotions and Pain-Related Brain Function: A Mechanistic Randomized Controlled Trial in People With Rheumatoid Arthritis
Positive emotions are a promising target for intervention in chronic pain, but mixed findings across trials to date suggest that existing interventions may not be optimized to efficiently engage the target. The aim of the current pilot mechanistic randomized controlled trial was to test the effects...
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| Veröffentlicht in: | The journal of pain 2024-07, Vol.25 (7), p.104478, Article 104478 |
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| container_title | The journal of pain |
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| creator | Finan, Patrick H. Hunt, Carly Keaser, Michael L. Smith, Katie Lerman, Sheera Bingham, Clifton O. Barrett, Frederick Garland, Eric L. Zeidan, Fadel Seminowicz, David A. |
| description | Positive emotions are a promising target for intervention in chronic pain, but mixed findings across trials to date suggest that existing interventions may not be optimized to efficiently engage the target. The aim of the current pilot mechanistic randomized controlled trial was to test the effects of a positive emotion-enhancing intervention called Savoring Meditation on pain-related neural and behavioral targets in patients with rheumatoid arthritis. Participants included 44 patients with a physician-confirmed diagnosis of rheumatoid arthritis (n = 29 included in functional magnetic resonance imaging (fMRI) analyses), who were randomized to either Savoring Meditation or a Slow Breathing control. Both meditation interventions were brief (four 20-minute sessions). Self-report measures were collected pre-and post-intervention. An fMRI task was conducted at post-intervention, during which participants practiced the meditation technique on which they had been trained while exposed to non-painful and painful thermal stimuli. Savoring significantly reduced experimental pain intensity ratings relative to rest (P |
| doi_str_mv | 10.1016/j.jpain.2024.01.343 |
| format | Article |
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Savoring Meditation is a novel positive emotion-enhancing intervention designed for patients with chronic pain. The present findings provide preliminary evidence that Savoring Meditation is acutely analgesic, and engages neural and subjective emotional targets that are relevant to pain self-management. Future work should evaluate the clinical translation of these findings.
•Savoring Meditation produced acute analgesia to experimental pain stimuli.•Savoring Meditation increased activation and functional connectivity of the vmPFC.•Savoring Meditation increased the experience of positive emotions and reduced anhedonic symptoms.</description><identifier>ISSN: 1526-5900</identifier><identifier>ISSN: 1528-8447</identifier><identifier>EISSN: 1528-8447</identifier><identifier>DOI: 10.1016/j.jpain.2024.01.343</identifier><identifier>PMID: 38244899</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>fMRI ; Meditation ; Pain ; Positive emotion ; Savoring</subject><ispartof>The journal of pain, 2024-07, Vol.25 (7), p.104478, Article 104478</ispartof><rights>2024 United States Association for the Study of Pain, Inc.</rights><rights>Copyright © 2024. Published by Elsevier Inc.</rights><rights>Copyright © 2024 United States Association for the Study of Pain, Inc. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c354t-a584b05e575669c9bb32db1be9d8d165d7c8959dfbb7eaf71b1efa374293a9e53</cites><orcidid>0000-0001-6819-1112</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpain.2024.01.343$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38244899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Finan, Patrick H.</creatorcontrib><creatorcontrib>Hunt, Carly</creatorcontrib><creatorcontrib>Keaser, Michael L.</creatorcontrib><creatorcontrib>Smith, Katie</creatorcontrib><creatorcontrib>Lerman, Sheera</creatorcontrib><creatorcontrib>Bingham, Clifton O.</creatorcontrib><creatorcontrib>Barrett, Frederick</creatorcontrib><creatorcontrib>Garland, Eric L.</creatorcontrib><creatorcontrib>Zeidan, Fadel</creatorcontrib><creatorcontrib>Seminowicz, David A.</creatorcontrib><title>Effects of Savoring Meditation on Positive Emotions and Pain-Related Brain Function: A Mechanistic Randomized Controlled Trial in People With Rheumatoid Arthritis</title><title>The journal of pain</title><addtitle>J Pain</addtitle><description>Positive emotions are a promising target for intervention in chronic pain, but mixed findings across trials to date suggest that existing interventions may not be optimized to efficiently engage the target. The aim of the current pilot mechanistic randomized controlled trial was to test the effects of a positive emotion-enhancing intervention called Savoring Meditation on pain-related neural and behavioral targets in patients with rheumatoid arthritis. Participants included 44 patients with a physician-confirmed diagnosis of rheumatoid arthritis (n = 29 included in functional magnetic resonance imaging (fMRI) analyses), who were randomized to either Savoring Meditation or a Slow Breathing control. Both meditation interventions were brief (four 20-minute sessions). Self-report measures were collected pre-and post-intervention. An fMRI task was conducted at post-intervention, during which participants practiced the meditation technique on which they had been trained while exposed to non-painful and painful thermal stimuli. Savoring significantly reduced experimental pain intensity ratings relative to rest (P < .001). Savoring also increased cerebral blood flow in the ventromedial prefrontal cortex and increased connectivity between the ventromedial prefrontal cortex and caudate during noxious thermal stimulation relative to Slow Breathing (z = 2.3 voxelwise, false discovery rate cluster corrected P = .05). Participants in the Savoring condition also reported significantly increased positive emotions (ps < .05) and reduced anhedonic symptoms (P < .01) from pre- to post-intervention. These findings suggest that Savoring recruits reward-enhancing corticostriatal circuits in the face of pain, and future work should extend these findings to evaluate if these mechanisms of Savoring are associated with improved clinical pain outcomes in diverse patient populations.
Savoring Meditation is a novel positive emotion-enhancing intervention designed for patients with chronic pain. The present findings provide preliminary evidence that Savoring Meditation is acutely analgesic, and engages neural and subjective emotional targets that are relevant to pain self-management. Future work should evaluate the clinical translation of these findings.
•Savoring Meditation produced acute analgesia to experimental pain stimuli.•Savoring Meditation increased activation and functional connectivity of the vmPFC.•Savoring Meditation increased the experience of positive emotions and reduced anhedonic symptoms.</description><subject>fMRI</subject><subject>Meditation</subject><subject>Pain</subject><subject>Positive emotion</subject><subject>Savoring</subject><issn>1526-5900</issn><issn>1528-8447</issn><issn>1528-8447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kdFqFDEUhoMotlafQJBcejNjMklmJoIX67JVoaXLWvEyZJIzbpaZyTbJLOjj9Emb7VYvhUDOCd85P-FD6C0lJSW0_rArd3vtprIiFS8JLRlnz9A5FVVbtJw3zx_ruhCSkDP0KsYdIZSKpnmJzlhbcd5KeY7uV30PJkXse_xdH3xw0y98DdYlnZyfcD5rH11yB8Cr0R_fItaTxescXWxg0Aks_hxyhy_nyRyBj3iRV5itnlxMzuBN5v3o_mRw6acU_DDk8jY4PeA8tga_HwD_dGmLN1uYR528s3gR0jbk4Pgavej1EOHN032Bflyubpdfi6ubL9-Wi6vCMMFToUXLOyJANKKupZFdxyrb0Q6kbS2thW1MK4W0fdc1oPuGdhR6zRpeSaYlCHaB3p_27oO_myEmNbpoYBj0BH6OqpJUNlzQimeUnVATfIwBerUPbtTht6JEHeWonXqUo45yFKEqy8lT754C5m4E-2_mr40MfDoBkL95cBBUNA4mk3WELElZ7_4b8ADX9aR4</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Finan, Patrick H.</creator><creator>Hunt, Carly</creator><creator>Keaser, Michael L.</creator><creator>Smith, Katie</creator><creator>Lerman, Sheera</creator><creator>Bingham, Clifton O.</creator><creator>Barrett, Frederick</creator><creator>Garland, Eric L.</creator><creator>Zeidan, Fadel</creator><creator>Seminowicz, David A.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6819-1112</orcidid></search><sort><creationdate>20240701</creationdate><title>Effects of Savoring Meditation on Positive Emotions and Pain-Related Brain Function: A Mechanistic Randomized Controlled Trial in People With Rheumatoid Arthritis</title><author>Finan, Patrick H. ; Hunt, Carly ; Keaser, Michael L. ; Smith, Katie ; Lerman, Sheera ; Bingham, Clifton O. ; Barrett, Frederick ; Garland, Eric L. ; Zeidan, Fadel ; Seminowicz, David A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-a584b05e575669c9bb32db1be9d8d165d7c8959dfbb7eaf71b1efa374293a9e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>fMRI</topic><topic>Meditation</topic><topic>Pain</topic><topic>Positive emotion</topic><topic>Savoring</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Finan, Patrick H.</creatorcontrib><creatorcontrib>Hunt, Carly</creatorcontrib><creatorcontrib>Keaser, Michael L.</creatorcontrib><creatorcontrib>Smith, Katie</creatorcontrib><creatorcontrib>Lerman, Sheera</creatorcontrib><creatorcontrib>Bingham, Clifton O.</creatorcontrib><creatorcontrib>Barrett, Frederick</creatorcontrib><creatorcontrib>Garland, Eric L.</creatorcontrib><creatorcontrib>Zeidan, Fadel</creatorcontrib><creatorcontrib>Seminowicz, David A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of pain</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Finan, Patrick H.</au><au>Hunt, Carly</au><au>Keaser, Michael L.</au><au>Smith, Katie</au><au>Lerman, Sheera</au><au>Bingham, Clifton O.</au><au>Barrett, Frederick</au><au>Garland, Eric L.</au><au>Zeidan, Fadel</au><au>Seminowicz, David A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Savoring Meditation on Positive Emotions and Pain-Related Brain Function: A Mechanistic Randomized Controlled Trial in People With Rheumatoid Arthritis</atitle><jtitle>The journal of pain</jtitle><addtitle>J Pain</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>25</volume><issue>7</issue><spage>104478</spage><pages>104478-</pages><artnum>104478</artnum><issn>1526-5900</issn><issn>1528-8447</issn><eissn>1528-8447</eissn><abstract>Positive emotions are a promising target for intervention in chronic pain, but mixed findings across trials to date suggest that existing interventions may not be optimized to efficiently engage the target. The aim of the current pilot mechanistic randomized controlled trial was to test the effects of a positive emotion-enhancing intervention called Savoring Meditation on pain-related neural and behavioral targets in patients with rheumatoid arthritis. Participants included 44 patients with a physician-confirmed diagnosis of rheumatoid arthritis (n = 29 included in functional magnetic resonance imaging (fMRI) analyses), who were randomized to either Savoring Meditation or a Slow Breathing control. Both meditation interventions were brief (four 20-minute sessions). Self-report measures were collected pre-and post-intervention. An fMRI task was conducted at post-intervention, during which participants practiced the meditation technique on which they had been trained while exposed to non-painful and painful thermal stimuli. Savoring significantly reduced experimental pain intensity ratings relative to rest (P < .001). Savoring also increased cerebral blood flow in the ventromedial prefrontal cortex and increased connectivity between the ventromedial prefrontal cortex and caudate during noxious thermal stimulation relative to Slow Breathing (z = 2.3 voxelwise, false discovery rate cluster corrected P = .05). Participants in the Savoring condition also reported significantly increased positive emotions (ps < .05) and reduced anhedonic symptoms (P < .01) from pre- to post-intervention. These findings suggest that Savoring recruits reward-enhancing corticostriatal circuits in the face of pain, and future work should extend these findings to evaluate if these mechanisms of Savoring are associated with improved clinical pain outcomes in diverse patient populations.
Savoring Meditation is a novel positive emotion-enhancing intervention designed for patients with chronic pain. The present findings provide preliminary evidence that Savoring Meditation is acutely analgesic, and engages neural and subjective emotional targets that are relevant to pain self-management. Future work should evaluate the clinical translation of these findings.
•Savoring Meditation produced acute analgesia to experimental pain stimuli.•Savoring Meditation increased activation and functional connectivity of the vmPFC.•Savoring Meditation increased the experience of positive emotions and reduced anhedonic symptoms.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38244899</pmid><doi>10.1016/j.jpain.2024.01.343</doi><orcidid>https://orcid.org/0000-0001-6819-1112</orcidid><oa>free_for_read</oa></addata></record> |
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| title | Effects of Savoring Meditation on Positive Emotions and Pain-Related Brain Function: A Mechanistic Randomized Controlled Trial in People With Rheumatoid Arthritis |
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