Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: An American population‐based study
The association between psoriasis and cardiovascular disease (CVD) has long been discussed and continually refined. However, there is currently a lack of prospective studies on the cardiovascular risk attributed to psoriasis in the United States general population. Representative adult participants...
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| Veröffentlicht in: | Experimental dermatology 2024-01, Vol.33 (1), p.e15010-n/a |
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| creator | Kan, Junyan Chen, Qitao Tao, Qiuwei Wu, Lida Wang, Dongchen Jiang, Zihao Du, Xufeng Gu, Yue Gu, Yong |
| description | The association between psoriasis and cardiovascular disease (CVD) has long been discussed and continually refined. However, there is currently a lack of prospective studies on the cardiovascular risk attributed to psoriasis in the United States general population. Representative adult participants were selected from the National Health and Nutrition Examination Survey (NHANES). Risks of cardiovascular symptoms and diseases prevalence were evaluated between participants with and without psoriasis. The hazards for all‐cause mortality and CVD mortality were stratified by psoriasis status. Mediation analysis was then conducted to identify potential mediators between psoriasis and cardiac death. Overall, 19 741 participants were included in the current study, 542 (2.7%) had psoriasis and 19 199 (97.3%) did not have psoriasis. After adjusting for known CVD risk factors, odds for hypertension (OR = 1.37, 95% CI: 1.13–1.66, p = 0.001), hypercholesterolemia (OR = 1.37, 95% CI: 1.13–1.64, p |
| doi_str_mv | 10.1111/exd.15010 |
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We did not receive any request to submit a graphical during the submission process. If the editorial team deems it necessary, we are willing to provide one. In the meantime, if there is a template available, please provide it to us.</description><identifier>ISSN: 0906-6705</identifier><identifier>EISSN: 1600-0625</identifier><identifier>DOI: 10.1111/exd.15010</identifier><identifier>PMID: 38284207</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Angina ; Angina pectoris ; Cardiovascular disease ; Cardiovascular diseases ; cardiovascular mortality ; Hypercholesterolemia ; Mortality ; NHANES ; Population studies ; Psoriasis ; Risk factors ; Uric acid</subject><ispartof>Experimental dermatology, 2024-01, Vol.33 (1), p.e15010-n/a</ispartof><rights>2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2024 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-2a0fffe9d261a08a9a94fba779d7dd2e930b6b375228cd105e9e4b28fdc0185a3</citedby><cites>FETCH-LOGICAL-c3530-2a0fffe9d261a08a9a94fba779d7dd2e930b6b375228cd105e9e4b28fdc0185a3</cites><orcidid>0000-0001-9259-179X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fexd.15010$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fexd.15010$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38284207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kan, Junyan</creatorcontrib><creatorcontrib>Chen, Qitao</creatorcontrib><creatorcontrib>Tao, Qiuwei</creatorcontrib><creatorcontrib>Wu, Lida</creatorcontrib><creatorcontrib>Wang, Dongchen</creatorcontrib><creatorcontrib>Jiang, Zihao</creatorcontrib><creatorcontrib>Du, Xufeng</creatorcontrib><creatorcontrib>Gu, Yue</creatorcontrib><creatorcontrib>Gu, Yong</creatorcontrib><title>Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: An American population‐based study</title><title>Experimental dermatology</title><addtitle>Exp Dermatol</addtitle><description>The association between psoriasis and cardiovascular disease (CVD) has long been discussed and continually refined. However, there is currently a lack of prospective studies on the cardiovascular risk attributed to psoriasis in the United States general population. Representative adult participants were selected from the National Health and Nutrition Examination Survey (NHANES). Risks of cardiovascular symptoms and diseases prevalence were evaluated between participants with and without psoriasis. The hazards for all‐cause mortality and CVD mortality were stratified by psoriasis status. Mediation analysis was then conducted to identify potential mediators between psoriasis and cardiac death. Overall, 19 741 participants were included in the current study, 542 (2.7%) had psoriasis and 19 199 (97.3%) did not have psoriasis. After adjusting for known CVD risk factors, odds for hypertension (OR = 1.37, 95% CI: 1.13–1.66, p = 0.001), hypercholesterolemia (OR = 1.37, 95% CI: 1.13–1.64, p < 0.001) and angina pectoris (OR = 1.74, 95% CI: 1.11–2.60, p = 0.011) were higher in psoriasis patients. Compared with participants without psoriasis, moderate/severe but not mild patients showed significantly higher CVD mortality (HR = 2.55, 95% CI: 1.27–5.15, p = 0.009). This result was supported by subgroup analyses. Mediation analysis further suggested that the direct effect of moderate/severe psoriasis on CVD mortality accounted for 81.4% (65.8%–97.1%). Besides, the indirect effect might derive from disturbance of serum albumin, urea nitrogen and uric acid. Moderate‐to‐severe psoriasis is an independent risk factor for cardiovascular disease, making it necessary to regularly conduct cardiovascular disease‐related examinations for patients with higher severity of psoriasis in clinical settings.
We did not receive any request to submit a graphical during the submission process. If the editorial team deems it necessary, we are willing to provide one. In the meantime, if there is a template available, please provide it to us.</description><subject>Angina</subject><subject>Angina pectoris</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>cardiovascular mortality</subject><subject>Hypercholesterolemia</subject><subject>Mortality</subject><subject>NHANES</subject><subject>Population studies</subject><subject>Psoriasis</subject><subject>Risk factors</subject><subject>Uric acid</subject><issn>0906-6705</issn><issn>1600-0625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp10ctO3DAUBmALtYLhsuAFkKVuyiJw7Ewu7m5E6UVCggVI7KIT-0QYkjjYydCRuugj9Bn7JPUwlAVSz8abT798zs_YoYATEeeUfpgTkYGALTYTOUACuczesRkoyJO8gGyH7YZwDyCKtMi22U5aynIuoZixn1fehYH0aJfEaYnthKN1PXcN1-iNdUsMemrRc2_DA8fe8M75EVs7rrjt-RA59WPgT3a840Nw3mKw4RNf9HzRkbcaI3JDjFjn_vn1u8ZAhodxMqt99r7BNtDBy7vHbr6cX599Sy4uv34_W1wkOs1SSCRC0zSkjMwFQokK1bypsSiUKYyRpFKo8zpuJmWpjYCMFM1rWTZGgygzTPfYx03u4N3jRGGsOhs0tS325KZQSSVUMU9VJiL98Ibeu8n38XfPKp5NlGt1vFE6Xi94aqrB2w79qhJQrSupYiXVcyXRHr0kTnVH5lX-6yCC0w14si2t_p9Und9-3kT-BbzwmIc</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Kan, Junyan</creator><creator>Chen, Qitao</creator><creator>Tao, Qiuwei</creator><creator>Wu, Lida</creator><creator>Wang, Dongchen</creator><creator>Jiang, Zihao</creator><creator>Du, Xufeng</creator><creator>Gu, Yue</creator><creator>Gu, Yong</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9259-179X</orcidid></search><sort><creationdate>202401</creationdate><title>Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: An American population‐based study</title><author>Kan, Junyan ; Chen, Qitao ; Tao, Qiuwei ; Wu, Lida ; Wang, Dongchen ; Jiang, Zihao ; Du, Xufeng ; Gu, Yue ; Gu, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-2a0fffe9d261a08a9a94fba779d7dd2e930b6b375228cd105e9e4b28fdc0185a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Angina</topic><topic>Angina pectoris</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>cardiovascular mortality</topic><topic>Hypercholesterolemia</topic><topic>Mortality</topic><topic>NHANES</topic><topic>Population studies</topic><topic>Psoriasis</topic><topic>Risk factors</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kan, Junyan</creatorcontrib><creatorcontrib>Chen, Qitao</creatorcontrib><creatorcontrib>Tao, Qiuwei</creatorcontrib><creatorcontrib>Wu, Lida</creatorcontrib><creatorcontrib>Wang, Dongchen</creatorcontrib><creatorcontrib>Jiang, Zihao</creatorcontrib><creatorcontrib>Du, Xufeng</creatorcontrib><creatorcontrib>Gu, Yue</creatorcontrib><creatorcontrib>Gu, Yong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kan, Junyan</au><au>Chen, Qitao</au><au>Tao, Qiuwei</au><au>Wu, Lida</au><au>Wang, Dongchen</au><au>Jiang, Zihao</au><au>Du, Xufeng</au><au>Gu, Yue</au><au>Gu, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: An American population‐based study</atitle><jtitle>Experimental dermatology</jtitle><addtitle>Exp Dermatol</addtitle><date>2024-01</date><risdate>2024</risdate><volume>33</volume><issue>1</issue><spage>e15010</spage><epage>n/a</epage><pages>e15010-n/a</pages><issn>0906-6705</issn><eissn>1600-0625</eissn><abstract>The association between psoriasis and cardiovascular disease (CVD) has long been discussed and continually refined. However, there is currently a lack of prospective studies on the cardiovascular risk attributed to psoriasis in the United States general population. Representative adult participants were selected from the National Health and Nutrition Examination Survey (NHANES). Risks of cardiovascular symptoms and diseases prevalence were evaluated between participants with and without psoriasis. The hazards for all‐cause mortality and CVD mortality were stratified by psoriasis status. Mediation analysis was then conducted to identify potential mediators between psoriasis and cardiac death. Overall, 19 741 participants were included in the current study, 542 (2.7%) had psoriasis and 19 199 (97.3%) did not have psoriasis. After adjusting for known CVD risk factors, odds for hypertension (OR = 1.37, 95% CI: 1.13–1.66, p = 0.001), hypercholesterolemia (OR = 1.37, 95% CI: 1.13–1.64, p < 0.001) and angina pectoris (OR = 1.74, 95% CI: 1.11–2.60, p = 0.011) were higher in psoriasis patients. Compared with participants without psoriasis, moderate/severe but not mild patients showed significantly higher CVD mortality (HR = 2.55, 95% CI: 1.27–5.15, p = 0.009). This result was supported by subgroup analyses. Mediation analysis further suggested that the direct effect of moderate/severe psoriasis on CVD mortality accounted for 81.4% (65.8%–97.1%). Besides, the indirect effect might derive from disturbance of serum albumin, urea nitrogen and uric acid. Moderate‐to‐severe psoriasis is an independent risk factor for cardiovascular disease, making it necessary to regularly conduct cardiovascular disease‐related examinations for patients with higher severity of psoriasis in clinical settings.
We did not receive any request to submit a graphical during the submission process. If the editorial team deems it necessary, we are willing to provide one. In the meantime, if there is a template available, please provide it to us.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38284207</pmid><doi>10.1111/exd.15010</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-9259-179X</orcidid></addata></record> |
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| subjects | Angina Angina pectoris Cardiovascular disease Cardiovascular diseases cardiovascular mortality Hypercholesterolemia Mortality NHANES Population studies Psoriasis Risk factors Uric acid |
| title | Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: An American population‐based study |
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