Fluoxetine exerts anti‐inflammatory effects on human epidermal keratinocytes and suppresses their endothelin release

Fluoxetine is a safe antidepressant with remarkable anti‐inflammatory actions; therefore, we aimed to investigate its effects on immortalized (HaCaT) as well as primary human epidermal keratinocytes in a polyinosinic‐polycytidylic acid (p(I:C))‐induced inflammatory model. We found that a non‐cytotox...

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Veröffentlicht in:	Experimental dermatology 2024-01, Vol.33 (1), p.e14988-n/a
Hauptverfasser:	Tóth, Kinga Fanni, Ádám, Dorottya, Arany, József, Ramirez, Yesid A., Bíró, Tamás, Drake, Jennifer I., O'Mahony, Alison, Szöllősi, Attila Gábor, Póliska, Szilárd, Kilić, Ana, Soeberdt, Michael, Abels, Christoph, Oláh, Attila
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Anti-inflammatory agents atopic dermatitis COVID‐19 Cytokines Cytotoxicity endothelin Endothelins Enzyme-linked immunosorbent assay Fluoxetine Inflammation itch keratinocyte Keratinocytes MAP kinase phosphoinositide 3‐kinase polyinosinic‐polycytidylic acid Polymerase chain reaction toll‐like receptor 3
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