Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin

Thymic stromal lymphopoietin (TSLP) is an epithelial-derived pro-inflammatory cytokine involved in the development of asthma and other atopic diseases. We used Bicycle Therapeutics’ proprietary phage display platform to identify bicyclic peptides (Bicycles) with high affinity for TSLP, a target that...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-02, Vol.67 (3), p.2220-2235
Hauptverfasser:	Narjes, Frank, Edfeldt, Fredrik, Petersen, Jens, Öster, Linda, Hamblet, Corinne, Bird, James, Bold, Peter, Rae, Rebecca, Bäck, Elisabeth, Stomilovic, Stina, Zlatoidsky, Pavol, Svensson, Tor, Hidestål, Lotta, Kunalingam, Lavaniya, Shamovsky, Igor, De Maria, Leonardo, Gordon, Euan, Lewis, Richard J., Watcham, Sophie, van Rietschoten, Katerine, Mudd, Gemma E., Harrison, Helen, Chen, Liuhong, Skynner, Michael J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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