Exploring the Therapeutic Significance of microRNAs and lncRNAs in Kidney Diseases
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two crucial classes of transcripts that belong to the major group of non-coding RNAs (ncRNAs). These RNA molecules have significant influence over diverse molecular processes due to their crucial role as regulators of gene expression. However...
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| Veröffentlicht in: | Genes 2024-01, Vol.15 (1), p.123 |
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| creator | Bravo-Vázquez, Luis Alberto Paul, Sujay Colín-Jurado, Miriam Guadalupe Márquez-Gallardo, Luis David Castañón-Cortés, Luis Germán Banerjee, Antara Pathak, Surajit Duttaroy, Asim K |
| description | MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two crucial classes of transcripts that belong to the major group of non-coding RNAs (ncRNAs). These RNA molecules have significant influence over diverse molecular processes due to their crucial role as regulators of gene expression. However, the dysregulated expression of these ncRNAs constitutes a fundamental factor in the etiology and progression of a wide variety of multifaceted human diseases, including kidney diseases. In this context, over the past years, compelling evidence has shown that miRNAs and lncRNAs could be prospective targets for the development of next-generation drugs against kidney diseases as they participate in a number of disease-associated processes, such as podocyte and nephron death, renal fibrosis, inflammation, transition from acute kidney injury to chronic kidney disease, renal vascular changes, sepsis, pyroptosis, and apoptosis. Hence, in this current review, we critically analyze the recent findings concerning the therapeutic inferences of miRNAs and lncRNAs in the pathophysiological context of kidney diseases. Additionally, with the aim of driving advances in the formulation of ncRNA-based drugs tailored for the management of kidney diseases, we discuss some of the key challenges and future prospects that should be addressed in forthcoming investigations. |
| doi_str_mv | 10.3390/genes15010123 |
| format | Article |
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Additionally, with the aim of driving advances in the formulation of ncRNA-based drugs tailored for the management of kidney diseases, we discuss some of the key challenges and future prospects that should be addressed in forthcoming investigations.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes15010123</identifier><identifier>PMID: 38275604</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Apoptosis ; Biomarkers ; Blood pressure ; Cell growth ; Chronic kidney failure ; Development and progression ; Drug development ; Epigenetics ; Fibrosis ; Gene expression ; Genes ; Health aspects ; Humans ; Inflammation ; Kidney diseases ; Mediation ; Metabolism ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miRNA ; Non-coding RNA ; Proteins ; Pyroptosis ; Renal Insufficiency, Chronic - drug therapy ; Renal Insufficiency, Chronic - genetics ; Renal Insufficiency, Chronic - metabolism ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; RNA, Untranslated ; Sepsis ; Transplants & implants</subject><ispartof>Genes, 2024-01, Vol.15 (1), p.123</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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These RNA molecules have significant influence over diverse molecular processes due to their crucial role as regulators of gene expression. However, the dysregulated expression of these ncRNAs constitutes a fundamental factor in the etiology and progression of a wide variety of multifaceted human diseases, including kidney diseases. In this context, over the past years, compelling evidence has shown that miRNAs and lncRNAs could be prospective targets for the development of next-generation drugs against kidney diseases as they participate in a number of disease-associated processes, such as podocyte and nephron death, renal fibrosis, inflammation, transition from acute kidney injury to chronic kidney disease, renal vascular changes, sepsis, pyroptosis, and apoptosis. Hence, in this current review, we critically analyze the recent findings concerning the therapeutic inferences of miRNAs and lncRNAs in the pathophysiological context of kidney diseases. 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| subjects | Apoptosis Biomarkers Blood pressure Cell growth Chronic kidney failure Development and progression Drug development Epigenetics Fibrosis Gene expression Genes Health aspects Humans Inflammation Kidney diseases Mediation Metabolism MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Non-coding RNA Proteins Pyroptosis Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - genetics Renal Insufficiency, Chronic - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Untranslated Sepsis Transplants & implants |
| title | Exploring the Therapeutic Significance of microRNAs and lncRNAs in Kidney Diseases |
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