Exposome and basal cell carcinoma: a multicenter case–control study
Background While ultraviolet radiation (UVR) present in sunlight is recognized as the main etiological agent of skin cancer, the most frequent form of which is basal cell carcinoma (BCC), other exposome factors like pollution, diet, and lifestyle may also contribute. This study aimed to investigate...
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| Veröffentlicht in: | International journal of dermatology 2024-07, Vol.63 (7), p.907-915 |
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| creator | Navarro‐Bielsa, Alba Gracia‐Cazaña, Tamara Almagro, Manuel De‐la‐Fuente‐Meira, Sonia Florez, Ángeles Yélamos, Oriol Montero‐Vilchez, Trinidad González‐Cruz, Carlos Diago, Adrián Abadías‐Granado, Isabel Fuentelsaz, Victoria Colmenero, María Bañuls, Jose Arias‐Santiago, Salvador Buendía‐Eisman, Agustín Almenara‐Blasco, Manuel Gil‐Pallares, Pedro Gilaberte, Yolanda |
| description | Background
While ultraviolet radiation (UVR) present in sunlight is recognized as the main etiological agent of skin cancer, the most frequent form of which is basal cell carcinoma (BCC), other exposome factors like pollution, diet, and lifestyle may also contribute. This study aimed to investigate the association of BCC and exposome‐related factors in the Spanish population.
Methods
BCC cases (n = 119) and controls (n = 127) with no history of skin cancer were recruited between April 2020 and August 2022 by 13 dermatologists throughout Spain in this prospective multicenter case–control study.
Results
The BCC group had a higher proportion of outdoor workers, more years of UVR exposure, and a greater consumption of drugs (statins, ASA, hydrochlorothiazide, ACE inhibitors and omeprazole), P |
| doi_str_mv | 10.1111/ijd.17026 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2919742873</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3075580571</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3486-b7a5431951ac3db05700459b4d5a6f52846039dd4213877125f86f9f1fe143a33</originalsourceid><addsrcrecordid>eNp1kE1OwzAQhS0EoqWw4AIoEhtYpPVvbLNDpUBRJTawtpzYkVIlcbETQXfcgRtyElxaWCAxixmN5tObpwfAKYJjFGtSLc0YcYizPTBEJGMpzQjeB0MIEUolZHIAjkJYxpVgRA_BgAgsMKZ0CGazt5ULrrGJbk2S66DrpLB1bNoXVesafZXopOnrrips21kfD8F-vn8Uru28q5PQ9WZ9DA5KXQd7spsj8Hw7e5rep4vHu_n0epEWhIoszblmlCDJkC6IySHjEFImc2qYzkqGBc0gkcZQjIjgHGFWiqyUJSotokQTMgIXW92Vdy-9DZ1qqrCxq1vr-qCwRJJTLPgGPf-DLl3v2-hOEcgZE_E7itTlliq8C8HbUq181Wi_VgiqTbYqZqu-s43s2U6xzxtrfsmfMCMw2QKvVW3X_yup-cPNVvILtKuBHQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3075580571</pqid></control><display><type>article</type><title>Exposome and basal cell carcinoma: a multicenter case–control study</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Navarro‐Bielsa, Alba ; Gracia‐Cazaña, Tamara ; Almagro, Manuel ; De‐la‐Fuente‐Meira, Sonia ; Florez, Ángeles ; Yélamos, Oriol ; Montero‐Vilchez, Trinidad ; González‐Cruz, Carlos ; Diago, Adrián ; Abadías‐Granado, Isabel ; Fuentelsaz, Victoria ; Colmenero, María ; Bañuls, Jose ; Arias‐Santiago, Salvador ; Buendía‐Eisman, Agustín ; Almenara‐Blasco, Manuel ; Gil‐Pallares, Pedro ; Gilaberte, Yolanda</creator><creatorcontrib>Navarro‐Bielsa, Alba ; Gracia‐Cazaña, Tamara ; Almagro, Manuel ; De‐la‐Fuente‐Meira, Sonia ; Florez, Ángeles ; Yélamos, Oriol ; Montero‐Vilchez, Trinidad ; González‐Cruz, Carlos ; Diago, Adrián ; Abadías‐Granado, Isabel ; Fuentelsaz, Victoria ; Colmenero, María ; Bañuls, Jose ; Arias‐Santiago, Salvador ; Buendía‐Eisman, Agustín ; Almenara‐Blasco, Manuel ; Gil‐Pallares, Pedro ; Gilaberte, Yolanda</creatorcontrib><description>Background
While ultraviolet radiation (UVR) present in sunlight is recognized as the main etiological agent of skin cancer, the most frequent form of which is basal cell carcinoma (BCC), other exposome factors like pollution, diet, and lifestyle may also contribute. This study aimed to investigate the association of BCC and exposome‐related factors in the Spanish population.
Methods
BCC cases (n = 119) and controls (n = 127) with no history of skin cancer were recruited between April 2020 and August 2022 by 13 dermatologists throughout Spain in this prospective multicenter case–control study.
Results
The BCC group had a higher proportion of outdoor workers, more years of UVR exposure, and a greater consumption of drugs (statins, ASA, hydrochlorothiazide, ACE inhibitors and omeprazole), P < 0.05. Avoidance of sun exposure was the most used photoprotection measure in both groups. The use of hats or caps was higher in the BCC group (P = 0.01). The solar protection factor (SPF) used 15 years previously was higher in the control group (P = 0.04). The control group had a higher daily screen time (P < 0.001), and practiced more relaxation activities (P = 0.03). Higher linolenic acid intake and lower coffee consumption were the only dietary variables associated with BCC (P < 0.05). Statistical significance for all the aforementioned variables was maintained in the multivariate analysis (P < 0.05).
Conclusions
The study found a significant association between BCC and multiple exposome‐related factors in addition to chronic sun exposure in the Spanish population. Primary prevention strategies should target specific populations, such as outdoor workers, promoting sun‐safe behaviors and stress‐reducing activities, and also adequate skin photoprotection in patients on certain medications associated with increased BCC risk.</description><identifier>ISSN: 0011-9059</identifier><identifier>ISSN: 1365-4632</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/ijd.17026</identifier><identifier>PMID: 38282244</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Angiotensin-converting enzyme inhibitors ; Basal cell carcinoma ; Cancer ; Case studies ; Coffee ; Dietary intake ; Exposure ; Hydrochlorothiazide ; Linolenic acid ; Multivariate analysis ; Occupational exposure ; Omeprazole ; Population studies ; Skin cancer ; Statins ; Statistical analysis ; Sun ; Ultraviolet radiation</subject><ispartof>International journal of dermatology, 2024-07, Vol.63 (7), p.907-915</ispartof><rights>2024 The Authors. published by Wiley Periodicals LLC on behalf of the International Society of Dermatology.</rights><rights>2024 The Authors. International Journal of Dermatology published by Wiley Periodicals LLC on behalf of the International Society of Dermatology.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3486-b7a5431951ac3db05700459b4d5a6f52846039dd4213877125f86f9f1fe143a33</cites><orcidid>0000-0003-4035-7955 ; 0000-0003-1171-6007 ; 0000-0001-8469-1942 ; 0000-0002-4350-401X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijd.17026$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijd.17026$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38282244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Navarro‐Bielsa, Alba</creatorcontrib><creatorcontrib>Gracia‐Cazaña, Tamara</creatorcontrib><creatorcontrib>Almagro, Manuel</creatorcontrib><creatorcontrib>De‐la‐Fuente‐Meira, Sonia</creatorcontrib><creatorcontrib>Florez, Ángeles</creatorcontrib><creatorcontrib>Yélamos, Oriol</creatorcontrib><creatorcontrib>Montero‐Vilchez, Trinidad</creatorcontrib><creatorcontrib>González‐Cruz, Carlos</creatorcontrib><creatorcontrib>Diago, Adrián</creatorcontrib><creatorcontrib>Abadías‐Granado, Isabel</creatorcontrib><creatorcontrib>Fuentelsaz, Victoria</creatorcontrib><creatorcontrib>Colmenero, María</creatorcontrib><creatorcontrib>Bañuls, Jose</creatorcontrib><creatorcontrib>Arias‐Santiago, Salvador</creatorcontrib><creatorcontrib>Buendía‐Eisman, Agustín</creatorcontrib><creatorcontrib>Almenara‐Blasco, Manuel</creatorcontrib><creatorcontrib>Gil‐Pallares, Pedro</creatorcontrib><creatorcontrib>Gilaberte, Yolanda</creatorcontrib><title>Exposome and basal cell carcinoma: a multicenter case–control study</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background
While ultraviolet radiation (UVR) present in sunlight is recognized as the main etiological agent of skin cancer, the most frequent form of which is basal cell carcinoma (BCC), other exposome factors like pollution, diet, and lifestyle may also contribute. This study aimed to investigate the association of BCC and exposome‐related factors in the Spanish population.
Methods
BCC cases (n = 119) and controls (n = 127) with no history of skin cancer were recruited between April 2020 and August 2022 by 13 dermatologists throughout Spain in this prospective multicenter case–control study.
Results
The BCC group had a higher proportion of outdoor workers, more years of UVR exposure, and a greater consumption of drugs (statins, ASA, hydrochlorothiazide, ACE inhibitors and omeprazole), P < 0.05. Avoidance of sun exposure was the most used photoprotection measure in both groups. The use of hats or caps was higher in the BCC group (P = 0.01). The solar protection factor (SPF) used 15 years previously was higher in the control group (P = 0.04). The control group had a higher daily screen time (P < 0.001), and practiced more relaxation activities (P = 0.03). Higher linolenic acid intake and lower coffee consumption were the only dietary variables associated with BCC (P < 0.05). Statistical significance for all the aforementioned variables was maintained in the multivariate analysis (P < 0.05).
Conclusions
The study found a significant association between BCC and multiple exposome‐related factors in addition to chronic sun exposure in the Spanish population. Primary prevention strategies should target specific populations, such as outdoor workers, promoting sun‐safe behaviors and stress‐reducing activities, and also adequate skin photoprotection in patients on certain medications associated with increased BCC risk.</description><subject>Angiotensin-converting enzyme inhibitors</subject><subject>Basal cell carcinoma</subject><subject>Cancer</subject><subject>Case studies</subject><subject>Coffee</subject><subject>Dietary intake</subject><subject>Exposure</subject><subject>Hydrochlorothiazide</subject><subject>Linolenic acid</subject><subject>Multivariate analysis</subject><subject>Occupational exposure</subject><subject>Omeprazole</subject><subject>Population studies</subject><subject>Skin cancer</subject><subject>Statins</subject><subject>Statistical analysis</subject><subject>Sun</subject><subject>Ultraviolet radiation</subject><issn>0011-9059</issn><issn>1365-4632</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kE1OwzAQhS0EoqWw4AIoEhtYpPVvbLNDpUBRJTawtpzYkVIlcbETQXfcgRtyElxaWCAxixmN5tObpwfAKYJjFGtSLc0YcYizPTBEJGMpzQjeB0MIEUolZHIAjkJYxpVgRA_BgAgsMKZ0CGazt5ULrrGJbk2S66DrpLB1bNoXVesafZXopOnrrips21kfD8F-vn8Uru28q5PQ9WZ9DA5KXQd7spsj8Hw7e5rep4vHu_n0epEWhIoszblmlCDJkC6IySHjEFImc2qYzkqGBc0gkcZQjIjgHGFWiqyUJSotokQTMgIXW92Vdy-9DZ1qqrCxq1vr-qCwRJJTLPgGPf-DLl3v2-hOEcgZE_E7itTlliq8C8HbUq181Wi_VgiqTbYqZqu-s43s2U6xzxtrfsmfMCMw2QKvVW3X_yup-cPNVvILtKuBHQ</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Navarro‐Bielsa, Alba</creator><creator>Gracia‐Cazaña, Tamara</creator><creator>Almagro, Manuel</creator><creator>De‐la‐Fuente‐Meira, Sonia</creator><creator>Florez, Ángeles</creator><creator>Yélamos, Oriol</creator><creator>Montero‐Vilchez, Trinidad</creator><creator>González‐Cruz, Carlos</creator><creator>Diago, Adrián</creator><creator>Abadías‐Granado, Isabel</creator><creator>Fuentelsaz, Victoria</creator><creator>Colmenero, María</creator><creator>Bañuls, Jose</creator><creator>Arias‐Santiago, Salvador</creator><creator>Buendía‐Eisman, Agustín</creator><creator>Almenara‐Blasco, Manuel</creator><creator>Gil‐Pallares, Pedro</creator><creator>Gilaberte, Yolanda</creator><general>Blackwell Publishing Ltd</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4035-7955</orcidid><orcidid>https://orcid.org/0000-0003-1171-6007</orcidid><orcidid>https://orcid.org/0000-0001-8469-1942</orcidid><orcidid>https://orcid.org/0000-0002-4350-401X</orcidid></search><sort><creationdate>202407</creationdate><title>Exposome and basal cell carcinoma: a multicenter case–control study</title><author>Navarro‐Bielsa, Alba ; Gracia‐Cazaña, Tamara ; Almagro, Manuel ; De‐la‐Fuente‐Meira, Sonia ; Florez, Ángeles ; Yélamos, Oriol ; Montero‐Vilchez, Trinidad ; González‐Cruz, Carlos ; Diago, Adrián ; Abadías‐Granado, Isabel ; Fuentelsaz, Victoria ; Colmenero, María ; Bañuls, Jose ; Arias‐Santiago, Salvador ; Buendía‐Eisman, Agustín ; Almenara‐Blasco, Manuel ; Gil‐Pallares, Pedro ; Gilaberte, Yolanda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3486-b7a5431951ac3db05700459b4d5a6f52846039dd4213877125f86f9f1fe143a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Angiotensin-converting enzyme inhibitors</topic><topic>Basal cell carcinoma</topic><topic>Cancer</topic><topic>Case studies</topic><topic>Coffee</topic><topic>Dietary intake</topic><topic>Exposure</topic><topic>Hydrochlorothiazide</topic><topic>Linolenic acid</topic><topic>Multivariate analysis</topic><topic>Occupational exposure</topic><topic>Omeprazole</topic><topic>Population studies</topic><topic>Skin cancer</topic><topic>Statins</topic><topic>Statistical analysis</topic><topic>Sun</topic><topic>Ultraviolet radiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Navarro‐Bielsa, Alba</creatorcontrib><creatorcontrib>Gracia‐Cazaña, Tamara</creatorcontrib><creatorcontrib>Almagro, Manuel</creatorcontrib><creatorcontrib>De‐la‐Fuente‐Meira, Sonia</creatorcontrib><creatorcontrib>Florez, Ángeles</creatorcontrib><creatorcontrib>Yélamos, Oriol</creatorcontrib><creatorcontrib>Montero‐Vilchez, Trinidad</creatorcontrib><creatorcontrib>González‐Cruz, Carlos</creatorcontrib><creatorcontrib>Diago, Adrián</creatorcontrib><creatorcontrib>Abadías‐Granado, Isabel</creatorcontrib><creatorcontrib>Fuentelsaz, Victoria</creatorcontrib><creatorcontrib>Colmenero, María</creatorcontrib><creatorcontrib>Bañuls, Jose</creatorcontrib><creatorcontrib>Arias‐Santiago, Salvador</creatorcontrib><creatorcontrib>Buendía‐Eisman, Agustín</creatorcontrib><creatorcontrib>Almenara‐Blasco, Manuel</creatorcontrib><creatorcontrib>Gil‐Pallares, Pedro</creatorcontrib><creatorcontrib>Gilaberte, Yolanda</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Navarro‐Bielsa, Alba</au><au>Gracia‐Cazaña, Tamara</au><au>Almagro, Manuel</au><au>De‐la‐Fuente‐Meira, Sonia</au><au>Florez, Ángeles</au><au>Yélamos, Oriol</au><au>Montero‐Vilchez, Trinidad</au><au>González‐Cruz, Carlos</au><au>Diago, Adrián</au><au>Abadías‐Granado, Isabel</au><au>Fuentelsaz, Victoria</au><au>Colmenero, María</au><au>Bañuls, Jose</au><au>Arias‐Santiago, Salvador</au><au>Buendía‐Eisman, Agustín</au><au>Almenara‐Blasco, Manuel</au><au>Gil‐Pallares, Pedro</au><au>Gilaberte, Yolanda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposome and basal cell carcinoma: a multicenter case–control study</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2024-07</date><risdate>2024</risdate><volume>63</volume><issue>7</issue><spage>907</spage><epage>915</epage><pages>907-915</pages><issn>0011-9059</issn><issn>1365-4632</issn><eissn>1365-4632</eissn><abstract>Background
While ultraviolet radiation (UVR) present in sunlight is recognized as the main etiological agent of skin cancer, the most frequent form of which is basal cell carcinoma (BCC), other exposome factors like pollution, diet, and lifestyle may also contribute. This study aimed to investigate the association of BCC and exposome‐related factors in the Spanish population.
Methods
BCC cases (n = 119) and controls (n = 127) with no history of skin cancer were recruited between April 2020 and August 2022 by 13 dermatologists throughout Spain in this prospective multicenter case–control study.
Results
The BCC group had a higher proportion of outdoor workers, more years of UVR exposure, and a greater consumption of drugs (statins, ASA, hydrochlorothiazide, ACE inhibitors and omeprazole), P < 0.05. Avoidance of sun exposure was the most used photoprotection measure in both groups. The use of hats or caps was higher in the BCC group (P = 0.01). The solar protection factor (SPF) used 15 years previously was higher in the control group (P = 0.04). The control group had a higher daily screen time (P < 0.001), and practiced more relaxation activities (P = 0.03). Higher linolenic acid intake and lower coffee consumption were the only dietary variables associated with BCC (P < 0.05). Statistical significance for all the aforementioned variables was maintained in the multivariate analysis (P < 0.05).
Conclusions
The study found a significant association between BCC and multiple exposome‐related factors in addition to chronic sun exposure in the Spanish population. Primary prevention strategies should target specific populations, such as outdoor workers, promoting sun‐safe behaviors and stress‐reducing activities, and also adequate skin photoprotection in patients on certain medications associated with increased BCC risk.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>38282244</pmid><doi>10.1111/ijd.17026</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4035-7955</orcidid><orcidid>https://orcid.org/0000-0003-1171-6007</orcidid><orcidid>https://orcid.org/0000-0001-8469-1942</orcidid><orcidid>https://orcid.org/0000-0002-4350-401X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Angiotensin-converting enzyme inhibitors Basal cell carcinoma Cancer Case studies Coffee Dietary intake Exposure Hydrochlorothiazide Linolenic acid Multivariate analysis Occupational exposure Omeprazole Population studies Skin cancer Statins Statistical analysis Sun Ultraviolet radiation |
| title | Exposome and basal cell carcinoma: a multicenter case–control study |
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