DLC coatings: Effects of physical and chemical properties on biological response
Abstract Recent trials on diamond-like carbon (DLC) coated medical devices have indicated promise for blood interfacing applications. The literature is sparse regarding structural and compositional effects of DLC on cellular response. An important goal in optimizing blood-interfacing implants is min...
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| Veröffentlicht in: | Biomaterials 2007-03, Vol.28 (9), p.1620-1628 |
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| creator | Ma, Wen J Ruys, Andrew J Mason, Rebecca S Martin, Phil J Bendavid, Avi Liu, Zongwen Ionescu, Mihail Zreiqat, Hala |
| description | Abstract Recent trials on diamond-like carbon (DLC) coated medical devices have indicated promise for blood interfacing applications. The literature is sparse regarding structural and compositional effects of DLC on cellular response. An important goal in optimizing blood-interfacing implants is minimal macrophage attachment, and maximal albumin:fibrinogen adsorption ratio. DLC coatings deposited by PACVD and FAD, were analysed with respect to sp3 content (EELS), hydrogen content (ERDA), surface composition (XPS), surface roughness (AFM), surface energy, albumin:fibrinogen adsorption ratio, and macrophage viability and attachment. We found that increasing surface roughness and surface energy enhanced the macrophage viability and the albumin:fibrinogen adsorption ratio. We also found that the higher the hydrogen content for a-C:Hs deposited by PACVD, the lower the albumin:fibrinogen adsorption ratio, and macrophage attachment. This suggests that hydrogen content may be an important factor for influencing the biological response of DLC surfaces. Macrophage cells spread well on all DLC surfaces, and the surface results indicated the non-toxic nature of the surfaces on the cells at the time points tested. |
| doi_str_mv | 10.1016/j.biomaterials.2006.12.010 |
| format | Article |
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The literature is sparse regarding structural and compositional effects of DLC on cellular response. An important goal in optimizing blood-interfacing implants is minimal macrophage attachment, and maximal albumin:fibrinogen adsorption ratio. DLC coatings deposited by PACVD and FAD, were analysed with respect to sp3 content (EELS), hydrogen content (ERDA), surface composition (XPS), surface roughness (AFM), surface energy, albumin:fibrinogen adsorption ratio, and macrophage viability and attachment. We found that increasing surface roughness and surface energy enhanced the macrophage viability and the albumin:fibrinogen adsorption ratio. We also found that the higher the hydrogen content for a-C:Hs deposited by PACVD, the lower the albumin:fibrinogen adsorption ratio, and macrophage attachment. This suggests that hydrogen content may be an important factor for influencing the biological response of DLC surfaces. Macrophage cells spread well on all DLC surfaces, and the surface results indicated the non-toxic nature of the surfaces on the cells at the time points tested.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2006.12.010</identifier><identifier>PMID: 17196649</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Amorphous carbon ; Animals ; Biocompatibility ; Cell Line ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Coated Materials, Biocompatible - chemistry ; Coated Materials, Biocompatible - pharmacology ; Dentistry ; Diamond - chemistry ; Diamond - pharmacology ; Hydrogen content ; Macrophage ; Macrophage Activation - drug effects ; Macrophages - cytology ; Macrophages - drug effects ; Materials Testing ; Mice ; Protein ; Surface energy ; Surface Properties</subject><ispartof>Biomaterials, 2007-03, Vol.28 (9), p.1620-1628</ispartof><rights>Elsevier Ltd</rights><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-8c4daf42b396f94c8da6f5d2af1c0701abc93c10f753fed3c9a8d09b2887153a3</citedby><cites>FETCH-LOGICAL-c561t-8c4daf42b396f94c8da6f5d2af1c0701abc93c10f753fed3c9a8d09b2887153a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2006.12.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17196649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Wen J</creatorcontrib><creatorcontrib>Ruys, Andrew J</creatorcontrib><creatorcontrib>Mason, Rebecca S</creatorcontrib><creatorcontrib>Martin, Phil J</creatorcontrib><creatorcontrib>Bendavid, Avi</creatorcontrib><creatorcontrib>Liu, Zongwen</creatorcontrib><creatorcontrib>Ionescu, Mihail</creatorcontrib><creatorcontrib>Zreiqat, Hala</creatorcontrib><title>DLC coatings: Effects of physical and chemical properties on biological response</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Abstract Recent trials on diamond-like carbon (DLC) coated medical devices have indicated promise for blood interfacing applications. The literature is sparse regarding structural and compositional effects of DLC on cellular response. An important goal in optimizing blood-interfacing implants is minimal macrophage attachment, and maximal albumin:fibrinogen adsorption ratio. DLC coatings deposited by PACVD and FAD, were analysed with respect to sp3 content (EELS), hydrogen content (ERDA), surface composition (XPS), surface roughness (AFM), surface energy, albumin:fibrinogen adsorption ratio, and macrophage viability and attachment. We found that increasing surface roughness and surface energy enhanced the macrophage viability and the albumin:fibrinogen adsorption ratio. We also found that the higher the hydrogen content for a-C:Hs deposited by PACVD, the lower the albumin:fibrinogen adsorption ratio, and macrophage attachment. This suggests that hydrogen content may be an important factor for influencing the biological response of DLC surfaces. Macrophage cells spread well on all DLC surfaces, and the surface results indicated the non-toxic nature of the surfaces on the cells at the time points tested.</description><subject>Advanced Basic Science</subject><subject>Amorphous carbon</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Cell Line</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Coated Materials, Biocompatible - pharmacology</subject><subject>Dentistry</subject><subject>Diamond - chemistry</subject><subject>Diamond - pharmacology</subject><subject>Hydrogen content</subject><subject>Macrophage</subject><subject>Macrophage Activation - drug effects</subject><subject>Macrophages - cytology</subject><subject>Macrophages - drug effects</subject><subject>Materials Testing</subject><subject>Mice</subject><subject>Protein</subject><subject>Surface energy</subject><subject>Surface Properties</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl-L1DAUxYMo7rj6FaT44FtrbtomzT4IMrv-gQEF9Tmkyc1uxrapSWdhvr3pzoDiiz6FS8659_C7l5BXQCugwN_sq96HUS8YvR5SxSjlFbCKAn1ENtCJrmwlbR-TDYWGlZIDuyDPUtrTXNOGPSUXIEBy3sgN-XK92xYm6MVPt-mquHEOzZKK4Ir57pi80UOhJ1uYOxwfijmGGePiMWumIucYwu3DR8Q0hynhc_LE5VT44vxeku_vb75tP5a7zx8-bd_tStNyWMrONFa7hvW15E42prOau9Yy7cBQQUH3RtYGqBNt7dDWRurOUtmzrhPQ1rq-JK9PfXOinwdMixp9MjgMesJwSIpJkI0A8U8hSEFb2jVZeHUSmhhSiujUHP2o41EBVSt4tVd_glcreAVMZfDZ_PI85dCPaH9bz6Sz4PokwAzl3mNUyXicDFofM3Jlg_-_OW__amMGP60b-IFHTPtwiNPqAZWyQX1dT2C9AMqzG4SsfwEhPLCL</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Ma, Wen J</creator><creator>Ruys, Andrew J</creator><creator>Mason, Rebecca S</creator><creator>Martin, Phil J</creator><creator>Bendavid, Avi</creator><creator>Liu, Zongwen</creator><creator>Ionescu, Mihail</creator><creator>Zreiqat, Hala</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20070301</creationdate><title>DLC coatings: Effects of physical and chemical properties on biological response</title><author>Ma, Wen J ; Ruys, Andrew J ; Mason, Rebecca S ; Martin, Phil J ; Bendavid, Avi ; Liu, Zongwen ; Ionescu, Mihail ; Zreiqat, Hala</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-8c4daf42b396f94c8da6f5d2af1c0701abc93c10f753fed3c9a8d09b2887153a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Advanced Basic Science</topic><topic>Amorphous carbon</topic><topic>Animals</topic><topic>Biocompatibility</topic><topic>Cell Line</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Coated Materials, Biocompatible - pharmacology</topic><topic>Dentistry</topic><topic>Diamond - chemistry</topic><topic>Diamond - pharmacology</topic><topic>Hydrogen content</topic><topic>Macrophage</topic><topic>Macrophage Activation - drug effects</topic><topic>Macrophages - cytology</topic><topic>Macrophages - drug effects</topic><topic>Materials Testing</topic><topic>Mice</topic><topic>Protein</topic><topic>Surface energy</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Wen J</creatorcontrib><creatorcontrib>Ruys, Andrew J</creatorcontrib><creatorcontrib>Mason, Rebecca S</creatorcontrib><creatorcontrib>Martin, Phil J</creatorcontrib><creatorcontrib>Bendavid, Avi</creatorcontrib><creatorcontrib>Liu, Zongwen</creatorcontrib><creatorcontrib>Ionescu, Mihail</creatorcontrib><creatorcontrib>Zreiqat, Hala</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Wen J</au><au>Ruys, Andrew J</au><au>Mason, Rebecca S</au><au>Martin, Phil J</au><au>Bendavid, Avi</au><au>Liu, Zongwen</au><au>Ionescu, Mihail</au><au>Zreiqat, Hala</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DLC coatings: Effects of physical and chemical properties on biological response</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>28</volume><issue>9</issue><spage>1620</spage><epage>1628</epage><pages>1620-1628</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Abstract Recent trials on diamond-like carbon (DLC) coated medical devices have indicated promise for blood interfacing applications. The literature is sparse regarding structural and compositional effects of DLC on cellular response. An important goal in optimizing blood-interfacing implants is minimal macrophage attachment, and maximal albumin:fibrinogen adsorption ratio. DLC coatings deposited by PACVD and FAD, were analysed with respect to sp3 content (EELS), hydrogen content (ERDA), surface composition (XPS), surface roughness (AFM), surface energy, albumin:fibrinogen adsorption ratio, and macrophage viability and attachment. We found that increasing surface roughness and surface energy enhanced the macrophage viability and the albumin:fibrinogen adsorption ratio. We also found that the higher the hydrogen content for a-C:Hs deposited by PACVD, the lower the albumin:fibrinogen adsorption ratio, and macrophage attachment. This suggests that hydrogen content may be an important factor for influencing the biological response of DLC surfaces. Macrophage cells spread well on all DLC surfaces, and the surface results indicated the non-toxic nature of the surfaces on the cells at the time points tested.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>17196649</pmid><doi>10.1016/j.biomaterials.2006.12.010</doi><tpages>9</tpages></addata></record> |
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| subjects | Advanced Basic Science Amorphous carbon Animals Biocompatibility Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology Dentistry Diamond - chemistry Diamond - pharmacology Hydrogen content Macrophage Macrophage Activation - drug effects Macrophages - cytology Macrophages - drug effects Materials Testing Mice Protein Surface energy Surface Properties |
| title | DLC coatings: Effects of physical and chemical properties on biological response |
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