Monitoring polysorbate 80 degradation in protein solutions using Total Holographic Characterization

[Display omitted] •Detect distinguish and quantify oleic acid from lipase induced degradation of PS80.•Simultaneously detect and distinguish oleic acid, protein aggregates and silicone oil.•Detection of oleic acid at concentrations less than 100 ng/mL.•Protein solutions in which PS80 has been degrad...

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Veröffentlicht in:	International journal of pharmaceutics 2024-03, Vol.652, p.123843-123843, Article 123843
Hauptverfasser:	Markus, Tiffany, Lumer, Juliana, Stasavage, Rivka, Ruffner, David B., Philips, Laura A., Cheong, Fook Chiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopharmaceutical Characterization Degradation products Protein aggregation Stability Surfactant
Online-Zugang:	Volltext
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