Pesticide use patterns and their association with cytokine levels in Mexican flower workers
Objective Occupational exposure to pesticides is a known risk for disrupting cellular immune response in flower workers due to their use of multiple chemical products, poor work conditions, and inadequate protection. Recently, the analysis of pesticide use patterns has emerged as an alternative to s...
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| Veröffentlicht in: | International archives of occupational and environmental health 2024-04, Vol.97 (3), p.291-302 |
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| creator | Godínez-Pérez, Brenda Mélany Schilmann, Astrid Lagunas-Martínez, Alfredo Escamilla-Núñez, Consuelo Burguete-García, Ana Isabel Aguilar-Garduño, Clemente Blanco-Muñoz, Julia Lacasaña, Marina |
| description | Objective
Occupational exposure to pesticides is a known risk for disrupting cellular immune response in flower workers due to their use of multiple chemical products, poor work conditions, and inadequate protection. Recently, the analysis of pesticide use patterns has emerged as an alternative to studying exposure to mixtures of these products. This study aimed to evaluate the association between exposure to different patterns of pesticide use and the cytokine profile of flower workers in the State of Mexico and Morelos, Mexico.
Methods
A cross-sectional study was carried out on a population of 108 flower workers. Serum levels of IL-4, IL-5, IL-6, IL-8, IL-10 cytokines were analyzed by means of multiplex analysis, and TNF-α and IFN-γ using an ELISA test. Pesticide use patterns were generated by principal components analysis.
Results
The analysis revealed that certain patterns of pesticide use, combining insecticides and fungicides, were associated with higher levels of pro-inflammatory cytokines, particularly IL-6 and IFN-γ.
Conclusion
These findings indicate that pesticides may possess immunotoxic properties, contributing to increased inflammatory response. However, further comprehensive epidemiological studies are needed to establish a causal relationship. |
| doi_str_mv | 10.1007/s00420-023-02043-x |
| format | Article |
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Occupational exposure to pesticides is a known risk for disrupting cellular immune response in flower workers due to their use of multiple chemical products, poor work conditions, and inadequate protection. Recently, the analysis of pesticide use patterns has emerged as an alternative to studying exposure to mixtures of these products. This study aimed to evaluate the association between exposure to different patterns of pesticide use and the cytokine profile of flower workers in the State of Mexico and Morelos, Mexico.
Methods
A cross-sectional study was carried out on a population of 108 flower workers. Serum levels of IL-4, IL-5, IL-6, IL-8, IL-10 cytokines were analyzed by means of multiplex analysis, and TNF-α and IFN-γ using an ELISA test. Pesticide use patterns were generated by principal components analysis.
Results
The analysis revealed that certain patterns of pesticide use, combining insecticides and fungicides, were associated with higher levels of pro-inflammatory cytokines, particularly IL-6 and IFN-γ.
Conclusion
These findings indicate that pesticides may possess immunotoxic properties, contributing to increased inflammatory response. However, further comprehensive epidemiological studies are needed to establish a causal relationship.</description><identifier>ISSN: 0340-0131</identifier><identifier>EISSN: 1432-1246</identifier><identifier>DOI: 10.1007/s00420-023-02043-x</identifier><identifier>PMID: 38270603</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cross-Sectional Studies ; Cytokines ; Earth and Environmental Science ; Environment ; Environmental Health ; Enzyme-linked immunosorbent assay ; Epidemiology ; Exposure ; Flowers ; Flowers - chemistry ; Fungicides ; Humans ; Immune response ; Immune response (cell-mediated) ; Immune system ; Inflammation ; Inflammatory response ; Insecticides ; Interleukin 6 ; Mexico - epidemiology ; Occupational exposure ; Occupational Exposure - adverse effects ; Occupational Exposure - analysis ; Occupational health ; Occupational Medicine/Industrial Medicine ; Original Article ; Pesticides ; Pesticides - toxicity ; Principal components analysis ; Rehabilitation ; Serum levels ; Tumor necrosis factor-α ; Working conditions ; γ-Interferon</subject><ispartof>International archives of occupational and environmental health, 2024-04, Vol.97 (3), p.291-302</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-b67a1c4efa09e87daa8bcf82b09165d34fc087ef8a174cba406098d38b003c213</cites><orcidid>0000-0002-3352-8632</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00420-023-02043-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00420-023-02043-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38270603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Godínez-Pérez, Brenda Mélany</creatorcontrib><creatorcontrib>Schilmann, Astrid</creatorcontrib><creatorcontrib>Lagunas-Martínez, Alfredo</creatorcontrib><creatorcontrib>Escamilla-Núñez, Consuelo</creatorcontrib><creatorcontrib>Burguete-García, Ana Isabel</creatorcontrib><creatorcontrib>Aguilar-Garduño, Clemente</creatorcontrib><creatorcontrib>Blanco-Muñoz, Julia</creatorcontrib><creatorcontrib>Lacasaña, Marina</creatorcontrib><title>Pesticide use patterns and their association with cytokine levels in Mexican flower workers</title><title>International archives of occupational and environmental health</title><addtitle>Int Arch Occup Environ Health</addtitle><addtitle>Int Arch Occup Environ Health</addtitle><description>Objective
Occupational exposure to pesticides is a known risk for disrupting cellular immune response in flower workers due to their use of multiple chemical products, poor work conditions, and inadequate protection. Recently, the analysis of pesticide use patterns has emerged as an alternative to studying exposure to mixtures of these products. This study aimed to evaluate the association between exposure to different patterns of pesticide use and the cytokine profile of flower workers in the State of Mexico and Morelos, Mexico.
Methods
A cross-sectional study was carried out on a population of 108 flower workers. Serum levels of IL-4, IL-5, IL-6, IL-8, IL-10 cytokines were analyzed by means of multiplex analysis, and TNF-α and IFN-γ using an ELISA test. Pesticide use patterns were generated by principal components analysis.
Results
The analysis revealed that certain patterns of pesticide use, combining insecticides and fungicides, were associated with higher levels of pro-inflammatory cytokines, particularly IL-6 and IFN-γ.
Conclusion
These findings indicate that pesticides may possess immunotoxic properties, contributing to increased inflammatory response. However, further comprehensive epidemiological studies are needed to establish a causal relationship.</description><subject>Cross-Sectional Studies</subject><subject>Cytokines</subject><subject>Earth and Environmental Science</subject><subject>Environment</subject><subject>Environmental Health</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Flowers</subject><subject>Flowers - chemistry</subject><subject>Fungicides</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune response (cell-mediated)</subject><subject>Immune system</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Insecticides</subject><subject>Interleukin 6</subject><subject>Mexico - epidemiology</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational Exposure - analysis</subject><subject>Occupational health</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Pesticides</subject><subject>Pesticides - toxicity</subject><subject>Principal components analysis</subject><subject>Rehabilitation</subject><subject>Serum levels</subject><subject>Tumor necrosis factor-α</subject><subject>Working conditions</subject><subject>γ-Interferon</subject><issn>0340-0131</issn><issn>1432-1246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PHDEQhq0IBAfhD6RAltLQLIw_bu0tI0QACQQFqVJYXu9sMOzZF3s3d_x7HI4QiYJi5GKeeWf8EPKFwTEDUCcZQHKogItSIEW1_kRmTApeMS7rLTIDIUubCbZL9nJ-AGCqVmKH7ArNFdQgZuTnLebRO98hnTLSpR1HTCFTGzo63qNP1OYcnbejj4Gu_HhP3dMYH31AOuAfHDL1gV7j2jsbaD_EFSa6iukRU_5Mtns7ZDx4fffJj-9nd6cX1dXN-eXpt6vKCV6PVVsry5zE3kKDWnXW6tb1mrfQsHreCdk70Ap7bZmSrrWyXN7oTugWQDjOxD452uQuU_w9lf-Yhc8Oh8EGjFM2vGF6XpS8oF_foQ9xSqFcV6i5ZqwWjSoU31AuxZwT9maZ_MKmJ8PA_FVvNupNUW9e1Jt1GTp8jZ7aBXZvI_9cF0BsgFxa4Rem_7s_iH0GsVaPpA</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Godínez-Pérez, Brenda Mélany</creator><creator>Schilmann, Astrid</creator><creator>Lagunas-Martínez, Alfredo</creator><creator>Escamilla-Núñez, Consuelo</creator><creator>Burguete-García, Ana Isabel</creator><creator>Aguilar-Garduño, Clemente</creator><creator>Blanco-Muñoz, Julia</creator><creator>Lacasaña, Marina</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3352-8632</orcidid></search><sort><creationdate>20240401</creationdate><title>Pesticide use patterns and their association with cytokine levels in Mexican flower workers</title><author>Godínez-Pérez, Brenda Mélany ; Schilmann, Astrid ; Lagunas-Martínez, Alfredo ; Escamilla-Núñez, Consuelo ; Burguete-García, Ana Isabel ; Aguilar-Garduño, Clemente ; Blanco-Muñoz, Julia ; Lacasaña, Marina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-b67a1c4efa09e87daa8bcf82b09165d34fc087ef8a174cba406098d38b003c213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cross-Sectional Studies</topic><topic>Cytokines</topic><topic>Earth and Environmental Science</topic><topic>Environment</topic><topic>Environmental Health</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Epidemiology</topic><topic>Exposure</topic><topic>Flowers</topic><topic>Flowers - chemistry</topic><topic>Fungicides</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune response (cell-mediated)</topic><topic>Immune system</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Insecticides</topic><topic>Interleukin 6</topic><topic>Mexico - epidemiology</topic><topic>Occupational exposure</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational Exposure - analysis</topic><topic>Occupational health</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Pesticides</topic><topic>Pesticides - toxicity</topic><topic>Principal components analysis</topic><topic>Rehabilitation</topic><topic>Serum levels</topic><topic>Tumor necrosis factor-α</topic><topic>Working conditions</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Godínez-Pérez, Brenda Mélany</creatorcontrib><creatorcontrib>Schilmann, Astrid</creatorcontrib><creatorcontrib>Lagunas-Martínez, Alfredo</creatorcontrib><creatorcontrib>Escamilla-Núñez, Consuelo</creatorcontrib><creatorcontrib>Burguete-García, Ana Isabel</creatorcontrib><creatorcontrib>Aguilar-Garduño, Clemente</creatorcontrib><creatorcontrib>Blanco-Muñoz, Julia</creatorcontrib><creatorcontrib>Lacasaña, Marina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International archives of occupational and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Godínez-Pérez, Brenda Mélany</au><au>Schilmann, Astrid</au><au>Lagunas-Martínez, Alfredo</au><au>Escamilla-Núñez, Consuelo</au><au>Burguete-García, Ana Isabel</au><au>Aguilar-Garduño, Clemente</au><au>Blanco-Muñoz, Julia</au><au>Lacasaña, Marina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pesticide use patterns and their association with cytokine levels in Mexican flower workers</atitle><jtitle>International archives of occupational and environmental health</jtitle><stitle>Int Arch Occup Environ Health</stitle><addtitle>Int Arch Occup Environ Health</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>97</volume><issue>3</issue><spage>291</spage><epage>302</epage><pages>291-302</pages><issn>0340-0131</issn><eissn>1432-1246</eissn><abstract>Objective
Occupational exposure to pesticides is a known risk for disrupting cellular immune response in flower workers due to their use of multiple chemical products, poor work conditions, and inadequate protection. Recently, the analysis of pesticide use patterns has emerged as an alternative to studying exposure to mixtures of these products. This study aimed to evaluate the association between exposure to different patterns of pesticide use and the cytokine profile of flower workers in the State of Mexico and Morelos, Mexico.
Methods
A cross-sectional study was carried out on a population of 108 flower workers. Serum levels of IL-4, IL-5, IL-6, IL-8, IL-10 cytokines were analyzed by means of multiplex analysis, and TNF-α and IFN-γ using an ELISA test. Pesticide use patterns were generated by principal components analysis.
Results
The analysis revealed that certain patterns of pesticide use, combining insecticides and fungicides, were associated with higher levels of pro-inflammatory cytokines, particularly IL-6 and IFN-γ.
Conclusion
These findings indicate that pesticides may possess immunotoxic properties, contributing to increased inflammatory response. However, further comprehensive epidemiological studies are needed to establish a causal relationship.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38270603</pmid><doi>10.1007/s00420-023-02043-x</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-3352-8632</orcidid></addata></record> |
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| subjects | Cross-Sectional Studies Cytokines Earth and Environmental Science Environment Environmental Health Enzyme-linked immunosorbent assay Epidemiology Exposure Flowers Flowers - chemistry Fungicides Humans Immune response Immune response (cell-mediated) Immune system Inflammation Inflammatory response Insecticides Interleukin 6 Mexico - epidemiology Occupational exposure Occupational Exposure - adverse effects Occupational Exposure - analysis Occupational health Occupational Medicine/Industrial Medicine Original Article Pesticides Pesticides - toxicity Principal components analysis Rehabilitation Serum levels Tumor necrosis factor-α Working conditions γ-Interferon |
| title | Pesticide use patterns and their association with cytokine levels in Mexican flower workers |
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