Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases

While progress has been made in the effort to eradicate malaria, the disease remains a significant threat to global health. Acquired resistance to frontline treatments is emerging in Africa, urging a need for the development of novel antimalarial agents. Repurposing human kinase inhibitors provides...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-01, Vol.67 (2), p.1460-1480
Hauptverfasser:	Wang, Lushun, Bohmer, Monica J., Wang, Jinhua, Nardella, Flore, Calla, Jaeson, Laureano De Souza, Mariana, Schindler, Kyra A., Montejo, Lukas, Mittal, Nimisha, Rocamora, Frances, Treat, Mayland, Charlton, Jordan T., Tumwebaze, Patrick K., Rosenthal, Philip J., Cooper, Roland A., Chakrabarti, Ratna, Winzeler, Elizabeth A., Chakrabarti, Debopam, Gray, Nathanael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa Antimalarials - pharmacology Antimalarials - therapeutic use Humans Malaria - drug therapy Plasmodium falciparum Receptor, EphA2 Structure-Activity Relationship
Online-Zugang:	Volltext
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