Physical and psychosocial outcomes among burn-injured people with heterotopic ossification: A burn model system study
Heterotopic ossification (HO), or ectopic bone formation in soft tissue, is a not so rare and poorly understood debilitating sequela of burn injury. Individuals developing HO following burn injuries to their hands often experience reductions in mobility, significant contractures, and joint pain. Thi...
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| Veröffentlicht in: | Burns 2024-05, Vol.50 (4), p.957-965 |
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| creator | Won, Paul Pickering, Trevor A. Schneider, Jeffrey C. Kowalske, Karen Ryan, Colleen M. Carrougher, Gretchen J. Stewart, Barclay T. Yenikomshian, Haig A. |
| description | Heterotopic ossification (HO), or ectopic bone formation in soft tissue, is a not so rare and poorly understood debilitating sequela of burn injury. Individuals developing HO following burn injuries to their hands often experience reductions in mobility, significant contractures, and joint pain. This study identifies demographic characteristics of individuals who develop HO and compares their physical and psychosocial outcomes to the general burn population.
Participant demographics, injury characteristics, and PROMIS-29 scores across three time points (discharge, six- and 12- months after injury) were extracted from the Burn Model System National Longitudinal Database representing participants from 2015–2022. Mixed-effects linear regression models were used to compare PROMIS scores across all three longitudinal measurements. Models were adjusted for age, sex, race/ethnicity, HO status, and burn size.
Of the 861 participants with data concerning HO, 33 were diagnosed with HO (3.8% of participants). Most participants with HO were male (n = 24, 73%) and had an average age of 40 + /− 13 years. Participants with HO had significantly larger burn size (49 +/−23% Total Body Surface Area (TBSA)) than those without HO (16 +/−17%). Participants with HO reported significantly worse physical function, depression, pain interference and social integration scores than those without HO. After adjusting for covariables, participants with HO continued to report statistically significantly worse physical function than those without HO. Although physical functioning was consistently lower, the two populations did not differ significantly among psychosocial outcome measures.
While HO can result in physical limitations, the translation to psychosocial impairments was not evident. Targeted treatment of HO with the goal of maximizing physical function should be a focus of their rehabilitation.
2b
Symptom Prevalence Study
•Those with heterotopic ossification (HO) had larger burn sizes than those without.•This study highlights physical limitations that burn patients with HO face.•Those with HO do not report worse psychosocial outcomes than those without. |
| doi_str_mv | 10.1016/j.burns.2024.01.017 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2918511511</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0305417924000202</els_id><sourcerecordid>2918511511</sourcerecordid><originalsourceid>FETCH-LOGICAL-c309t-51319c6522839b50456a81f314074ea929f77e6b5b089b459de5dc6f12c1f2ca3</originalsourceid><addsrcrecordid>eNp9UNGK1TAQDeLiXle_QJA8-tJrJm3aRvBhWXZVWFgf9Dmk6dSbS9vUTKr0783du_rocGBgOGcO5zD2BsQeBNTvj_tujTPtpZDVXkBG84ztoG10AZXQz9lOlEIVFTT6kr0kOoo8qhUv2GXZyrqRrd6x9ethI-_syO3c84U2dwgUnM-HsCYXJiRupzD_4Cezws_HNWImYlhG5L99OvADJowhhcU7Hoj8kN8lH-YP_PpRxKfQ48hpo4QTp7T22yt2MdiR8PXTvmLf726_3Xwu7h8-fbm5vi9cKXQqFJSgXa2kbEvdKVGp2rYwlDleU6HVUg9Ng3WnOtHqrlK6R9W7egDpYJDOllfs3fnvEsPPFSmZyZPDcbQzhpWM1NAqgIxMLc9UF3OIiINZop9s3AwIc-rbHM1j3-bUtxGQ0WTV2yeDtZuw_6f5W3AmfDwTMMf85TEach5nh72P6JLpg_-vwR_vmZRT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918511511</pqid></control><display><type>article</type><title>Physical and psychosocial outcomes among burn-injured people with heterotopic ossification: A burn model system study</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Won, Paul ; Pickering, Trevor A. ; Schneider, Jeffrey C. ; Kowalske, Karen ; Ryan, Colleen M. ; Carrougher, Gretchen J. ; Stewart, Barclay T. ; Yenikomshian, Haig A.</creator><creatorcontrib>Won, Paul ; Pickering, Trevor A. ; Schneider, Jeffrey C. ; Kowalske, Karen ; Ryan, Colleen M. ; Carrougher, Gretchen J. ; Stewart, Barclay T. ; Yenikomshian, Haig A.</creatorcontrib><description>Heterotopic ossification (HO), or ectopic bone formation in soft tissue, is a not so rare and poorly understood debilitating sequela of burn injury. Individuals developing HO following burn injuries to their hands often experience reductions in mobility, significant contractures, and joint pain. This study identifies demographic characteristics of individuals who develop HO and compares their physical and psychosocial outcomes to the general burn population.
Participant demographics, injury characteristics, and PROMIS-29 scores across three time points (discharge, six- and 12- months after injury) were extracted from the Burn Model System National Longitudinal Database representing participants from 2015–2022. Mixed-effects linear regression models were used to compare PROMIS scores across all three longitudinal measurements. Models were adjusted for age, sex, race/ethnicity, HO status, and burn size.
Of the 861 participants with data concerning HO, 33 were diagnosed with HO (3.8% of participants). Most participants with HO were male (n = 24, 73%) and had an average age of 40 + /− 13 years. Participants with HO had significantly larger burn size (49 +/−23% Total Body Surface Area (TBSA)) than those without HO (16 +/−17%). Participants with HO reported significantly worse physical function, depression, pain interference and social integration scores than those without HO. After adjusting for covariables, participants with HO continued to report statistically significantly worse physical function than those without HO. Although physical functioning was consistently lower, the two populations did not differ significantly among psychosocial outcome measures.
While HO can result in physical limitations, the translation to psychosocial impairments was not evident. Targeted treatment of HO with the goal of maximizing physical function should be a focus of their rehabilitation.
2b
Symptom Prevalence Study
•Those with heterotopic ossification (HO) had larger burn sizes than those without.•This study highlights physical limitations that burn patients with HO face.•Those with HO do not report worse psychosocial outcomes than those without.</description><identifier>ISSN: 0305-4179</identifier><identifier>ISSN: 1879-1409</identifier><identifier>EISSN: 1879-1409</identifier><identifier>DOI: 10.1016/j.burns.2024.01.017</identifier><identifier>PMID: 38267289</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Burns - complications ; Burns - psychology ; Burns outcomes ; Female ; Heterotopic ossification ; Humans ; Linear Models ; Longitudinal Studies ; Male ; Middle Aged ; Ossification, Heterotopic - etiology ; Ossification, Heterotopic - psychology ; PROMIS-29 ; Quality of Life ; Recovery</subject><ispartof>Burns, 2024-05, Vol.50 (4), p.957-965</ispartof><rights>2024 Elsevier Ltd and International Society of Burns Injuries</rights><rights>Copyright © 2024 Elsevier Ltd and International Society of Burns Injuries. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c309t-51319c6522839b50456a81f314074ea929f77e6b5b089b459de5dc6f12c1f2ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0305417924000202$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38267289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Won, Paul</creatorcontrib><creatorcontrib>Pickering, Trevor A.</creatorcontrib><creatorcontrib>Schneider, Jeffrey C.</creatorcontrib><creatorcontrib>Kowalske, Karen</creatorcontrib><creatorcontrib>Ryan, Colleen M.</creatorcontrib><creatorcontrib>Carrougher, Gretchen J.</creatorcontrib><creatorcontrib>Stewart, Barclay T.</creatorcontrib><creatorcontrib>Yenikomshian, Haig A.</creatorcontrib><title>Physical and psychosocial outcomes among burn-injured people with heterotopic ossification: A burn model system study</title><title>Burns</title><addtitle>Burns</addtitle><description>Heterotopic ossification (HO), or ectopic bone formation in soft tissue, is a not so rare and poorly understood debilitating sequela of burn injury. Individuals developing HO following burn injuries to their hands often experience reductions in mobility, significant contractures, and joint pain. This study identifies demographic characteristics of individuals who develop HO and compares their physical and psychosocial outcomes to the general burn population.
Participant demographics, injury characteristics, and PROMIS-29 scores across three time points (discharge, six- and 12- months after injury) were extracted from the Burn Model System National Longitudinal Database representing participants from 2015–2022. Mixed-effects linear regression models were used to compare PROMIS scores across all three longitudinal measurements. Models were adjusted for age, sex, race/ethnicity, HO status, and burn size.
Of the 861 participants with data concerning HO, 33 were diagnosed with HO (3.8% of participants). Most participants with HO were male (n = 24, 73%) and had an average age of 40 + /− 13 years. Participants with HO had significantly larger burn size (49 +/−23% Total Body Surface Area (TBSA)) than those without HO (16 +/−17%). Participants with HO reported significantly worse physical function, depression, pain interference and social integration scores than those without HO. After adjusting for covariables, participants with HO continued to report statistically significantly worse physical function than those without HO. Although physical functioning was consistently lower, the two populations did not differ significantly among psychosocial outcome measures.
While HO can result in physical limitations, the translation to psychosocial impairments was not evident. Targeted treatment of HO with the goal of maximizing physical function should be a focus of their rehabilitation.
2b
Symptom Prevalence Study
•Those with heterotopic ossification (HO) had larger burn sizes than those without.•This study highlights physical limitations that burn patients with HO face.•Those with HO do not report worse psychosocial outcomes than those without.</description><subject>Adult</subject><subject>Burns - complications</subject><subject>Burns - psychology</subject><subject>Burns outcomes</subject><subject>Female</subject><subject>Heterotopic ossification</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ossification, Heterotopic - etiology</subject><subject>Ossification, Heterotopic - psychology</subject><subject>PROMIS-29</subject><subject>Quality of Life</subject><subject>Recovery</subject><issn>0305-4179</issn><issn>1879-1409</issn><issn>1879-1409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UNGK1TAQDeLiXle_QJA8-tJrJm3aRvBhWXZVWFgf9Dmk6dSbS9vUTKr0783du_rocGBgOGcO5zD2BsQeBNTvj_tujTPtpZDVXkBG84ztoG10AZXQz9lOlEIVFTT6kr0kOoo8qhUv2GXZyrqRrd6x9ethI-_syO3c84U2dwgUnM-HsCYXJiRupzD_4Cezws_HNWImYlhG5L99OvADJowhhcU7Hoj8kN8lH-YP_PpRxKfQ48hpo4QTp7T22yt2MdiR8PXTvmLf726_3Xwu7h8-fbm5vi9cKXQqFJSgXa2kbEvdKVGp2rYwlDleU6HVUg9Ng3WnOtHqrlK6R9W7egDpYJDOllfs3fnvEsPPFSmZyZPDcbQzhpWM1NAqgIxMLc9UF3OIiINZop9s3AwIc-rbHM1j3-bUtxGQ0WTV2yeDtZuw_6f5W3AmfDwTMMf85TEach5nh72P6JLpg_-vwR_vmZRT</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Won, Paul</creator><creator>Pickering, Trevor A.</creator><creator>Schneider, Jeffrey C.</creator><creator>Kowalske, Karen</creator><creator>Ryan, Colleen M.</creator><creator>Carrougher, Gretchen J.</creator><creator>Stewart, Barclay T.</creator><creator>Yenikomshian, Haig A.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202405</creationdate><title>Physical and psychosocial outcomes among burn-injured people with heterotopic ossification: A burn model system study</title><author>Won, Paul ; Pickering, Trevor A. ; Schneider, Jeffrey C. ; Kowalske, Karen ; Ryan, Colleen M. ; Carrougher, Gretchen J. ; Stewart, Barclay T. ; Yenikomshian, Haig A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-51319c6522839b50456a81f314074ea929f77e6b5b089b459de5dc6f12c1f2ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Burns - complications</topic><topic>Burns - psychology</topic><topic>Burns outcomes</topic><topic>Female</topic><topic>Heterotopic ossification</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Ossification, Heterotopic - etiology</topic><topic>Ossification, Heterotopic - psychology</topic><topic>PROMIS-29</topic><topic>Quality of Life</topic><topic>Recovery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Won, Paul</creatorcontrib><creatorcontrib>Pickering, Trevor A.</creatorcontrib><creatorcontrib>Schneider, Jeffrey C.</creatorcontrib><creatorcontrib>Kowalske, Karen</creatorcontrib><creatorcontrib>Ryan, Colleen M.</creatorcontrib><creatorcontrib>Carrougher, Gretchen J.</creatorcontrib><creatorcontrib>Stewart, Barclay T.</creatorcontrib><creatorcontrib>Yenikomshian, Haig A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Burns</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Won, Paul</au><au>Pickering, Trevor A.</au><au>Schneider, Jeffrey C.</au><au>Kowalske, Karen</au><au>Ryan, Colleen M.</au><au>Carrougher, Gretchen J.</au><au>Stewart, Barclay T.</au><au>Yenikomshian, Haig A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical and psychosocial outcomes among burn-injured people with heterotopic ossification: A burn model system study</atitle><jtitle>Burns</jtitle><addtitle>Burns</addtitle><date>2024-05</date><risdate>2024</risdate><volume>50</volume><issue>4</issue><spage>957</spage><epage>965</epage><pages>957-965</pages><issn>0305-4179</issn><issn>1879-1409</issn><eissn>1879-1409</eissn><abstract>Heterotopic ossification (HO), or ectopic bone formation in soft tissue, is a not so rare and poorly understood debilitating sequela of burn injury. Individuals developing HO following burn injuries to their hands often experience reductions in mobility, significant contractures, and joint pain. This study identifies demographic characteristics of individuals who develop HO and compares their physical and psychosocial outcomes to the general burn population.
Participant demographics, injury characteristics, and PROMIS-29 scores across three time points (discharge, six- and 12- months after injury) were extracted from the Burn Model System National Longitudinal Database representing participants from 2015–2022. Mixed-effects linear regression models were used to compare PROMIS scores across all three longitudinal measurements. Models were adjusted for age, sex, race/ethnicity, HO status, and burn size.
Of the 861 participants with data concerning HO, 33 were diagnosed with HO (3.8% of participants). Most participants with HO were male (n = 24, 73%) and had an average age of 40 + /− 13 years. Participants with HO had significantly larger burn size (49 +/−23% Total Body Surface Area (TBSA)) than those without HO (16 +/−17%). Participants with HO reported significantly worse physical function, depression, pain interference and social integration scores than those without HO. After adjusting for covariables, participants with HO continued to report statistically significantly worse physical function than those without HO. Although physical functioning was consistently lower, the two populations did not differ significantly among psychosocial outcome measures.
While HO can result in physical limitations, the translation to psychosocial impairments was not evident. Targeted treatment of HO with the goal of maximizing physical function should be a focus of their rehabilitation.
2b
Symptom Prevalence Study
•Those with heterotopic ossification (HO) had larger burn sizes than those without.•This study highlights physical limitations that burn patients with HO face.•Those with HO do not report worse psychosocial outcomes than those without.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>38267289</pmid><doi>10.1016/j.burns.2024.01.017</doi><tpages>9</tpages></addata></record> |
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| ispartof | Burns, 2024-05, Vol.50 (4), p.957-965 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Burns - complications Burns - psychology Burns outcomes Female Heterotopic ossification Humans Linear Models Longitudinal Studies Male Middle Aged Ossification, Heterotopic - etiology Ossification, Heterotopic - psychology PROMIS-29 Quality of Life Recovery |
| title | Physical and psychosocial outcomes among burn-injured people with heterotopic ossification: A burn model system study |
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