Efficacy of prophylactic antibiotics for the prevention of neutropenic fever in patients with multiple myeloma receiving high-dose cyclophosphamide for stem cell mobilization
High-dose cyclophosphamide (HD-Cy) (3 g/m 2 ) plus granulocyte colony-stimulating factor (G-CSF) is a very effective regimen for peripheral blood stem cell (PBSC) mobilization. Unfortunately, it is associated with an increased risk of neutropenic fever (NF). We analyzed the effect of NF on PBSC aphe...
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| Veröffentlicht in: | Annals of hematology 2024-05, Vol.103 (5), p.1601-1611 |
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| description | High-dose cyclophosphamide (HD-Cy) (3 g/m
2
) plus granulocyte colony-stimulating factor (G-CSF) is a very effective regimen for peripheral blood stem cell (PBSC) mobilization. Unfortunately, it is associated with an increased risk of neutropenic fever (NF). We analyzed the effect of NF on PBSC apheresis results and the efficacy of prophylactic antibiotics for the prevention of NF associated with HD-Cy plus G-CSF for PBSC mobilization in patients with newly diagnosed multiple myeloma (MM). First, patients were divided into NF ( +) and NF ( −) groups according to whether they suffered from NF during mobilization. Second, we divided patients into an antibiotic prophylaxis group and a nonantibiotic prophylaxis group according to whether antibiotic prophylaxis was used during the mobilization period. Our study showed that NF( +) patients (
n
= 44) had lower CD34 + cell dose collection (median 2.60 versus 5.34 × 10
6
/kg,
P
|
| doi_str_mv | 10.1007/s00277-023-05537-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2918510249</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3037663388</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-4df49c41e31b399cfbf50a74e30b87d1572e269af23516b94fc9cf94b9205c403</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS1ERW8LL8ACWWLDJtR_ieMlqkpbqRIbWFuOM75xlcTBdorSh-IZ8e0tILHAG__Md-aMfBB6S8lHSoi8SIQwKSvCeEXqmsuKv0A7Kjgr11a8RDuiuKrqsk7RWUr3hFDWCvYKnfKWNbJu6A79vHLOW2M3HBxeYliGbTQ2e4vNnH3nQzkm7ELEeYACwAOU9zAf8BnWXBQwF9qVQsR-xovJviAJ__B5wNM6Zr-MgKcNxjAZHMGCf_DzHg9-P1R9SIDtZsdiHNIymMn38GSXMkzYwjjiKXR-9I_mYPsanTgzJnjzvJ-jb5-vvl7eVHdfrm8vP91VlkuSK9E7oaygwGnHlbKuczUxUgAnXSt7WksGrFHGMV7TplPC2QIp0SlGaisIP0cfjn3Ll3xfIWU9-XSYxswQ1qSZom1NCROqoO__Qe_DGucyneaEy6bhvG0LxY6UjSGlCE4v0U8mbpoSfUhTH9PUJU39lKbmRfTuufXaTdD_kfyOrwD8CKRSmvcQ_3r_p-0vKTivAg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3037663388</pqid></control><display><type>article</type><title>Efficacy of prophylactic antibiotics for the prevention of neutropenic fever in patients with multiple myeloma receiving high-dose cyclophosphamide for stem cell mobilization</title><source>Springer Nature - Complete Springer Journals</source><creator>Hou, Li-qiong ; Liu, Jun-Ru ; Gu, Jing-Li ; Chen, Mei-Lan ; Kuang, Li-Fen ; Huang, Bei-Hui ; Zou, Wai-yi ; Li, Juan</creator><creatorcontrib>Hou, Li-qiong ; Liu, Jun-Ru ; Gu, Jing-Li ; Chen, Mei-Lan ; Kuang, Li-Fen ; Huang, Bei-Hui ; Zou, Wai-yi ; Li, Juan</creatorcontrib><description>High-dose cyclophosphamide (HD-Cy) (3 g/m
2
) plus granulocyte colony-stimulating factor (G-CSF) is a very effective regimen for peripheral blood stem cell (PBSC) mobilization. Unfortunately, it is associated with an increased risk of neutropenic fever (NF). We analyzed the effect of NF on PBSC apheresis results and the efficacy of prophylactic antibiotics for the prevention of NF associated with HD-Cy plus G-CSF for PBSC mobilization in patients with newly diagnosed multiple myeloma (MM). First, patients were divided into NF ( +) and NF ( −) groups according to whether they suffered from NF during mobilization. Second, we divided patients into an antibiotic prophylaxis group and a nonantibiotic prophylaxis group according to whether antibiotic prophylaxis was used during the mobilization period. Our study showed that NF( +) patients (
n
= 44) had lower CD34 + cell dose collection (median 2.60 versus 5.34 × 10
6
/kg,
P
< 0.001) and slower neutrophil engraftment and platelet engraftment (median 11 versus 10 days,
P
= 0.002, and median 13 versus 11 days,
P
= 0.043, respectively) than NF( −) patients (
n
= 234). Of note, the nonantibiotic prophylaxis group patients (
n
= 30) had a 26.7% incidence of NF. In the patients receiving antibiotic prophylaxis (
n
= 227), the incidence was reduced to 9.3% (
P
= 0.01). The antibiotic prophylaxis patients had higher CD34 + cell collection (median 5.41 versus 2.27 × 10
6
/kg,
P
< 0.001) and lower hospitalization cost of mobilization ($ median 3108.02 versus 3702.39,
p
= 0.012). Thus, our results demonstrate that NF is associated with lower CD34 + cell collection and that antibiotic prophylaxis can reduce the incidence of NF and improve stem cell mobilization and collection outcomes, which reduces the hospitalization cost of mobilization.</description><identifier>ISSN: 0939-5555</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-023-05537-3</identifier><identifier>PMID: 38267561</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antibiotics ; Disease prevention ; Hematology ; Medicine ; Medicine & Public Health ; Multiple myeloma ; Neutropenia ; Oncology ; Original Article ; Stem cells</subject><ispartof>Annals of hematology, 2024-05, Vol.103 (5), p.1601-1611</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c370t-4df49c41e31b399cfbf50a74e30b87d1572e269af23516b94fc9cf94b9205c403</cites><orcidid>0000-0002-0909-4731</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00277-023-05537-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00277-023-05537-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38267561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, Li-qiong</creatorcontrib><creatorcontrib>Liu, Jun-Ru</creatorcontrib><creatorcontrib>Gu, Jing-Li</creatorcontrib><creatorcontrib>Chen, Mei-Lan</creatorcontrib><creatorcontrib>Kuang, Li-Fen</creatorcontrib><creatorcontrib>Huang, Bei-Hui</creatorcontrib><creatorcontrib>Zou, Wai-yi</creatorcontrib><creatorcontrib>Li, Juan</creatorcontrib><title>Efficacy of prophylactic antibiotics for the prevention of neutropenic fever in patients with multiple myeloma receiving high-dose cyclophosphamide for stem cell mobilization</title><title>Annals of hematology</title><addtitle>Ann Hematol</addtitle><addtitle>Ann Hematol</addtitle><description>High-dose cyclophosphamide (HD-Cy) (3 g/m
2
) plus granulocyte colony-stimulating factor (G-CSF) is a very effective regimen for peripheral blood stem cell (PBSC) mobilization. Unfortunately, it is associated with an increased risk of neutropenic fever (NF). We analyzed the effect of NF on PBSC apheresis results and the efficacy of prophylactic antibiotics for the prevention of NF associated with HD-Cy plus G-CSF for PBSC mobilization in patients with newly diagnosed multiple myeloma (MM). First, patients were divided into NF ( +) and NF ( −) groups according to whether they suffered from NF during mobilization. Second, we divided patients into an antibiotic prophylaxis group and a nonantibiotic prophylaxis group according to whether antibiotic prophylaxis was used during the mobilization period. Our study showed that NF( +) patients (
n
= 44) had lower CD34 + cell dose collection (median 2.60 versus 5.34 × 10
6
/kg,
P
< 0.001) and slower neutrophil engraftment and platelet engraftment (median 11 versus 10 days,
P
= 0.002, and median 13 versus 11 days,
P
= 0.043, respectively) than NF( −) patients (
n
= 234). Of note, the nonantibiotic prophylaxis group patients (
n
= 30) had a 26.7% incidence of NF. In the patients receiving antibiotic prophylaxis (
n
= 227), the incidence was reduced to 9.3% (
P
= 0.01). The antibiotic prophylaxis patients had higher CD34 + cell collection (median 5.41 versus 2.27 × 10
6
/kg,
P
< 0.001) and lower hospitalization cost of mobilization ($ median 3108.02 versus 3702.39,
p
= 0.012). Thus, our results demonstrate that NF is associated with lower CD34 + cell collection and that antibiotic prophylaxis can reduce the incidence of NF and improve stem cell mobilization and collection outcomes, which reduces the hospitalization cost of mobilization.</description><subject>Antibiotics</subject><subject>Disease prevention</subject><subject>Hematology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple myeloma</subject><subject>Neutropenia</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Stem cells</subject><issn>0939-5555</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1u1TAQhS1ERW8LL8ACWWLDJtR_ieMlqkpbqRIbWFuOM75xlcTBdorSh-IZ8e0tILHAG__Md-aMfBB6S8lHSoi8SIQwKSvCeEXqmsuKv0A7Kjgr11a8RDuiuKrqsk7RWUr3hFDWCvYKnfKWNbJu6A79vHLOW2M3HBxeYliGbTQ2e4vNnH3nQzkm7ELEeYACwAOU9zAf8BnWXBQwF9qVQsR-xovJviAJ__B5wNM6Zr-MgKcNxjAZHMGCf_DzHg9-P1R9SIDtZsdiHNIymMn38GSXMkzYwjjiKXR-9I_mYPsanTgzJnjzvJ-jb5-vvl7eVHdfrm8vP91VlkuSK9E7oaygwGnHlbKuczUxUgAnXSt7WksGrFHGMV7TplPC2QIp0SlGaisIP0cfjn3Ll3xfIWU9-XSYxswQ1qSZom1NCROqoO__Qe_DGucyneaEy6bhvG0LxY6UjSGlCE4v0U8mbpoSfUhTH9PUJU39lKbmRfTuufXaTdD_kfyOrwD8CKRSmvcQ_3r_p-0vKTivAg</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Hou, Li-qiong</creator><creator>Liu, Jun-Ru</creator><creator>Gu, Jing-Li</creator><creator>Chen, Mei-Lan</creator><creator>Kuang, Li-Fen</creator><creator>Huang, Bei-Hui</creator><creator>Zou, Wai-yi</creator><creator>Li, Juan</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0909-4731</orcidid></search><sort><creationdate>20240501</creationdate><title>Efficacy of prophylactic antibiotics for the prevention of neutropenic fever in patients with multiple myeloma receiving high-dose cyclophosphamide for stem cell mobilization</title><author>Hou, Li-qiong ; Liu, Jun-Ru ; Gu, Jing-Li ; Chen, Mei-Lan ; Kuang, Li-Fen ; Huang, Bei-Hui ; Zou, Wai-yi ; Li, Juan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-4df49c41e31b399cfbf50a74e30b87d1572e269af23516b94fc9cf94b9205c403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antibiotics</topic><topic>Disease prevention</topic><topic>Hematology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple myeloma</topic><topic>Neutropenia</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Stem cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, Li-qiong</creatorcontrib><creatorcontrib>Liu, Jun-Ru</creatorcontrib><creatorcontrib>Gu, Jing-Li</creatorcontrib><creatorcontrib>Chen, Mei-Lan</creatorcontrib><creatorcontrib>Kuang, Li-Fen</creatorcontrib><creatorcontrib>Huang, Bei-Hui</creatorcontrib><creatorcontrib>Zou, Wai-yi</creatorcontrib><creatorcontrib>Li, Juan</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, Li-qiong</au><au>Liu, Jun-Ru</au><au>Gu, Jing-Li</au><au>Chen, Mei-Lan</au><au>Kuang, Li-Fen</au><au>Huang, Bei-Hui</au><au>Zou, Wai-yi</au><au>Li, Juan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of prophylactic antibiotics for the prevention of neutropenic fever in patients with multiple myeloma receiving high-dose cyclophosphamide for stem cell mobilization</atitle><jtitle>Annals of hematology</jtitle><stitle>Ann Hematol</stitle><addtitle>Ann Hematol</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>103</volume><issue>5</issue><spage>1601</spage><epage>1611</epage><pages>1601-1611</pages><issn>0939-5555</issn><eissn>1432-0584</eissn><abstract>High-dose cyclophosphamide (HD-Cy) (3 g/m
2
) plus granulocyte colony-stimulating factor (G-CSF) is a very effective regimen for peripheral blood stem cell (PBSC) mobilization. Unfortunately, it is associated with an increased risk of neutropenic fever (NF). We analyzed the effect of NF on PBSC apheresis results and the efficacy of prophylactic antibiotics for the prevention of NF associated with HD-Cy plus G-CSF for PBSC mobilization in patients with newly diagnosed multiple myeloma (MM). First, patients were divided into NF ( +) and NF ( −) groups according to whether they suffered from NF during mobilization. Second, we divided patients into an antibiotic prophylaxis group and a nonantibiotic prophylaxis group according to whether antibiotic prophylaxis was used during the mobilization period. Our study showed that NF( +) patients (
n
= 44) had lower CD34 + cell dose collection (median 2.60 versus 5.34 × 10
6
/kg,
P
< 0.001) and slower neutrophil engraftment and platelet engraftment (median 11 versus 10 days,
P
= 0.002, and median 13 versus 11 days,
P
= 0.043, respectively) than NF( −) patients (
n
= 234). Of note, the nonantibiotic prophylaxis group patients (
n
= 30) had a 26.7% incidence of NF. In the patients receiving antibiotic prophylaxis (
n
= 227), the incidence was reduced to 9.3% (
P
= 0.01). The antibiotic prophylaxis patients had higher CD34 + cell collection (median 5.41 versus 2.27 × 10
6
/kg,
P
< 0.001) and lower hospitalization cost of mobilization ($ median 3108.02 versus 3702.39,
p
= 0.012). Thus, our results demonstrate that NF is associated with lower CD34 + cell collection and that antibiotic prophylaxis can reduce the incidence of NF and improve stem cell mobilization and collection outcomes, which reduces the hospitalization cost of mobilization.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38267561</pmid><doi>10.1007/s00277-023-05537-3</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0909-4731</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Antibiotics Disease prevention Hematology Medicine Medicine & Public Health Multiple myeloma Neutropenia Oncology Original Article Stem cells |
| title | Efficacy of prophylactic antibiotics for the prevention of neutropenic fever in patients with multiple myeloma receiving high-dose cyclophosphamide for stem cell mobilization |
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