Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging

Accumulation of senescent cells in organs and tissues is a hallmark of aging and known to contribute to age-related diseases. Although aging-associated immune dysfunction, or immunosenescence, is known to contribute to this process, the underlying mechanism remains elusive. Here, we report that type...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2024-03, Vol.57 (3), p.513-527.e6
Hauptverfasser:	Zhou, Zhao, Yao, Jingfei, Wu, Dongmei, Huang, Xun, Wang, Yushuang, Li, Xinmeng, Lu, Qiang, Qiu, Yifu
Format:	Artikel
Sprache:	eng
Schlagworte:	aging DNA repair IL-4 immunosenescence inflammaging macrophage STAT6 type 2 cytokine
Online-Zugang:	Volltext
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