Tumour deposits are independently associated with recurrence in colon cancer
Aim Tumour deposits are focal aggregates of cancer cells in pericolic fat and mesentery, distinct from vessels, nerves and lymphatics. Their presence upstages lymph node negative patients but is ignored in lymph node positive patients. We investigated the clinicopathological factors associated with...
Gespeichert in:
| Veröffentlicht in: | Colorectal disease 2024-03, Vol.26 (3), p.459-465 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 465 |
|---|---|
| container_issue | 3 |
| container_start_page | 459 |
| container_title | Colorectal disease |
| container_volume | 26 |
| creator | Hakki, Lynn Khan, Asama Do, Eric Gonen, Mithat Firat, Canan Vakiani, Efsevia Shia, Jinru Widmar, Maria Wei, Iris H. Smith, J. Joshua Pappou, Emmanouil P. Nash, Garrett M. Paty, Philip B. Garcia‐Aguilar, Julio Weiser, Martin R. |
| description | Aim
Tumour deposits are focal aggregates of cancer cells in pericolic fat and mesentery, distinct from vessels, nerves and lymphatics. Their presence upstages lymph node negative patients but is ignored in lymph node positive patients. We investigated the clinicopathological factors associated with tumour deposits and their impact on recurrence in lymph node positive and negative patients.
Method
Clinicopathological variables were collected from the medical records of patients with Stage I–III colon cancer who underwent resection in 2017–2019. Pathology was reviewed by a gastrointestinal pathologist. Patients with rectal cancer, metastasis, and concurrent malignancy were excluded.
Results
Tumour deposits were noted in 69 (9%) of 770 patients. They were associated with the presence of lymph node metastasis, advanced T category, poorly differentiated tumours, microsatellite stable subtype and lymphovascular and perineural invasion (p |
| doi_str_mv | 10.1111/codi.16873 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2918199204</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2918199204</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3163-e7b52d5414df7cd766729c0aa399f508ecc043f034c11152610e6c8e234b2d2e3</originalsourceid><addsrcrecordid>eNp9kM9LwzAUx4Mobk4v_gFS8CJCZ17SNu1R5q_BYJd5Dln6ihltM5OWsf_ebFUPHszh5T348OG9LyHXQKcQ3oO2pZlClgt-QsaQZDwGDvnpsWdxXgAdkQvvN5RCJiA_JyOes4ynQozJYtU3tndRiVvrTecj5TAybRgxlLar95Hy3mqjOiyjnek-Ioe6dw5bfQAjbWsbqgqjuyRnlao9Xn3_E_L-8ryavcWL5et89riINYewHYp1yso0gaSshC5FlglWaKoUL4oqpTlqTRNeUZ7ocF7KMqCY6RwZT9asZMgn5G7wbp397NF3sjFeY12rFm3vJSsgh6JgwTIht3_QTTi3DdtJTiGljIOggbofKO2s9w4ruXWmUW4vgcpDxvKQsTxmHOCbb2W_brD8RX9CDQAMwM7UuP9HJWfLp_kg_QLnOIXC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3015023170</pqid></control><display><type>article</type><title>Tumour deposits are independently associated with recurrence in colon cancer</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Hakki, Lynn ; Khan, Asama ; Do, Eric ; Gonen, Mithat ; Firat, Canan ; Vakiani, Efsevia ; Shia, Jinru ; Widmar, Maria ; Wei, Iris H. ; Smith, J. Joshua ; Pappou, Emmanouil P. ; Nash, Garrett M. ; Paty, Philip B. ; Garcia‐Aguilar, Julio ; Weiser, Martin R.</creator><creatorcontrib>Hakki, Lynn ; Khan, Asama ; Do, Eric ; Gonen, Mithat ; Firat, Canan ; Vakiani, Efsevia ; Shia, Jinru ; Widmar, Maria ; Wei, Iris H. ; Smith, J. Joshua ; Pappou, Emmanouil P. ; Nash, Garrett M. ; Paty, Philip B. ; Garcia‐Aguilar, Julio ; Weiser, Martin R.</creatorcontrib><description>Aim
Tumour deposits are focal aggregates of cancer cells in pericolic fat and mesentery, distinct from vessels, nerves and lymphatics. Their presence upstages lymph node negative patients but is ignored in lymph node positive patients. We investigated the clinicopathological factors associated with tumour deposits and their impact on recurrence in lymph node positive and negative patients.
Method
Clinicopathological variables were collected from the medical records of patients with Stage I–III colon cancer who underwent resection in 2017–2019. Pathology was reviewed by a gastrointestinal pathologist. Patients with rectal cancer, metastasis, and concurrent malignancy were excluded.
Results
Tumour deposits were noted in 69 (9%) of 770 patients. They were associated with the presence of lymph node metastasis, advanced T category, poorly differentiated tumours, microsatellite stable subtype and lymphovascular and perineural invasion (p < 0.05). The presence of tumour deposits (hazard ratio 2.48, 95% CI 1.49–4.10) and of lymph node metastasis (hazard ratio 3.04, 95% CI 1.72–5.37) were independently associated with decreased time to recurrence. There was a weak correlation (0.27) between the number of tumour deposits and the number of positive lymph nodes.
Conclusion
Tumour deposits are associated with more advanced disease and high‐risk pathological features. The presence of tumour deposits and lymph node metastasis were found to be independent risk factors for decreased time to recurrence. A patient with both lymph node metastasis and tumour deposits is more than twice as likely to have recurrence compared with a patient with only lymph node metastasis. Tumour deposits independently predict recurrence and should not be ignored in lymph node positive patients.</description><identifier>ISSN: 1462-8910</identifier><identifier>EISSN: 1463-1318</identifier><identifier>DOI: 10.1111/codi.16873</identifier><identifier>PMID: 38263577</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Colon cancer ; Colorectal cancer ; lymph node metastasis ; Lymph nodes ; Lymphatic system ; Malignancy ; Medical records ; Mesentery ; Metastases ; Metastasis ; Nerves ; Pathology ; Patients ; recurrence risk ; Risk factors ; tumor deposits ; Tumors</subject><ispartof>Colorectal disease, 2024-03, Vol.26 (3), p.459-465</ispartof><rights>2024 Association of Coloproctology of Great Britain and Ireland.</rights><rights>Copyright © 2024 The Association of Coloproctology of Great Britain and Ireland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3163-e7b52d5414df7cd766729c0aa399f508ecc043f034c11152610e6c8e234b2d2e3</cites><orcidid>0000-0003-2538-5456 ; 0000-0002-4731-1303 ; 0000-0001-9006-9105</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcodi.16873$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcodi.16873$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38263577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hakki, Lynn</creatorcontrib><creatorcontrib>Khan, Asama</creatorcontrib><creatorcontrib>Do, Eric</creatorcontrib><creatorcontrib>Gonen, Mithat</creatorcontrib><creatorcontrib>Firat, Canan</creatorcontrib><creatorcontrib>Vakiani, Efsevia</creatorcontrib><creatorcontrib>Shia, Jinru</creatorcontrib><creatorcontrib>Widmar, Maria</creatorcontrib><creatorcontrib>Wei, Iris H.</creatorcontrib><creatorcontrib>Smith, J. Joshua</creatorcontrib><creatorcontrib>Pappou, Emmanouil P.</creatorcontrib><creatorcontrib>Nash, Garrett M.</creatorcontrib><creatorcontrib>Paty, Philip B.</creatorcontrib><creatorcontrib>Garcia‐Aguilar, Julio</creatorcontrib><creatorcontrib>Weiser, Martin R.</creatorcontrib><title>Tumour deposits are independently associated with recurrence in colon cancer</title><title>Colorectal disease</title><addtitle>Colorectal Dis</addtitle><description>Aim
Tumour deposits are focal aggregates of cancer cells in pericolic fat and mesentery, distinct from vessels, nerves and lymphatics. Their presence upstages lymph node negative patients but is ignored in lymph node positive patients. We investigated the clinicopathological factors associated with tumour deposits and their impact on recurrence in lymph node positive and negative patients.
Method
Clinicopathological variables were collected from the medical records of patients with Stage I–III colon cancer who underwent resection in 2017–2019. Pathology was reviewed by a gastrointestinal pathologist. Patients with rectal cancer, metastasis, and concurrent malignancy were excluded.
Results
Tumour deposits were noted in 69 (9%) of 770 patients. They were associated with the presence of lymph node metastasis, advanced T category, poorly differentiated tumours, microsatellite stable subtype and lymphovascular and perineural invasion (p < 0.05). The presence of tumour deposits (hazard ratio 2.48, 95% CI 1.49–4.10) and of lymph node metastasis (hazard ratio 3.04, 95% CI 1.72–5.37) were independently associated with decreased time to recurrence. There was a weak correlation (0.27) between the number of tumour deposits and the number of positive lymph nodes.
Conclusion
Tumour deposits are associated with more advanced disease and high‐risk pathological features. The presence of tumour deposits and lymph node metastasis were found to be independent risk factors for decreased time to recurrence. A patient with both lymph node metastasis and tumour deposits is more than twice as likely to have recurrence compared with a patient with only lymph node metastasis. Tumour deposits independently predict recurrence and should not be ignored in lymph node positive patients.</description><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>lymph node metastasis</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Malignancy</subject><subject>Medical records</subject><subject>Mesentery</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Nerves</subject><subject>Pathology</subject><subject>Patients</subject><subject>recurrence risk</subject><subject>Risk factors</subject><subject>tumor deposits</subject><subject>Tumors</subject><issn>1462-8910</issn><issn>1463-1318</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kM9LwzAUx4Mobk4v_gFS8CJCZ17SNu1R5q_BYJd5Dln6ihltM5OWsf_ebFUPHszh5T348OG9LyHXQKcQ3oO2pZlClgt-QsaQZDwGDvnpsWdxXgAdkQvvN5RCJiA_JyOes4ynQozJYtU3tndRiVvrTecj5TAybRgxlLar95Hy3mqjOiyjnek-Ioe6dw5bfQAjbWsbqgqjuyRnlao9Xn3_E_L-8ryavcWL5et89riINYewHYp1yso0gaSshC5FlglWaKoUL4oqpTlqTRNeUZ7ocF7KMqCY6RwZT9asZMgn5G7wbp397NF3sjFeY12rFm3vJSsgh6JgwTIht3_QTTi3DdtJTiGljIOggbofKO2s9w4ruXWmUW4vgcpDxvKQsTxmHOCbb2W_brD8RX9CDQAMwM7UuP9HJWfLp_kg_QLnOIXC</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Hakki, Lynn</creator><creator>Khan, Asama</creator><creator>Do, Eric</creator><creator>Gonen, Mithat</creator><creator>Firat, Canan</creator><creator>Vakiani, Efsevia</creator><creator>Shia, Jinru</creator><creator>Widmar, Maria</creator><creator>Wei, Iris H.</creator><creator>Smith, J. Joshua</creator><creator>Pappou, Emmanouil P.</creator><creator>Nash, Garrett M.</creator><creator>Paty, Philip B.</creator><creator>Garcia‐Aguilar, Julio</creator><creator>Weiser, Martin R.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2538-5456</orcidid><orcidid>https://orcid.org/0000-0002-4731-1303</orcidid><orcidid>https://orcid.org/0000-0001-9006-9105</orcidid></search><sort><creationdate>202403</creationdate><title>Tumour deposits are independently associated with recurrence in colon cancer</title><author>Hakki, Lynn ; Khan, Asama ; Do, Eric ; Gonen, Mithat ; Firat, Canan ; Vakiani, Efsevia ; Shia, Jinru ; Widmar, Maria ; Wei, Iris H. ; Smith, J. Joshua ; Pappou, Emmanouil P. ; Nash, Garrett M. ; Paty, Philip B. ; Garcia‐Aguilar, Julio ; Weiser, Martin R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3163-e7b52d5414df7cd766729c0aa399f508ecc043f034c11152610e6c8e234b2d2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Colon cancer</topic><topic>Colorectal cancer</topic><topic>lymph node metastasis</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>Malignancy</topic><topic>Medical records</topic><topic>Mesentery</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Nerves</topic><topic>Pathology</topic><topic>Patients</topic><topic>recurrence risk</topic><topic>Risk factors</topic><topic>tumor deposits</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hakki, Lynn</creatorcontrib><creatorcontrib>Khan, Asama</creatorcontrib><creatorcontrib>Do, Eric</creatorcontrib><creatorcontrib>Gonen, Mithat</creatorcontrib><creatorcontrib>Firat, Canan</creatorcontrib><creatorcontrib>Vakiani, Efsevia</creatorcontrib><creatorcontrib>Shia, Jinru</creatorcontrib><creatorcontrib>Widmar, Maria</creatorcontrib><creatorcontrib>Wei, Iris H.</creatorcontrib><creatorcontrib>Smith, J. Joshua</creatorcontrib><creatorcontrib>Pappou, Emmanouil P.</creatorcontrib><creatorcontrib>Nash, Garrett M.</creatorcontrib><creatorcontrib>Paty, Philip B.</creatorcontrib><creatorcontrib>Garcia‐Aguilar, Julio</creatorcontrib><creatorcontrib>Weiser, Martin R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hakki, Lynn</au><au>Khan, Asama</au><au>Do, Eric</au><au>Gonen, Mithat</au><au>Firat, Canan</au><au>Vakiani, Efsevia</au><au>Shia, Jinru</au><au>Widmar, Maria</au><au>Wei, Iris H.</au><au>Smith, J. Joshua</au><au>Pappou, Emmanouil P.</au><au>Nash, Garrett M.</au><au>Paty, Philip B.</au><au>Garcia‐Aguilar, Julio</au><au>Weiser, Martin R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumour deposits are independently associated with recurrence in colon cancer</atitle><jtitle>Colorectal disease</jtitle><addtitle>Colorectal Dis</addtitle><date>2024-03</date><risdate>2024</risdate><volume>26</volume><issue>3</issue><spage>459</spage><epage>465</epage><pages>459-465</pages><issn>1462-8910</issn><eissn>1463-1318</eissn><abstract>Aim
Tumour deposits are focal aggregates of cancer cells in pericolic fat and mesentery, distinct from vessels, nerves and lymphatics. Their presence upstages lymph node negative patients but is ignored in lymph node positive patients. We investigated the clinicopathological factors associated with tumour deposits and their impact on recurrence in lymph node positive and negative patients.
Method
Clinicopathological variables were collected from the medical records of patients with Stage I–III colon cancer who underwent resection in 2017–2019. Pathology was reviewed by a gastrointestinal pathologist. Patients with rectal cancer, metastasis, and concurrent malignancy were excluded.
Results
Tumour deposits were noted in 69 (9%) of 770 patients. They were associated with the presence of lymph node metastasis, advanced T category, poorly differentiated tumours, microsatellite stable subtype and lymphovascular and perineural invasion (p < 0.05). The presence of tumour deposits (hazard ratio 2.48, 95% CI 1.49–4.10) and of lymph node metastasis (hazard ratio 3.04, 95% CI 1.72–5.37) were independently associated with decreased time to recurrence. There was a weak correlation (0.27) between the number of tumour deposits and the number of positive lymph nodes.
Conclusion
Tumour deposits are associated with more advanced disease and high‐risk pathological features. The presence of tumour deposits and lymph node metastasis were found to be independent risk factors for decreased time to recurrence. A patient with both lymph node metastasis and tumour deposits is more than twice as likely to have recurrence compared with a patient with only lymph node metastasis. Tumour deposits independently predict recurrence and should not be ignored in lymph node positive patients.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38263577</pmid><doi>10.1111/codi.16873</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2538-5456</orcidid><orcidid>https://orcid.org/0000-0002-4731-1303</orcidid><orcidid>https://orcid.org/0000-0001-9006-9105</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1462-8910 |
| ispartof | Colorectal disease, 2024-03, Vol.26 (3), p.459-465 |
| issn | 1462-8910 1463-1318 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2918199204 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Colon cancer Colorectal cancer lymph node metastasis Lymph nodes Lymphatic system Malignancy Medical records Mesentery Metastases Metastasis Nerves Pathology Patients recurrence risk Risk factors tumor deposits Tumors |
| title | Tumour deposits are independently associated with recurrence in colon cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T18%3A07%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tumour%20deposits%20are%20independently%20associated%20with%20recurrence%20in%20colon%20cancer&rft.jtitle=Colorectal%20disease&rft.au=Hakki,%20Lynn&rft.date=2024-03&rft.volume=26&rft.issue=3&rft.spage=459&rft.epage=465&rft.pages=459-465&rft.issn=1462-8910&rft.eissn=1463-1318&rft_id=info:doi/10.1111/codi.16873&rft_dat=%3Cproquest_cross%3E2918199204%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3015023170&rft_id=info:pmid/38263577&rfr_iscdi=true |