JAK1/JAK2 degraders based on PROTAC for topical treatment of atopic dermatitis

Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease. The Janus kinase (JAK) has been identified as a target in AD, as it regulates specific inflammatory genes and adaptive immune responses. However, the efficacy of topically applied JAK inhibitors in AD is limited due to the uniq...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-02, Vol.171, p.116167-116167, Article 116167
Hauptverfasser:	Wu, Junchao, Li, Lisha, Zhu, Quangang, Zhang, Tingrui, Miao, Fengze, Cui, Zhen, Dong, Guoqiang, Tai, Zongguang, Chen, Zhongjian
Format:	Artikel
Sprache:	eng
Schlagworte:	Atopic dermatitis Degraders Inflammatory cytokines Janus kinase Topical treatment
Online-Zugang:	Volltext
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